Antibacterial activity of antileukoprotease

Hiemstra, Pieter S.; Maassen, Robert J.; Stolk, Jan; Heinzel‐Wieland, Regina; Steffens, Gerd; Dijkman, J. H.

doi:10.1128/iai.64.11.4520-4524.1996

Cited by 334 publications

(156 citation statements)

References 38 publications

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“…The significance of these antiproteinases in COPD is not fully understood. It is known that SLPI, apart from inhibiting NE, also inactivates trypsin and chymotrypsin and cathepsin G [196], and it seems likely that the antibacterial activity of SPLI may be of importance for airway defence mechanisms [197]. The more precise role of SLPI in COPD is, however, not known.…”

Section: Antiproteinasesmentioning

confidence: 99%

Aspects on pathophysiological mechanisms in COPD

Larsson

2007

Journal of Internal Medicine

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Chronic obstructive pulmonary disease (COPD) is a condition which is characterized by irreversible airway obstruction due to narrowing of small airways, bronchiolitis, and destruction of the lung parenchyma, emphysema. It is the fourth most common cause of mortality in the world and is expected to be the third most common cause of death by 2020. The main cause of COPD is smoking but other exposures may be of importance. Exposure leads to airway inflammation in which a variety of cells are involved. Besides neutrophil granulocytes, macrophages and lymphocytes, airway epithelial cells are also of particular importance in the inflammatory process and in the development of emphysema. Cell trafficking orchestrated by chemokines and other chamoattractants, the proteinase-antiproteinase system, oxidative stress and airway remodelling are central processes associated with the development of COPD. Recently systemic effects of COPD have attracted attention and the importance of systemic inflammation has been recognized. This seems to have direct therapeutic implications as treatment with inhaled glucocorticosteroids has been shown to influence mortality. The increasing body of knowledge regarding the inflammatory mechanism in COPD will most likely have implications for future therapy and new drugs, specifically aimed at interaction with the inflammatory processes, are currently being developed.

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Section: Antiproteinasesmentioning

confidence: 99%

Aspects on pathophysiological mechanisms in COPD

Larsson

2007

Journal of Internal Medicine

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“…H. pylori status was determined by four methods (histology, 13 C-UBT, RUT®, and serology). Histologic evaluation was performed by standard procedure according to the updated Sydney System [26].…”

Section: Determination Of H Pylori Statusmentioning

confidence: 99%

Helicobacter pylori Infection, but not Low‐Dose Aspirin, Results in a Local Reduction of the Secretory Leukocyte Protease Inhibitor in Gastroduodenal Mucosa

Wex

Treiber

et al. 2006

Helicobacter

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“…The amino acid leucine at position 72 in the C-terminal domain of the mature wild-type hSLPI protein is important for its inhibitory activity, as replacing this amino acid by phenylalanine (in F-hSLPI) or arginine (in R-hSLPI) results in a drastic alteration of the inhibitory activity of SLPI towards serine proteases. 19 Because several of the reported pleiotropic activities of SLPI are not affected when SLPI's protease inhibitory activity is impaired, [8][9][10][11] we wondered whether the malignancy-promoting properties of SLPI are related to its capacity to inhibit proteases. Therefore, plasmids containing mutant F-hSLPI or R-hSLPI cDNA were constructed and transfected into 3LL-S cells.…”

Section: Hslpi's Promalignant Activity Depends On Its Capacity To Inhmentioning

confidence: 99%

Secretory Leukocyte Protease Inhibitor in Cancer Development

Devoogdt

2004

Annals of the New York Academy of Sciences

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Secretory leukocyte protease inhibitor (SLPI), an epithelial-specific serine protease inhibitor of the whey acidic protein (WAP) family, exerts broad tissue-protective functions: on the one hand, it counteracts inflammatory responses and invading pathogens, and on the other hand, it repairs the damaged tissue. Here, we report that subcutaneous in vivo passage of low-malignant 3LL-S cells increases the malignancy of these cancer cells. Applying the subtraction suppressive hybridization method to this cancer model, we identify SLPI as one of the genes whose level of expression directly correlates with the malignancy of the cancer cells. Using transfection experiments, we demonstrate that overexpression of mouse or human SLPI in 3LL-S cells is sufficient to enhance their malignant behavior, and that this activity of SLPI is related to its ability to inhibit serine proteases. Furthermore, using cDNA dot-blot hybridization, we show that in human gynecological cancer tissue SLPI expression is frequently increased as compared with normal tissue. This study underscores the promalignant role of SLPI in the development of cancer and its potential usefulness as a biomarker for gynecological cancer.

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Antibacterial activity of antileukoprotease

Cited by 334 publications

References 38 publications

Aspects on pathophysiological mechanisms in COPD

Aspects on pathophysiological mechanisms in COPD

Helicobacter pylori Infection, but not Low‐Dose Aspirin, Results in a Local Reduction of the Secretory Leukocyte Protease Inhibitor in Gastroduodenal Mucosa

Secretory Leukocyte Protease Inhibitor in Cancer Development

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