Antibacterial Activity of Dental Composite with Ciprofloxacin Loaded Silver Nanoparticles

Abstract

Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, and ultraviolet-visible (UV-vis) spectroscopy. CIP-AgNPs were added to resin composites and the antibacterial activity of the dental composite discs were realized against Enterococcus faecalis, Streptococcus mutans, and the Saliva microcosm. The biocompatibility of modified resin composites was assessed and mechanical testing of modified dental composites was also performed. The results indicated that the antibacterial activity and compressive strength of resin composites containing CIP-AgNPs were enhanced compared to the control group. They were also biocompatible when compared to resin composites containing AgNPs. In short, these results established strong ground application for CIP-AgNP-modified dental composite resins.

Effectiveness of Se/ZnO NPs in Enhancing the Antibacterial Activity of Resin-Based Dental Composites

“…Enhanced antibacterial activity was also observed in a previous study in which Ag was doped on ZnO and incorporated into resin composites [ 7 , 41 ]. The greater the concentration of NPs in composite resin, the greater the enhancement in the antibacterial activity observed, which was similar to a previous study [ 7 , 15 ]. When tested for cytotoxicity, less cytotoxicity was observed even at higher concentrations of Se/ZnO NPs.…”

“…The synthesized pristine and Se/ZnO NPs were confirmed by several characterization techniques routinely used [ 15 , 25 , 26 , 27 , 28 ]. The first confirmation was done by UV-Vis spectrophotometry from UV-2800 BMS Biotechnology Medical Services, Madrid, Spain, spectrophotometer.…”

“…One strategy was to incorporate antibiotics in dental restorative materials to reduce the adherence of biofilm-forming pathogens on the surface of dental materials [ 14 ]. These antibiotics limit biofilm accumulation, hence controlling the acid-enforced demineralization, which eventually prolongs the composite resin’s life [ 15 , 16 ] and limits the occurrence of secondary caries.…”

Silymarin Encapsulated Liposomal Formulation: An Effective Treatment Modality against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats

“…Nanoparticle size was measured to be 24 nm for unloaded liposomes and 67 nm for silymarin-loaded liposomes. The size increase confirmed the drug loading [ 36 , 39 ]. However, zeta potential measurements showed values of −14.8 mV and −17.8 mV.…”

“…It was revealed that the SLNPs exhibited spherical morphology and had an average size of 67 nm, as seen in Figure 3 , whereas the BLNPs had an average size of 24 nm. This demonstrated successful loading of silymarin in the liposome [ 36 ].…”