Antibacterial activity of lidocaine in mixtures with Diprivan

Gajraj, R. J.; Hodson, Maureen; Gillespie, J. A.; Kenny, G. N. C.; Scott, N. B.

doi:10.1093/bja/81.3.444

Cited by 30 publications

(22 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The result corresponds to another study¹ which states that Lidocaine has antibacterial effect with bacteriostatic characteristic against test bacteria¹, and is supported by a study conducted by Gajraj et al 2 which suggest that Lidocaine has anti-bacterial power against 2 test bacteria when it is mixed with Diprivan. Lidocaine, however, is less potential compared to Procaine and Prilocaine.…”

Section: Concentrationsupporting

confidence: 72%

Effects of Lidocaine Concentration on Streptococcus Mutans Bacteria

Haryono

Rahajoe

2010

The Indonesian J Dent Res

View full text Add to dashboard Cite

Lidocaine is one of the local anesthetics agents that are frequently used in dentistry. Streptococcus mutan is a gram-positive, facultatively an aerobic bacterium commonly found in human oral cavity. The study aims to find out the effects of Lidocaine concentration against Streptococcus mutans bacteria. The study used experimental design with liquid and solid dilution method to find out bacteriostatic and bacteriocidal effects of Lidocaine concentration. The test bacteria used in the study are the ones, which have been compared with Mcfarland standard solution with 10µCFU/ML concentration. The Lidocaine concentrations were 2%, 1%, 0.5%, 0.25%, 0.125%, 0.0625%, 0.03125%, 0.015625%, and 0.007812%. Kruskal-Wallis and Mann-Whitney methods were used for the statistical test. The result of the study suggests that Lidocaine concentration has effects against Streptococcus mutans bacteria in the concentrations of 2%, 1% and 0.5%, to inhibit bacterial growth (p<0.05), but there was no bacteriocidal potential of Lidocaine concentration against Streptococcus mutans bacteria (p>0.05).

show abstract

Section: Concentrationsupporting

confidence: 72%

Effects of Lidocaine Concentration on Streptococcus Mutans Bacteria

Haryono

Rahajoe

2010

The Indonesian J Dent Res

View full text Add to dashboard Cite

show abstract

“…Since then, interest in the antimicrobial activities of local anaesthetics have spread to clinical disciplines as diverse as dentistry (33), anaesthetics (34)(35)(36)(37)(38)(39)(40)(41)(42), otorhinolaryngology (43), pulmonology (44) and ophthalmology (45,46).…”

Section: Past Investigations Into the Antimicrobial Activity Of Bupivmentioning

confidence: 99%

Microbial growth in a mixture of hyperbaric bupivacaine and fentanyl prepared in a multi-dose syringe in the operating theatre environment

Morgan

2010

Southern African Journal of Anaesthesia and Analgesia

View full text Add to dashboard Cite

“…1,5 The absence of preservatives in the propofol preparation may support microbial growth. [6][7][8][9][10][11][12][13][14] Admixture of thiopentone, 15 lidocaine [16][17][18][19] or disodium edetate 20 diminishes microbial growth in propofol, although microbial destruction is not achieved. Because of this risk, the manufacturer's specific recommendations (Fresenius Kabi Pharmaceutical.…”

Section: [Le Maniement D'usage Du Propofol Prévient La Contamination mentioning

confidence: 99%

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Lorenz

Kolbitsch

Lass‐Flörl

et al. 2002

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : Propofol is a potential vector of infection, because it contains no preservative. Thus, the manufacturer's specific recommendations for preparing injections or infusions go beyond the guidelines commonly used in our operating rooms for preparing other iv drugs. The purpose of the present study was to determine whether in the daily routine of an operating theatre a modified propofol handling technique can prevent contamination as effectively as do the manufacturer's handling recommendations. M Me et th ho od ds s: : A total of 160 consecutive neurosurgical patients were allocated to either Group I (manufacturer's handling recommendations: i.e., 1) disinfecting propofol vials and ampoules before filling syringes; 2) replacing empty syringes; 3) discarding all material at the end of surgery); or Group II (modified propofol handling protocol: i.e., 1) refilling empty syringes; 2) renewing only the infusion line to the patient). R Re es su ul lt ts s: : Total contamination rates were comparable in both groups (Group I: 14/160 (8.75%), Group II: 13/160 (8.13%) (P 2 =0.074; P=0.96). Frequency of contamination was not different between groups; either in sample 1 taken at the beginning of the procedure, (Group I: 5/80 (6.25%) vs Group II: 6/80 (7.5%); P 2 =0.098; P=0.76) or in sample 2, taken at the end, (Group I: 9/80 (11.25%) vs Group II: 7/80 (8.75%); P 2 =0.278; P=0.598). C Co on nc cl lu us si io on n: : We conclude that in the daily routine of the operating theatre following a modified propofol handling protocol prevents contamination of propofol syringes as effectively as does adhering to the manufacturer's specific handling recommendations. However, neither of the tested guidelines completely prevented contamination. Groupe I et 13/160 (8,13 %) dans le Groupe II (P 2 = 0,074; P = 0,96). La fréquence de contamination ne diffère pas d'un groupe à l'autre, pour l'échantillon 1 prélevé au début de l'opération (Groupe I : 5/80 (6,25 %) vs Groupe II : 6/80 (7,5 %); P 2 = 0,098; P = 0,76) ou l'échantillon 2 à la fin (Groupe I : 9/80 (11,25 %)vs Groupe II : 7/80 (8,75 %); P 2 = 0,278; P = 0,598 Objectif : Le propofol, ne contenant aucun agent de conservation, est un vecteur potentiel d'infection. C'est pourquoi les recommandations spécifiques du fabricant au sujet de la préparation d'injections ou de perfusions vont au delà des directives habituellement suivies dans nos salles d'opération pour la préparation d'autres médicaments intraveineux. Nous avons voulu déterminer si, en modifiant le maniement du propofol en salle d'opération, nous pouvions prévenir la contamination aussi efficacement qu'en suivant à la lettre les recom

show abstract

Antibacterial activity of lidocaine in mixtures with Diprivan

Cited by 30 publications

References 36 publications

Effects of Lidocaine Concentration on Streptococcus Mutans Bacteria

Effects of Lidocaine Concentration on Streptococcus Mutans Bacteria

Microbial growth in a mixture of hyperbaric bupivacaine and fentanyl prepared in a multi-dose syringe in the operating theatre environment

Le maniement d’usage du propofol prévient la contamination aussi effectivement que la stricte adhésion aux recommandations du fabricant

Contact Info

Product

Resources

About