Antibacterial Activity of Medicinal Aqueous Plant Extracts against Mycobacterium tuberculosis

Abstract

Tuberculosis (TB) remains a serious health problem in many regions of the world, and the development of resistance to antibiotics by this microbe created the need for new drugs to replace those which have lost effectiveness. This study assesses the medicinal anti-Mycobacterium tuberculosis properties of natural products obtained from plants collected from Eastern Libya. In this study aqueous extracts of nine different plants were assayed for their Mycobacterium tuberculosis inhibitory activity using the BACTEC MGIT960 susceptibility test method. The aqueous extracts of Ceratonia siliqua L, Helichrysum stoechas (L.) Moench and Thymus algeriensis did not show any activity against M. tuberculosis in different concentrations. The aqueous extract of Marrubium vulgare L. from Syria showed high activity against M. tuberculosis. Marrubium alysson L., Marrubium vulgare L., Pistacia lentiscus L, Quercus coccifera L, Thymus capitatus (L.) Hoffm. & Link, showed varying degrees of activity against M. tuberculosis. The results of this study show that aqueous extracts from six different medicinal plants have different effects against M. tuberculosis in vitro.

Development of Biologically Active Phytosynthesized Silver Nanoparticles Using Marrubium vulgare L. Extracts: Applications and Cytotoxicity Studies

“…Other potential applications of horehound extracts or essential oils are based on their antimicrobial effect. The studies report an antibacterial potential comparable to the standard drug ciprofloxacin [22], effectiveness against several Gram-positive bacterial species (Staphylococcus aureus and S. epidermidis) [23], as well as activity against pathogens like Salmonella enterica, Listeria monocytogene, Pseuodomonas aeruginosa, Helicobacter pylori, Mycobacterium tuberculosis and Agrobacterium tumefaciens [24][25][26].…”