Antibacterial Activity of Clove Medicinal Plants (Bischofia javanica Blume) Against Cell Damage of Staphylococcus aureus and Salmonella enterica

Abstract

This study aimed to isolate secondary metabolites and to test the antibacterial activity of cingkam bark extracts. The antibacterial activity test was carried out using the disc diffusion method. Determination of the minimum inhibitory concentration (MIC) in vitro by micro dilution method against pathogenic bacteria, namely Salmonella enterica ATCC 14028 and Staphylococcus aureus ATCC 25923. The results of the research that have been carried out are known to have antibacterial activity against Salmonella enterica and Staphylococcus aureus. The extraction that produced the strongest antibacterial activity was the extraction technique with methanol as a solvent on Salmonella enterica bacteria. In Staphyloccus aureus, the extraction technique with ethyl acetate solvent produces the strongest antibacterial activity. The MIC concentration value produced the same response to the two test bacteria, namely 6.25 mg/mL. Cingkam bark extracts has antibacterial activity against Salmonella enterica and Staphylococcus aureus.