Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Alcaráz, Lucía Esther; Blanco, Susana; Puig, Olga Nélida; Tomás, F.; Ferretti, F.H.

doi:10.1006/jtbi.2000.2062

Cited by 203 publications

(134 citation statements)

References 17 publications

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“…Statistical analysis [4,32], cluster analysis and principal component (Fig. 3) were performed to determine similarity degree in terms of genotoxic potential for the tested drugs and for the experimental control and their distribution between the two strains.…”

Section: Discussionmentioning

confidence: 99%

“…These compounds are biosynthesized by the plant as a primary defense against their potential enemies, as bacteria, fungi, insects and other predator animals. Consequently they show a variety of biological effects, as anti-inflammatory [1], trypanocidal [2], antibacterial [3,4], and anti-arteriosclerotic properties [5]. In addition, either direct, or indirectly they often integrate the composition of human daily food stuffs [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Genotoxic Potentials of Natural Products Detected by a Short-Term Test Using Diploid Strains of Aspergillus nidulans

Salvador¹,

Zucchi²,

Schinor³

et al. 2008

TOMYCJ

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Main aim is to evaluate the genotoxic potentials of three classes of natural products, a sesquiterpene lactone (cynaropicrin), a saponin (stigmast-7en-3 -ol-glucopyranoside) and a steroid (stigmasterol), at low doses, using the Homozygotization Index test (HI). This short-term test, deals with the determination of alterations in mitotic crossing-over frequencies eventually involving heterozygous auxotrophic genes in diploid strains of Aspergillus nidulans. In this way, treatments of UT448//UT184 and Dp II-I//UT184 diploid strains with the natural products showed that saponin and lactone significantly increased the homozygotization index (HI) of both strains, especially for the diploid Dp II-I//UT184. No effect was observed with the steroid. On this account it presents remarkable potentials to detect the genotoxic/carcinogenic effects of bioactive natural products. Furthermore, this is the first time the low doses effects of bioactive natural products were detected using A. nidulans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genotoxic Potentials of Natural Products Detected by a Short-Term Test Using Diploid Strains of Aspergillus nidulans

Salvador¹,

Zucchi²,

Schinor³

et al. 2008

TOMYCJ

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show abstract

“…The number of phenolic groups may attribute to their relative toxicity to microorganism because of increase in hydroxylation causing greater toxicity [37]. The difference in the antibacterial activity can be attributed to the class of flavonoids (flavones, flavonols, flavan-3-ols, isoflavones, flavanones, and anthocyanidins) and/ or their chemical structure, specifically in regards to the position and number of methoxy and phenolic group within their structure [38][39][40].…”

Section: Total Phenol and Flavonoid Contentmentioning

confidence: 99%

ASSESSMENT OF BIOACTIVE METABOLITES FROM THE ROOT ENDOPHYTE ISOLATED FROM CASUARINA JUNGHUHNIANA Miq.

Bose¹,

Gowrie²

2017

Asian J Pharm Clin Res

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Objective: Casuarina junghuhniana Miq. is a well-known multipurpose tree belonging to family Casuarinaceae. This tree has the ability to sustain in different edaphic and extreme environmental conditions. The root extract of this tree is a rich source of potential secondary metabolites. Therefore, the main objective of this study is to isolate fungal root endophyte from this tree and to determine its bioactive compound which can be utilized in agriculture and pharmaceutical industries.Methods: C. junghuhniana Miq. root samples were collected from the State Forestry Research Institute, Neyveli (Vridhachalam Research Range, Cuddalore District). Isolation of fungal endophyte was carried out using potato dextrose agar medium. The qualitative and quantitative phytochemicals screening and enzyme assays were carried out using standard procedures. Antimicrobial assay was tested against different pathogens using well diffusion method. Further, the phytochemicals in the root extract were evaluated using Fourier transform infrared (FTIR), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) studies.Result: Among the isolated endophytes, the dominant isolate (CJN5) was identified as Aspergillus sp. which showed positive result in the production of industrially important enzymes, namely, cellulase, lipase, and amylase. The qualitative screening revealed the presence of various phytoconstituents. Total phenolic content of culture filtrate extract (CFE) (208.20±2 mg/g) was found higher than culture mycelium extract (CME) (165.5±3 mg/g). The total flavonoid content of CFE (25.95±2 mg/g) was also found higher than CME (3.59±2 mg/g) using respective standards. Antimicrobial activity showed maximum zone of inhibition against Pseudomonas aeruginosa (bacterial pathogen) (24±0.1 mm) and Fusarium oxysporum (fungal phytopathogen) (34±0.2 mm). FTIR analysis showed the presence of varied functional groups. HPLC study revealed the presence of gallic acid and salicylic acid. Several peaks were obtained in GC-MS analysis which indicates the presence of different secondary metabolites. Conclusion:Aspergillus sp, isolated from the root of C. junghuhniana Miq. is a promising source of bioactive compounds which can be utilized in agriculture and pharmaceutical industries.

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“…Flavonoids, synthesized from different substituted aromatic ketones and aromatic aldehyde have a potential value as antimicrobial agents. The antimicrobial activity of flavonoids has been suggested to be related to their chemical structure, especially at the 3-position by different substitutes besides the number and positions of methoxyl and hydroxyl groups [17,18] at ring A and B. Therefore, the structure-activity relationship of flavonoids is an important area of study coherently related with antimicrobial activity [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Flavone Analogues

Kn¹,

Sivakumar²,

Afroze³

2017

J Appl Pharm

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Antibacterial Activity of Flavonoids Against Methicillin-resistant Staphylococcus aureus strains

Cited by 203 publications

References 17 publications

Genotoxic Potentials of Natural Products Detected by a Short-Term Test Using Diploid Strains of Aspergillus nidulans

Genotoxic Potentials of Natural Products Detected by a Short-Term Test Using Diploid Strains of Aspergillus nidulans

ASSESSMENT OF BIOACTIVE METABOLITES FROM THE ROOT ENDOPHYTE ISOLATED FROM CASUARINA JUNGHUHNIANA Miq.

Antimicrobial Activity of Flavone Analogues

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