Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of
Clostridioides difficile
Eugénie Bassères,
Taryn A. Eubank,
Khurshida Begum
et al.
Abstract:Antimicrobial resistance is emerging in clinical strains of
Clostridioides difficile
. Ibezapolstat (IBZ) is a DNA polymerase IIIC inhibitor that has completed phase II clinical trials. IBZ has potent
in vitro
activity against wild-type, susceptible strains but its effect on
C. difficile
strains with reduced susceptibility to metronidazole (MTZ), vancomycin (VAN), or fidaxomicin (FDX) has not been tested. The primary objective … Show more
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