Antibacterial Activity of Neem Extract and its  Green Synthesized Silver Nanoparticles against  Pseudomonas aeruginosa

Senthilkumar, P.; Rashmitha, S.; Veera, Priscilla; Ignatious, C; C, SaiPriya; Samrot, Antony V.

doi:10.22207/jpam.12.2.60

Cited by 17 publications

(8 citation statements)

References 19 publications

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“…Silver nanoparticles (both synthetic and bioderived) have shown evidence of broad-spectrum biocidal activity toward different strains of several species of microbes. It is a potent antibacterial agent toward Escherichia coli, ,, Staphylococcus aureus, ,,, Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus saprophyticus, Pseudomonas putida, etc. It is also a viable antifungal agent for Aspergillus terreus, Mucor indicus, Humicola insolens, Fusarium dimerum, Trichoderma reesei, etc.…”

Section: Resultsmentioning

confidence: 99%

Biogenic Ag Nanoparticles from Neem Extract: Their Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis (NII 08123)

Ulaeto

Mathew

Pancrecious

et al. 2019

ACS Biomater. Sci. Eng.

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Silver nanocrystals have been successfully fabricated by the bioreduction route using the ethanolic extract of Azadirachta indica (neem) leaves as the reducing and capping agent without solvent interference. The silver nanocrystals were grown in a single-step method, without the influence of external energy or surfactants, and at room temperature. The nanoparticles were prepared from different ratios of silver ions to reducing agent molecules and were characterized by UV–vis spectroscopy and transmission electron microscopy (TEM). The nanoparticles were roughly spherical and polydispersed with diameters of less than 40 nm, as determined with high-resolution transmission electron microscopy (HRTEM). Fast Fourier transform (FFT) analysis and X-ray diffraction (XRD) analysis elucidated the crystalline nature of the nanoparticles. The presence of participating functional groups was determined with Fourier transform infrared (FTIR) spectroscopy. The synthesized silver nanoparticles were analyzed as a potential surface-enhanced Raman spectroscopy (SERS) substrate by incorporating rhodamine B as the Raman reporter molecule. The bioreduction process was monitored through SERS fingerprint, which was evaluated by the change in vibrational energies of metal–ligand bonds. It was possible to detect the SERS spectral pattern of the probe molecules on the Ag nanoparticles without the use of any aggregating agent. Thus, the formation of probable intra- and interparticle hot spots was attributed to evaporation-induced aggregation. Furthermore, stirring and precursor salt concentration influenced the kinetics involved in the fabrication process. The thermal stability of the lyophilized nanoparticles prepared from 0.1 M AgNO3 was evaluated with thermogravimetric analysis (TGA) and had a residual mass of 60% at 600 °C. X-ray photoelectron spectroscopy (XPS) studies were used to validate the compositional and chemical-state information. The biomass-capped silver nanoparticles provided antimicrobial activity by inhibiting the growth of Pseudomonas nitroreducens, a biofilm-forming bacterium, and the fungus, Aspergillus unguis (NII 08123).

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Section: Resultsmentioning

confidence: 99%

Biogenic Ag Nanoparticles from Neem Extract: Their Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis (NII 08123)

Ulaeto

Mathew

Pancrecious

et al. 2019

ACS Biomater. Sci. Eng.

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“…According to Vankar and Shukla ( 2012 ), stable nanoparticles with a multi-shaped morphology and diameters of less than 100 nm of silver are produced when the extract from lemon leaves reduces the concentration of silver ions in the metal. These results show that plant extracts, especially those derived from neem and lemon leaves, are versatile and potent when manufactured in an environmentally responsible manner (Senthilkumar et al 2018 ). However, because of their unique qualities, biologically produced nanoparticles, or NPs, are becoming more and more popular in the pharmaceutical sector.…”

Section: Nanoparticles Approachesmentioning

confidence: 96%

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Fares,

Mahdy,

Ahmed

2024

Planta

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Main conclusion The study thoroughly investigates nanosilver production, properties, and interactions, shedding light on its multifaceted applications. It underscores the importance of characterizing nanosilver for predicting its behavior in complex environments. Particularly, it highlights the agricultural and environmental ramifications of nanosilver uptake by plants. Abstract Nowadays, silver nanoparticles (AgNPs) are a very adaptable nanomaterial with many uses, particularly in antibacterial treatments and agricultural operations. Clarification of key elements of nanosilver, such as its synthesis and characterization procedures, antibacterial activity, and intricate interactions with plants, particularly those pertaining to uptake and translocation mechanisms, is the aim of this in-depth investigation. Nanosilver synthesis is a multifaceted process that includes a range of methodologies, including chemical, biological, and sustainable approaches that are also environmentally benign. This section provides a critical evaluation of these methods, considering their impacts on repeatability, scalability, and environmental impact. The physicochemical properties of nanosilver were determined by means of characterization procedures. This review highlights the significance of analytical approaches such as spectroscopy, microscopy, and other state-of the-art methods for fully characterizing nanosilver particles. Although grasp of these properties is necessary in order to predict the behavior and potential impacts of nanosilver in complex biological and environmental systems. The second half of this article delves into the intricate interactions that plants have with nanosilver, emphasizing the mechanisms of absorption and translocation. There are significant ramifications for agricultural and environmental problems from the uptake of nanosilver by plants and its subsequent passage through their tissues. In summary, by summarizing the state-of-the-art information in this field, this study offers a comprehensive overview of the production, characterization, antibacterial capabilities, and interactions of nanosilver with plants. This paper contributes to the ongoing conversation in nanotechnology. Graphical abstract

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“…Neem oil is good antiseptic for the treatment of skin as furuncles, eczema and intestinal worm infections [ 42 ].The pesticide activity has shown by neem and it is acknowledged for it. Against insects, one of the principal mode of action of neem is metamorphosis disruption and the bitter taste of neem keep the insects away from host plants and make it classic repellent and anti-feedent [ 43 ].A significant blood sugar lowering effects possessed by the alcoholic extract of neem leaves that are very beneficial against diabetes. Many fever-reducing and pain-relieving compounds are produced by neem that can assist in healing of cuts, earaches, burns, headache, sprains as well as fever.…”

Section: Traditional Medicinementioning

confidence: 99%

Known data on the therapeutic use of Azadiracta indica (neem) for type 2 diabetes mellitus

Rekha¹

2022

Bioinformation

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Antibacterial Activity of Neem Extract and its Green Synthesized Silver Nanoparticles against Pseudomonas aeruginosa

Cited by 17 publications

References 19 publications

Biogenic Ag Nanoparticles from Neem Extract: Their Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis (NII 08123)

Biogenic Ag Nanoparticles from Neem Extract: Their Structural Evaluation and Antimicrobial Effects against Pseudomonas nitroreducens and Aspergillus unguis (NII 08123)

Unraveling the mysteries of silver nanoparticles: synthesis, characterization, antimicrobial effects and uptake translocation in plant—a review

Known data on the therapeutic use of Azadiracta indica (neem) for type 2 diabetes mellitus

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