Antibacterial activity of efrotomycin.

Frost, Bettina M.; Valiant, Mary E.; Weissberger, Barbara; Dulaney, Eugene L.

doi:10.7164/antibiotics.29.1083

Cited by 26 publications

(10 citation statements)

References 6 publications

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“…Antibacterial Susceptibilities B. bronchiseptica is susceptible to various antimicrobial agents both in vivo and in vitro (6, 55,152). However, there have been problems in providing and maintaining effective concentrations of such agents on infected membrane sur-faces without causing unwanted residues in tissues, particularly in animals used for producing human food.…”

Section: Downloaded Frommentioning

confidence: 99%

Biology of Bordetella bronchiseptica.

Goodnow¹

1980

Microbiological Reviews

278

166

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Section: Downloaded Frommentioning

confidence: 99%

Biology of Bordetella bronchiseptica.

Goodnow¹

1980

Microbiological Reviews

278

166

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“…The finding in laboratory experiments of mutant E. coli and B. subtilis strains resistant to elfamycin antibiotics has been described previously (196,216). Efrotomycin is rapidly absorbed orally (93). It had no influence on S. enterica serotype Typhimurium prevalence, shedding, and resistance profile in swine (118).…”

Section: Other Growth-promoting Antibacterialsmentioning

confidence: 99%

Antimicrobial Growth Promoters Used in Animal Feed: Effects of Less Well Known Antibiotics on Gram-Positive Bacteria

2003

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There are not many data available on antibiotics used solely in animals and almost exclusively for growth promotion. These products include bambermycin, avilamycin, efrotomycin, and the ionophore antibiotics (monensin, salinomycin, narasin, and lasalocid). Information is also scarce for bacitracin used only marginally in human and veterinary medicine and for streptogramin antibiotics. The mechanisms of action of and resistance mechanisms against these antibiotics are described. Special emphasis is given to the prevalence of resistance among gram-positive bacteria isolated from animals and humans. Since no susceptibility breakpoints are available for most of the antibiotics discussed, an alternative approach to the interpretation of MICs is presented. Also, some pharmacokinetic data and information on the influence of these products on the intestinal flora are presented

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“…In addition to great chemical similarity, these antibiotics are all primarily active against a limited number of Gram-positive bacteria, notably bacilli (3,7,16,17), the narrow antibacterial spectrum being ascribed to inefficient uptakes.…”

Section: Introductionmentioning

confidence: 99%

The chemistry of aurodox and related antibiotics

Maehr¹,

Leach²,

Williams³

et al. 1980

Can. J. Chem.

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The studies which led to the complete structure elucidation of the antibiotic aurodox, including the chiralities of all eleven asymmetric centers and the cis–trans isomerism of all seven exocyclic double bonds, are summarized. Aurodox was correlated stereochemically with mocimycin. Thus, aurodox can be described as N-[7-[5(R)-[7-[1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl]-6-methyl-7-oxo-1(E),3(E),5(E)-heptatrienyl]tetrahydro-3(S),4(R)-dihydroxyfuran-2(S)-yl]-6(S)-methoxy-5,7(R)-dimethyl-2(E),4(E)-heptadienyl]-α(S)-ethyl-5,5-dimethyltetrahydro-2(R),3(R),4(R)-trihydroxy-6(S)-[1(E),3(Z)-pentadienyl]-2H-pyran-2-acetamide. Mocimycin, probably identical with kirromycin, is the corresponding N-desmethyl homolog.

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Antibacterial activity of efrotomycin.

Cited by 26 publications

References 6 publications

Biology of Bordetella bronchiseptica.

Biology of Bordetella bronchiseptica.

Antimicrobial Growth Promoters Used in Animal Feed: Effects of Less Well Known Antibiotics on Gram-Positive Bacteria

The chemistry of aurodox and related antibiotics

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