Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients

Aunkor, M. T. H.; Raihan, Topu; Prodhan, Shamsul H.; Metselaar, Hendrik Simon Cornelis; Malik, Syeda Umme Fahmida; Azad, Abul Kalam

doi:10.1098/rsos.200640

Cited by 94 publications

(43 citation statements)

References 83 publications

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“…The silver nanoparticles work by generating vast amounts of silver ions, which influence the permeability of the cell membrane and help to inhibit energy transfer through the transport chain of electrons. In addition, microbial cell damage to DNA [ 336 , 337 , 338 ] has also been identified. Zinc oxide nanoparticles are another type of nanoparticle which grows in the cells and emit Zn +2 ions there.…”

Section: Nanomaterialsmentioning

confidence: 99%

Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics

et al. 2021

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The emergence of infectious diseases promises to be one of the leading mortality factors in the healthcare sector. Although several drugs are available on the market, newly found microorganisms carrying multidrug resistance (MDR) against which existing drugs cannot function effectively, giving rise to escalated antibiotic dosage therapies and the need to develop novel drugs, which require time, money, and manpower. Thus, the exploitation of antimicrobials has led to the production of MDR bacteria, and their prevalence and growth are a major concern. Novel approaches to prevent antimicrobial drug resistance are in practice. Nanotechnology-based innovation provides physicians and patients the opportunity to overcome the crisis of drug resistance. Nanoparticles have promising potential in the healthcare sector. Recently, nanoparticles have been designed to address pathogenic microorganisms. A multitude of processes that can vary with various traits, including size, morphology, electrical charge, and surface coatings, allow researchers to develop novel composite antimicrobial substances for use in different applications performing antimicrobial activities. The antimicrobial activity of inorganic and carbon-based nanoparticles can be applied to various research, medical, and industrial uses in the future and offer a solution to the crisis of antimicrobial resistance to traditional approaches. Metal-based nanoparticles have also been extensively studied for many biomedical applications. In addition to reduced size and selectivity for bacteria, metal-based nanoparticles have proven effective against pathogens listed as a priority, according to the World Health Organization (WHO). Moreover, antimicrobial studies of nanoparticles were carried out not only in vitro but in vivo as well in order to investigate their efficacy. In addition, nanomaterials provide numerous opportunities for infection prevention, diagnosis, treatment, and biofilm control. This study emphasizes the antimicrobial effects of nanoparticles and contrasts nanoparticles’ with antibiotics’ role in the fight against pathogenic microorganisms. Future prospects revolve around developing new strategies and products to prevent, control, and treat microbial infections in humans and other animals, including viral infections seen in the current pandemic scenarios.

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Section: Nanomaterialsmentioning

confidence: 99%

Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics

et al. 2021

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“…The antimicrobial property of graphene‐based materials has been demonstrated in many publications, e.g., it was reported that GO can treat multiple drug‐resistant bacterial superbugs isolated from infected patients, and its efficiency is much higher than some conventional antibiotics, offering hope for a last‐line antibiotic to address the global crisis of antimicrobial resistance. [ 96 ] However, it has also been reported to have no antimicrobial properties in some studies. [ 97 ] In fact, there are a big number of parameters that influence the antimicrobial testing results, which could explain the diverse results reported in the literature.…”

Section: Intrinsic Reactivity Of Go and Its Applications: The Role Ofmentioning

confidence: 99%

Progress in the Understanding and Applications of the Intrinsic Reactivity of Graphene‐Based Materials

Komeily‐Nia

2020

Small Science

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Enhancing the intrinsic reactivity of graphene materials is essential for the development of low‐cost materials such as catalysts for various applications. Although an increasing understanding of the intrinsic reactivity of these materials is being achieved, the mechanisms of these materials for catalyzing various reactions have not been fully understood. It is believed that the intrinsic reactivity of pristine graphene originates from its edge and defect sites, and unpaired electrons (radicals) particularly of graphene oxide have also been demonstrated to contribute to the reactivity. Herein, the various edges and defects, and radicals, as well as their influences on the electron structure, reactivity, and applications of graphene‐based materials are reviewed and analyzed. Knowledge gaps in advancing the understanding of the structure–property–reactivity correlations of these materials are discussed.

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“…The structure of the external coatings of bacteria differs between bacterial species, which has an impact on the cell capacity to tolerate stress such as ROS-related lipid peroxidation and membrane disruption by sharp edges of graphene flakes. In comparison to Gram-negative bacteria, Gram-positive lacking the outer membrane are more sensitive to contact with sharp edges of graphene flakes [ 42 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models

et al. 2021

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There are numerous applications of graphene in biomedicine and they can be classified into several main areas: delivery systems, sensors, tissue engineering and biological agents. The growing biomedical field of applications of graphene and its derivates raises questions regarding their toxicity. We will demonstrate an analysis of the toxicity of two forms of graphene using four various biological models: zebrafish (Danio rerio) embryo, duckweed (Lemna minor), human HS-5 cells and bacteria (Staphylococcus aureus). The toxicity of pristine graphene (PG) and graphene oxide (GO) was tested at concentrations of 5, 10, 20, 50 and 100 µg/mL. Higher toxicity was noted after administration of high doses of PG and GO in all tested biological models. Hydrophilic GO shows greater toxicity to biological models living in the entire volume of the culture medium (zebrafish, duckweed, S. aureus). PG showed the highest toxicity to adherent cells growing on the bottom of the culture plates—human HS-5 cells. The differences in toxicity between the tested graphene materials result from their physicochemical properties and the model used. Dose-dependent toxicity has been demonstrated with both forms of graphene.

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Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients

Cited by 94 publications

References 83 publications

Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics

Nanotechnology as a Novel Approach in Combating Microbes Providing an Alternative to Antibiotics

Progress in the Understanding and Applications of the Intrinsic Reactivity of Graphene‐Based Materials

Comparison of the Toxicity of Pristine Graphene and Graphene Oxide, Using Four Biological Models

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