Antibacterial activity of Azadirachta indica, Pongamia pinnata, Psidium guajava and Mangifera indica and their mechanism of action against Streptococcus mutans

Bodiba, Dikonketso; Prasad, P. Rajendra; Srivastava, Amrita; Crampton, Bridget Genevieve; Lall, Namrita

doi:10.1016/j.sajb.2018.02.021

Cited by 3 publications

(7 citation statements)

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“…Phytochemicals isolated from plants that can be used as effective and economical treatments are needed [31]. However, many plant products such as herbs and spices show toxicity to cells, and hence, cytotoxicity tests and dose controls are needed for their safe use [32]. According to the randomized controlled clinical trial of Usha et al (2017), a 0.5% extract of Stevia rebaudiana leaves reduced cariogenic organisms significantly and promoted the buffering capacity of the saliva in patients at high for caries [33].…”

Section: Natural Products Plant Extracts and Probioticsmentioning

confidence: 99%

“…More studies are, however, required to unveil more details about the mechanism of action of anti-caries bioactive compounds. In addition to their antibacterial activity, plants often possess natural antioxidants due to the presence of polyphenols and flavonoids [32]. Natural plants can be an adjunct therapy to mechanical dental biofilm control.…”

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

“…Many plant extracts with complex chemical composition, including alkaloids, avonoids, isoavonoids, tannins, cumarins, glycosides, terpens, phenolic, phenylpropanol, monoterpenaldehyde, and monoterpene alcohol, can be used for caries prevention purposes [92]. Bodiba et al (2018) demonstrated the possible future use of the extract of Pongamia pinnata, Azadirachta indica, Psidium guajava, and Mangifera indica for the prevention of dental caries. These researchers tested the antibacterial activity of the herbs mentioned above against S. mutans using a microdilution method.…”

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

“…These researchers tested the antibacterial activity of the herbs mentioned above against S. mutans using a microdilution method. Using the checkerboard method to measure the synergistic ability of the herbs, they proved the important role of herbs in dentistry [32]. Phytochemicals isolated from certain herbs used in traditional medicine have been proposed as potential alternatives against cariogenic microbes that cause dental caries [90].…”

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

“…Wang et al (2019) demonstrated that the cooperative fermentation of probiotics and a Chinese herbal medicine had a synergistic antifungal effect [83]. A synergistic antibacterial effect was observed by combining Azadirachta indica, Pongamia pinnata, Psidium guajava, and Mangifera indica against S. mutans [32]. In another study, a combination of gingerol and allicin produced a great antimicrobial action [83].…”

Section: Incorporation Of Natural Antimicrobials In Cariesmentioning

confidence: 99%

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Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

et al. 2020

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Dental caries is one of the most common microbe-mediated oral diseases in human beings. At present, the accepted etiology of caries is based on a four-factor theory that includes oral microorganisms, oral environment, host, and time. Excessive exposure to dietary carbohydrates leads to the accumulation of acid-producing and acid-resistant microorganisms in the mouth. Dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Effective preventive methods include inhibiting the cariogenic microorganisms, treatment with an anti-biofilm agent, and sugar intake control. The goal is to reduce the total amount of biofilm or the levels of specific pathogens. Natural products could be recommended for preventing dental caries, since they may possess fewer side effects in comparison with synthetic antimicrobials. Herein, the mechanisms of oral microbial community development and functional specialization are discussed. We highlight the application of widely explored natural products in the last five years for their ability to inhibit cariogenic microorganisms.

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Section: Natural Products Plant Extracts and Probioticsmentioning

confidence: 99%

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

Section: Plant-derived Cariogenic Biofilm Inhibitorsmentioning

confidence: 99%

Section: Incorporation Of Natural Antimicrobials In Cariesmentioning

confidence: 99%

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Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

et al. 2020

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Utilisation of Mangifera indica plant extracts and parts in antimicrobial formulations and as a pharmaceutical excipient: a review

Alaiya

Odeniyi

2023

Futur J Pharm Sci

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Background Antimicrobial resistance and the environmental threat posed by some synthetic antimicrobial agents necessitate more research into development of novel pharmaceutical products that are environmentally friendly. Also, the use of plant derived excipients is growing and opening up new avenue to solve current drug delivery issues in the pharmaceutical industry. Main body This review summarizes studies related to the antimicrobial property of Mangifera indica extracts, possible mechanisms of antimicrobial action and antimicrobial formulations from the plant and overview of researches relating to the use of M. indica as a pharmaceutical excipient. Electronic searches were conducted on databases such as Pub Med, Wiley Online Library (WOL) and Google Scholar with focus on published articles relating to M. indica. Inclusion and exclusion criteria include publications relating to antimicrobial properties of M. indica extracts, its antimicrobial formulations and its use as a pharmaceutical excipient. The electronic searches yielded about 190 articles. From the studies reviewed, the mechanisms of action of phytochemicals described corroborate the antimicrobial activity exhibited by M. indica extracts and its selected formulations. In addition, mango pectin was observed to possess potential as a pharmaceutical excipient. Very few previous review articles based their focus on incorporating mechanism of action of phytochemicals with antimicrobial activity. This review examined antimicrobial properties of M. indica extracts and formulations, major phytochemicals in the plant parts and their possible modes of action. In addition, the study assessed the use of natural polymer derived from mango plant as excipients in pharmaceutical and pharmacological preparations. Conclusion The study concluded that effective antimicrobial activity of mango plant extracts and formulations requires synergy of actions among various phytochemical constituents of the extract or formulation. It is recommended that more researches focused on discovery of new phytochemicals in M. indica, their mechanisms of action and effective utilization of the plant in the pharmaceutical industry should be further explored.

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Recent Progress in CDK4/6 Inhibitors and PROTACs

Wang,

Ba,

Kang

et al. 2023

Molecules

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Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell. Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase (CDK) activation, is a key pathological mechanism in cancer. Recently, selective CDK4/6 inhibitors have shown clinical success, particularly in treating advanced-stage estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. This review provides an in-depth analysis of the action mechanism and recent advancements in CDK4/6 inhibitors, categorizing them based on their structural characteristics and origins. Furthermore, it explores proteolysis targeting chimers (PROTACs) targeting CDK4/6. We hope that this review could be of benefit for further research on CDK4/6 inhibitors and PROTACs.

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Antibacterial activity of Azadirachta indica, Pongamia pinnata, Psidium guajava and Mangifera indica and their mechanism of action against Streptococcus mutans

Cited by 3 publications

References 0 publications

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

Utilisation of Mangifera indica plant extracts and parts in antimicrobial formulations and as a pharmaceutical excipient: a review

Recent Progress in CDK4/6 Inhibitors and PROTACs

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