Antibacterial Activity of Newly Developed Adhesive Resin Cements against Oral Bacteria.

Abstract

: The antibacterial activity of newly-developed adhesive resin cement and primer on oral bacteria was investigated. Three types of adhesive resin cements and primers, and glass-ionomer cement as a control were used in the experiment. S. mutans ATCC 25175, S. sanguis ATCC 10556, S. mitis ATCC 3339, S.salivarius ATCC 25975, and B. gingivalis ATCC 3327 were used as test strains. Antibacterial activity of the resin cement immediately after mixing, after setting and after immersion in artificial saliva for one week were tested. A pH and fluoride release from resin setting were measured, and elute from settings was also measured by high-performance liquid chromatography.Most resin cements and primers showed antibacterial activity against the Streptococci, but did not show antibacterial activity against the Bacteroides. Primers and resin cement immediately after mixing showed greater antibacterial activity compared to the settings of resin after immersion of artificial saliva. A pH and fluoride release of settings of resin cement were not related to the antibacterial activity. HEMA, Mac-10, MDP and Bis-GMA were identified from settings and primers by high-performance liquid chromatography.The results suggested that the antibacterial activity was produced by the monomer of resin cement and primer.