Antibacterial activity of lemongrass (Cymbopogon citratus) oil against some selected pathogenic bacterias

Naik, Mohd Irfan; Fomda, Bashir Ahmad; Jaykumar, Ebenezar; Bhat, Javid Ahmad

doi:10.1016/s1995-7645(10)60129-0

Cited by 202 publications

(140 citation statements)

References 14 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…Although a significant number of studies have been used to obtain purified phytochemicals, a very few screening programmes have been initiated on crude plant materials. It has also been widely observed and accepted that the medicinal value of plants lies in the bioactive phytocomponents present in the plants [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] . The results of the present study are encouraging as all the tested extracts revealed antibacterial potential, although the inhibitory activity was strain specific and concentration dependent.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

Khan

Ahmed

Mir

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

Khan

Ahmed

Mir

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Several investigations have shown that the essential oil of C. citratus possesses antibacterial (NAIK et al, 2010), antifungal (NGUEFACK et al, 2012), antioxidant (PEREIRA et al, 2009), anti-Leishmania (MACHADO et al 2012) and insecticidal effects (KUMAR et al, 2013). These properties are attributed primarily to the major constituent of the essential oil, the citral, which is a natural combination of two isomeric aldehydes (Figure 1), neral (cis-citral) and geranial (trans-citral).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus

Macedo

Oliveira

Ribeiro

et al. 2015

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

Parasitic nematodes are of major economic importance in livestock. An alternative for the control of parasites is phytotherapy. This study evaluated the efficacy of Cymbopogon citratus decoction (CcD), C. citratus essential oil (CcEo) and citral against Haemonchus contortus using in vitro egg hatch test (EHT) and larval development test (LDT) and an in vivo test using a Meriones unguiculatus (gerbil) model. The effect of 800 mg/kg CcEo was evaluated in gerbils that had been artificially infected with 5,000 third-stage H. contortus larvae. The effective concentrations required to inhibit 50% (EC50) of egg hatching were 0.46, 0.14 and 0.13 mg/mL for CcD, CcEo and citral, respectively. The EC50 values in the LDT were 5.04, 1.92 and 1.37 mg/mL for CcD, CcEo and citral, respectively. H. contortus population in the group treated with C. citratus essential oil was reduced by 38.5% (P< 0.05) in comparison to the control group. These results suggest that it may be possible to use C. citratus essential oil to control of H. contortus parasite of small ruminant.Keywords: Phytotherapy, anthelmintic, Meriones unguiculatus, in vitro, citral. ResumoO parasitismo por nematoides tem grande importância econômica no rebanho. Uma alternativa para o controle de parasitas é a fitoterapia. Este estudo avaliou a eficácia do decocto de Cymbopogon citratus (DCc), do óleo essencial de C. citratus (OECc) e do citral contra Haemonchus contortus utilizando o teste in vitro de eclosão dos ovos (TEO) e o teste de desenvolvimento larval (TDL) e um teste in vivo com modelo Meriones unguiculatus (gerbil). O efeito de 800 mg/kg de OECc foi avaliado em gerbils infectados artificialmente com 5000 larvas de terceira fase de H. contortus. As concentrações efetivas necessárias para inibir 50% (CE50) da eclosão dos ovos foram 0,46; 0,14 e 0,13 mg/mL para DCc, OECc e citral, respectivamente. Os valores da CE50 no TDL foram de 5,04; 1,92 e 1,37 mg/mL para DCc, OECc e citral, respectivamente. No grupo tratado com óleo de C. citratus a população H. contortus foi reduzida em 38,5% (P < 0,05) em comparação com o grupo controle. Estes resultados sugerem que pode ser possível a utilização de óleo essencial de C. citratus para controle de H. contortus, parasita de pequenos ruminantes.Palavras-chave: Fitoterapia, anti-helmínticos, Meriones unguiculatus, in vitro, citral.

show abstract

“…Stapf (Gramineae), commonly known as lemongrass, is a spontaneous perennial grass native to Sri Lanka and South India and now widely cultivated in other tropical and subtropical countries (Cheel et al, 2005;Figueirinha et al, 2008;Francisco et al, 2011;Shah et al, 2011). Infusions or decoctions derived from the leaves of this plant have been widely used as ethnomedicines for the treatment of inflammation, indigestion, nervous disorder, vascular disease, cancer, as well as other health problems (Francisco et al, 2011;Naika et al, 2010). Volatile compounds and polyphenols are reputed to be the main bioactive ingredients (Figueirinha et al, 2008;Masuda et al, 2008;Naika et al, 2010;Ravinder et al, 2010;Tzortzakis & Economakis, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Infusions or decoctions derived from the leaves of this plant have been widely used as ethnomedicines for the treatment of inflammation, indigestion, nervous disorder, vascular disease, cancer, as well as other health problems (Francisco et al, 2011;Naika et al, 2010). Volatile compounds and polyphenols are reputed to be the main bioactive ingredients (Figueirinha et al, 2008;Masuda et al, 2008;Naika et al, 2010;Ravinder et al, 2010;Tzortzakis & Economakis, 2007).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Bao

Yuan

Wang

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Most of the present studies on the antitumor efficiency of Cymbopogon citratus (DC.) Stapf (Gramineae) are limited to its low-mass compounds, and little information about the antitumor activity of polysaccharides from this plant is available. Objectives: This study focused on the potential antitumor and immunomodulatory activities of polysaccharides (CCPS) from C. citratus. Materials and methods: CCPS was isolated using the water extraction-ethanol precipitation method. The sarcoma 180 (S180) cells-inoculated mice were intraperitoneally administrated with CCPS (30-200 mg/kg/d) for seven consecutive days. The effects of CCPS on tumor growth, thymus and spleen weights, splenocyte proliferation, and cytokine secretion in the tumorbearing mice were measured. The cytotoxicity of CCPS (50-800 lg/mL) towards S180 cells was also studied. Results: CCPS significantly inhibited the growth of the transplanted S180 tumors, with the inhibition rates ranging from 14.8 to 37.8%. Simultaneously, CCPS dose-dependently improved the immunity of the tumor-bearing mice. With the highest dose of 200 mg/kg/d, the thymus and spleen indices were increased by 21.9 and 91.9%, respectively; ConA-and LSP-induced splenocyte proliferations were increased by 32.7 and 35.3%, respectively. The secretions of interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 2 (IL-12), and tumor necrosis factor-a (TNF-a) were increased by 103.2, 40.2, 23.6, and 26.3%, respectively. Nevertheless, almost no toxicity of CCPS towards S180 cells was observed, with the maximal inhibition rate less than 15% at the CCPS concentration of 800 lg/mL. Conclusion: CCPS exhibited antitumor activity in vivo, and this activity might be achieved by immunoenhancement rather than direct cytotoxicity.

show abstract

Antibacterial activity of lemongrass (Cymbopogon citratus) oil against some selected pathogenic bacterias

Cited by 202 publications

References 14 publications

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Contact Info

Product

Resources

About