Antibacterial activity of constituents from Salvia buchananii Hedge (Lamiaceae)

Bisio, Angela; Schito, Anna Maria; Parricchi, Anita; Mele, Giacomo; Romussi, Giovanni; Malafronte, Nicola; Oliva, Patrizia; Tommasi, Nunziatina De

doi:10.1016/j.phytol.2015.10.005

Cited by 13 publications

(19 citation statements)

References 38 publications

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“…After carefully undertaken biological assays, the MIC values for this natural diterpene were very low to most microorganisms and could be stated as very promising, as they were lower than 10.0 µg mL -1 . 36,39 These values are also lower than some previously reported in the literature for other diterpenes, such as clerodanes, 40 isopimaranes 41 and abietanes. 42 With these results, we can state that Urzúa's hypothesis is confirmed so far.…”

Section: Forcontrasting

confidence: 59%

Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria

Soares

Matos

Silva

et al. 2018

J. Braz. Chem. Soc.

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In this work, a search for antimicrobial agents against multi-drug resistant (MDR) bacteria was undertaken. It involved two natural diterpenes of different basic skeletons, named ent-kaurenoic acid and ent-pimaradienoic acid, that were used as precursors to access 28 semi-synthetic derivatives that were also submitted to biological assays. All 30 substances were assayed against a set of seven clinically isolated MDR bacteria, including three Staphylococcus aureus strains. Results classified both natural compounds as promising bactericidal antimicrobial agents against these MDR bacteria, especially for their performance in time-kill curve assay, improving on the positive control vancomycin. Moreover, di-hydro ent-pimaradienoic acid, obtained as one of the derivatives, also displayed promising minimum inhibitory concentration (MIC) values against the microorganism set, proving optimum activity against S. aureus strains. Thereby, this work also yielded a promising semi-synthetic bacteriostatic antimicrobial agent against MDR S. aureus. Furthermore, the study was carried out with 30 structures in order to verify the veracity and scope of Urzúa's hypothesis about the structure-activity relationship between diterpenes and antimicrobial action. Our results are 93% in agreement with this hypothesis.

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Section: Forcontrasting

confidence: 59%

Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria

Soares

Matos

Silva

et al. 2018

J. Braz. Chem. Soc.

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“… 2 − 4 The lipophilic extracts of plant surfaces were shown to possess antimicrobial activities, 5 − 7 due to the secretion of defense compounds onto the cuticular layer. 8 − 10 In a search for diterpenoids from Salvia species with activity against multidrug-resistant human clinical strains, 11 − 13 the aerial parts of Salvia tingitana Etl. (Lamiaceae) were investigated.…”

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confidence: 99%

Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana

et al. 2020

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A surface extract of the aerial parts of Salvia tingitana afforded a nor-sesterterpenoid ( 1 ) and eight new sesterterpenoids ( 2 –- 9 ), along with five known sesterterpenoids, five labdane and one abietane diterpenoid, one sesquiterpenoid, and four flavonoids. The structures of the new compounds were established by 1D and 2D NMR spectroscopy, HRESIMS, and VCD data and Mosher’s esters analysis. The antimicrobial activity of compounds was evaluated against 30 human pathogens including 27 clinical strains and three isolates of marine origin for their possible implications on human health. The methyl ester of salvileucolide ( 10 ), salvileucolide-6,23-lactone ( 11 ), sclareol ( 15 ), and manool ( 17 ) were the most active against Gram-positive bacteria. The compounds were also tested for the inhibition of ATP production in purified mammalian rod outer segments. Terpenoids 10 , 11 , 15 , and 17 inhibited ATP production, while only 17 inhibited also ATP hydrolysis. Molecular modeling studies confirmed the capacity of 17 to interact with mammalian ATP synthase. A significant reduction of ATP production in the presence of 17 was observed in Enterococcus faecalis and E. faecium isolates.

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“…In this study the activity test of their mixture (ursolic/oleanolic acids) was not possible as a result of insufficient amount isolated. Although, in a few cases the activity of their mixture in other pharmacological activities has shown to be greater than that of the single compounds, 26,27 and extensive data about the synergistic antimalarial activity of these two isomers is lacking. Some studies have recently described ursolic acid as a pentacyclic triterpenoid with a wide spectrum of pharmacological activities such as protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effect on skeletal muscles, antiosteoporosis, antimicrobial effect against numerous strains of bacteria, anti HIV and HCV viruses and antimalarial among others 28,29,30 Consequently, it is plausible to suggest that the presence of ursolic acid in C. zenkeri contribute hugely to the different pharmacological actions [13][14][15][16] exerted by the plant.…”

Section: Resultsmentioning

confidence: 99%

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

Oluyemi¹,

Samuel²,

Kählig³

et al. 2019

actapharm

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Combretum genus (Combretaceae) is used locally in the treatment of various diseases including malaria. Current study aimed to investigate the antiplasmodial activities of methanol extract of C. zenkeri in Plasmodium falciparum chloroquine sensitive (D10) and resistant (W2) strains and identify the bioactive principles. Repeated chromatographic separation was carried out on the chloroform fraction to afford the isolation of bioactive compounds which was characterized by application of spectroscopic techniques (ESI-MS, HR-ESIMS, 1D and 2D NMR). Antiplasmodial activities of chloroform fraction (D10; IC 50 = 12.57±1.57 μg/mL and W2; IC 50 = 12.14±0.95 μg/mL) showed more activity than the n-butanol fraction (D10; IC 50 = 61.98±3.25 μg/mL and W2; IC 50 = 61.26±8.64 μg/mL). Phytochemical investigation of the extract afforded isolation of two triterpenes with antimalarial activities. This paper identified for the first time the antimalarial principles in C. zenkeri as ursolic and oleanolic acids; which justified the local use of the plant in the treatment of malaria.

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Antibacterial activity of constituents from Salvia buchananii Hedge (Lamiaceae)

Cited by 13 publications

References 38 publications

Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria

Antimicrobial Potential of Natural and Semi-Synthetic ent-Kaurane and ent-Pimarane Diterpenes against Clinically Isolated Gram-Positive Multidrug-Resistant Bacteria

Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana

Isolation of two homologous triterpenes with antimalarial activities from the leaf extract of combretum zenkeri

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