Antibacterial activity of essential oils from Ethiopian thyme (Thymus serrulatus and Thymus schimperi) against tooth decay bacteria

Damtie, Destaw; Mekonnen, Yalemtsehay

doi:10.1371/journal.pone.0239775

Cited by 18 publications

(11 citation statements)

References 36 publications

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“…Among 79 EsO screened for antibiofilm ability and reducing virulence of the uropathogenic strains of Escherichia coli, thymol‐rich Thymus vulgaris oil and carvacrol‐rich Origanum vulgare oil as well as their major constituents, carvacrol and thymol, inhibited this pathogenic microorganism significantly ( Lee et al, 2017 ). EsO of the Ethiopian Thymus serrulatus and Thymus schimperi containing thymol and carvacrol as the major components demonstrated the significantly high inhibition zones against tooth decay bacteria Streptococcus mutans and Lactobacillus ( Damtie et al, 2020 ). Thymol (55.35%) and p- cymene (11.2%) were the major components of the EsO hydrodistillated from the Turkish Thymus vulgaris .…”

Section: Discussionmentioning

confidence: 99%

Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the Mentheae tribe (Lamiaceae)

Shanaida

Hudz

Białoń

et al. 2021

Saudi Journal of Biological Sciences

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The present study was focused on the chemical composition and antimicrobial activity of the essential oils (EsO) obtained from five Lamiaceae representatives grown in the south of Ukraine. Among them are Salvia sclarea L. , Monarda didyma (cultivar ‘Cambridge Scarlet’), Thymus pulegioides (cultivar ‘2/6-07’) , Thymus vulgaris (cultivar ‘Jalos’) , and Thymus serpyllum L. The component analysis of the EsO was carried out by gas chromatography method coupled with mass spectrometry (GC–MS). The antimicrobial properties of the EsO were determined using the agar diffusion test against widespread pathogenic bacterial strains ( Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Streptococcus pyogenes ) and opportunistic yeast Candida albicans. The EsO of Thymus serpyllum and Thymus vulgaris (cultivar ‘Jalos’) displayed noteworthy antibacterial properties against a wide spectrum of the microorganisms. These antimicrobial properties could be attributed to the high content of aromatic monoterpenoid thymol (52.56% and 47.33%, respectively). The EsO of Salvia sclarea with the dominance of linalyl acetate (45.51%) and linalool (38.98%) as well as Thymus pulegioides (cultivar ‘2/6-07’) containing α- citral (27.10%) and β -citral (17.11%) demonstrated the strongest antimicrobial effects on typical and clinical strains of Staphylococcus aureus with the inhibition zones in the range of 24.0–31.0 mm. The Salvia sclarea EsO demonstrated the most significant effect against clinical strains of Candida albicans . In conclusion, the present study revealed the chemical composition of five Lamiaceae species and cultivars grown in the south of Ukraine and considerable antimicrobial activity of the tested EsO, especially against the typical and clinical strains of Staphylococcus aureus and Candida albicans . The obtained results could be perspective for applying in the pharmaceutical industry and for the conservation of food and cosmetic products.

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Section: Discussionmentioning

confidence: 99%

Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the Mentheae tribe (Lamiaceae)

Shanaida

Hudz

Białoń

et al. 2021

Saudi Journal of Biological Sciences

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“…Studies have shown that essential oils from Thymus schimperi exhibited promising antimicrobial activities. 96 , 97 In silico screening of lead compounds from food promote the therapeutic role of food in combating the COVID-19 pandemic. 98 As the top hits in this study exhibited excellent binding and acceptable ADMET properties, further studies are recommended to optimize these compounds in the plant to design drugs tackling respiratory diseases.…”

Section: Discussionmentioning

confidence: 99%

In silico Screening of Potential SARS-CoV-2 Main Protease Inhibitors from Thymus schimperi

Mengist

Khalid

Adane

2023

AABC

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Background COVID-19 is still instigating significant social and economic chaos worldwide; however, there is no approved antiviral drug yet. Here, we used in silico analysis to screen potential SARS-CoV-2 main protease (M pro ) inhibitors extracted from the essential oil of Thymus schimperi which could contribute to the discovery of potent anti-SARS-CoV-2 phytochemicals. Methods The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of compounds were determined through SwissADME and ProToxII servers. AutoDock tools were used for molecular docking analysis studies, while Chimera, DS studio, and LigPlot were used for post-docking studies. Molecular dynamic simulations were performed for 200 ns under constant pressure. Results All compounds exhibited a bioavailability score of ≥0.55 entailing that at least 55% of the drugs can be absorbed unchanged. Only five (9%), nine (16%) and two (3.6%) of the compounds showed active hepatotoxicity, carcinogenicity, and immunotoxicity, respectively. Except for flourazophore P, which showed a little mutagenicity, all other compounds did not show mutagenic properties. On the other hand, only pinene beta was found to have a little cytotoxicity. Five compounds demonstrated effective binding to the catalytic dyad of the SARS-CoV-2 M pro substrate binding pocket, while two of them (geranylisobutanoate and 3-octane) are found to be the best hits that formed hydrogen bonds with Glu 166 and Ser 144 of SARS-CoV-2 M pro . Conclusion Based on our in silico analysis, top hits from Thymus schimperi may serve as potential anti-SARS-CoV-2 compounds. Further in vitro and in vivo studies are recommended to characterize these compounds for clinical applications.

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“…EOs of Thymus serrulatus and Thymus schimperi were shown to possess strong antibacterial activity against Lactobacillus and S. mutans , with higher contents of thymol and carvacrol compounds reported to be the cause of this inhibition [ 79 ]. Similarly, EOs have been isolated from various parts of Eugenia caryophylata , such as the buds, leaves, and stems, with the main components being eugenol, β-caryophyllene, and eugenyl acetate.…”

Section: Antimicrobial Efficacy Of Eosmentioning

confidence: 99%

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

Basavegowda

Baek

2022

Biomedicines

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Despite the discovery and development of an array of antimicrobial agents, multidrug resistance poses a major threat to public health and progressively increases mortality. Recently, several studies have focused on developing promising solutions to overcome these problems. This has led to the development of effective alternative methods of controlling antibiotic-resistant pathogens. The use of antimicrobial agents in combination can produce synergistic effects if each drug invades a different target or signaling pathway with a different mechanism of action. Therefore, drug combinations can achieve a higher probability and selectivity of therapeutic responses than single drugs. In this systematic review, we discuss the combined effects of different antimicrobial agents, such as plant extracts, essential oils, and nanomaterials. Furthermore, we review their synergistic interactions and antimicrobial activities with the mechanism of action, toxicity, and future directions of different antimicrobial agents in combination. Upon combination at an optimum synergistic ratio, two or more drugs can have a significantly enhanced therapeutic effect at lower concentrations. Hence, using drug combinations could be a new, simple, and effective alternative to solve the problem of antibiotic resistance and reduce susceptibility.

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Antibacterial activity of essential oils from Ethiopian thyme (Thymus serrulatus and Thymus schimperi) against tooth decay bacteria

Cited by 18 publications

References 36 publications

Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the Mentheae tribe (Lamiaceae)

Chromatographic profiles and antimicrobial activity of the essential oils obtained from some species and cultivars of the Mentheae tribe (Lamiaceae)

In silico Screening of Potential SARS-CoV-2 Main Protease Inhibitors from Thymus schimperi

Combination Strategies of Different Antimicrobials: An Efficient and Alternative Tool for Pathogen Inactivation

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