Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with β-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii

Lee, Spencer; Razqan, Ghaida Saleh Al; Kwon, Dong H.

doi:10.1016/j.phymed.2016.11.007

Cited by 68 publications

(41 citation statements)

References 32 publications

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“…Epidemiological studies have indicated that consumption of green tea has potential impact of reducing the risk of many chronic diseases, such as cardiovascular diseases and cancer [78,79]. EGCG possesses various biological effects including anti-obesity and anti-hyperuricemia, anti-oxidative, anti-viral, anti-bacterial, anti-infective, anti-angiogenic, anti-inflammatory and anti-cancer activities [80][81][82][83][84]. It is reported to present anti-cancer effects in variety of cancer cells, including lung, colorectal, prostate, stomach, liver, cervical, breast, leukemia, gastric, bladder cancers [85][86][87][88][89][90].…”

Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Epigallocatechin Gallate (Egcg)mentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…Acinetobacter baumannii is a glucose non‐fermenting, Gram‐negative, nonmotile coccobacillus and a major human pathogen causing hospital‐acquired infections, such as ventilator‐associated pneumonia, bacteraemia, meningitis, and urinary tract and wound infections . This bacterium is also recognized as a cause of community‐acquired pneumonia and wound infections in unusual situations, such as in victims of war or earthquakes …”

Section: Introductionmentioning

confidence: 99%

Star anise (Illicium verum Hook. f.) essential oil: Antioxidant properties and antibacterial activity against Acinetobacter baumannii

Luís

Sousa

Wackerlig

et al. 2019

Flavour & Fragrance J

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The increased resistance of pathogenic bacteria to multiple antimicrobial agents is becoming a significant public health threat. For many pathogenic bacteria there are already limited or no effective antimicrobials available to treat the infections caused by them. Acinetobacter baumannii is a Gram‐negative, biofilm‐forming, nonmotile coccobacillus and a major human pathogen causing hospital‐acquired infections, such as ventilator‐associated pneumonia, bacteraemia, meningitis, and urinary tract and wound infections. There is therefore a clear need to discover new compounds and strategies to overcome widespread antimicrobial resistance, with a focus on A. baumannii strains. Star anise (Illicium verum Hook. f.) has been widely used as an ingredient in traditional Chinese cooking, as a flavouring agent, and as a medicine for over 3000 years; however, the essential oil (EO) isolated from star anise has not been further characterized in terms of its bioactivities and potential applications. In this work, a screening of the biological properties of star anise EO together with its chemical characterization were performed. Special attention was given to the impact of this EO in the formation of biofilms by A. baumannii. It was demonstrated that star anise EO is able to scavenge free radicals, to inhibit lipid peroxidation, and to inhibit protein denaturation, which is associated with its antioxidant and anti‐inflammatory properties. Moreover, the effects of the EO on the planktonic and biofilm cells of A. baumannii, inhibiting the formation of biofilms, dispersing preformed biofilms, and decreasing the capacity of the bacterial cells to adhere to polystyrene, together with its ability to inhibit quorum sensing, were also demonstrated.

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“…EGCG has revealed several beneficial health effects, including anti-inflammatory (Cavet et al 2011), anti-carcinogenic (Farabegoli et al 2011;Santos et al 2013;Radhakrishnan et al 2016;Shin et al 2016), antioxidant (Cavet et al 2011;Zhou and Elias 2013), antiangiogenic (Yamakawa et al 2004;Piyaviriyakul et al 2011), anti-diabetic (Wolfram et al 2006;Chen N et al 2009) and anti-bacterial (Lee S et al 2017). It has also been reported its use as chondroprotective agent as it suppressed the inflammatory response in osteoarthritis models (Akhtar and Haqqi 2011;Min S-Y et al 2015), as well as a cardiovascular protector (Wolfram 2007;Oyama et al 2017) and neuroprotector (Lee JH et al 2015;Ortiz-López et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines

Silva

Martins-Gomes

Fangueiro

et al. 2019

Pharmaceutical Development and Technology

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Several therapeutic properties have been attributed to epigallocatechin gallate (EGCG), a phytopharmaceutical polyphenol with antioxidant and antiproliferative activity.EGCG is however very prone to oxidation in aqueous solutions which changes its bioactive properties. Its loading in nanoparticles has been proposed to reduce its degradation while increasing its in vivo efficacy. The aim of this study was to compare the antiproliferative effect of EGCG before and after its loading in solid lipid nanoparticles (SLNs), against five different cell lines (Caco-2, HepG2, MCF-7, SV-80 and Y-79). EGCG produced concentration-and time-dependent antiproliferative effect, with eficacy dependent on the cell line. The order of potency was: MCF-7>SV-80>HepG2>Y-79>Caco-2, for 24h exposure (MCF-7 IC 50 =58.60±3.29 µg/mL; Caco-2 IC 50 >500.00 µg/mL). To the best of our knowledge this is the first study reporting EGCG antiproliferative effect in SV-80 and Y-79 cells. DDAB-SLN physicochemical properties (size 134nm; PI0.179; ZP +28mV) were only slightly modified with EGCG loading (EGCG-DDAB-SLN: 144nm; PI0.160; ZP +26mV). EGCG loadingin SLN, only slightly increases the EGCG antiproliferative effect in MCF-7 and SV-80 cells. SLN exhibited intrinsic toxicity, attributed to the surfactant used in its production. From the obtained results, the biocompatibility of blank SLN must be also considered when testing the efficacy of loaded phytopharmaceutics.

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Antibacterial activity of epigallocatechin-3-gallate (EGCG) and its synergism with β-lactam antibiotics sensitizing carbapenem-associated multidrug resistant clinical isolates of Acinetobacter baumannii

Cited by 68 publications

References 32 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Star anise (Illicium verum Hook. f.) essential oil: Antioxidant properties and antibacterial activity against Acinetobacter baumannii

Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines

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