Antibacterial activity of Amikacin-immobilized detonation nanodiamond

The possibility of drug delivery and retention in cells due to hydrogen bond formation between enriched nanodiamonds and highly toxic drugs (for example doxorubicin), is investigated by numerical simulation. Using molecular modeling by the density functional theory method with the B3LYP functional and the 6-31G(d) basic set, we analyze hydrogen bond formation and their influence on IR-spectra and structure of molecular complex which is formed due to interaction between doxorubicin and nanodiamonds enriched by carboxylic groups. Numerical modeling of carboxylated nanodiamonds and doxorubicin interaction is based on nanodiamond representation by a diamond-like nanoparticle with simpler structure. Enriched adamantane (1,3,5,7-adamantanetetracarboxylic acid) is used as an example of carboxylated diamond-like nanoparticle. Combined IR spectrum as imposing of IR spectra for doxorubicin and 1,3,5,7-adamantanetetracarboxylic acid various interaction positions is obtained. The combined IR spectrum demonstrates good agreement with experimental data. The obtained results demonstrate that there can be strong hydrogen bonds between doxorubicin and nanodiamond as one of basic mechanism for drug delivery and retention in cells.

Section: Methodsmentioning

confidence: 99%

“…It is nontoxic, biocompatible and able to overcome biological barriers, penetrating into the cells [10]. For the immobilization of drugs on ND surface are commonly used an adsorption [11] and covalent grafting [8,12] …”

Section: Introductionmentioning

confidence: 99%

Possibility of drug delivery due to hydrogen bonds formation in nanodiamonds and doxorubicin: molecular modeling

Bokarev¹,

Пластун²

2018

“…The biomedical aspect of nanodiamond use can also be considered [250][251][252][253][254][255][256][257][258][259][260]. The nanodispersed diamonds (or nanodiamonds) were obtained for the first time in in the USSR in the 1960s [261], but the widespread interest in the research of this material arose in the 1990s due to several factors.…”

Section: Carbon-based Nanostructured Systemsmentioning

confidence: 99%

“…The areas of nanodiamonds application are determined by their inherent outstanding qualities, both characteristic of diamonds in general and specific to nanodiamonds. Such properties as exceptional hardness, the Young's modulus, specific optical properties, biocompatibility, chemical stability, and fluorescence ability make nanodiamonds a promising material for biomedical applications [250][251][252][253][254][255][256][257][258][259][260][261][262][263]. Among the possible areas of biomedical application is the use as a matrix for tissue engineering, creation of implants and, in particular, bioactive substances targeted delivery [250,251,253,255,259].…”

Section: Carbon-based Nanostructured Systemsmentioning

confidence: 99%

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

Остроушко¹,

Gagarin²,

Данилова³

et al. 2019

Nanoscale systems occupy the most important place among the vehicles intended for targeted drug delivery. Such vehicles are considered in this review. Attention is paid to the nanocluster polyoxometalate-based systems which are promising for transdermal iontophoretic transport. In this relation, and due to the characteristics of the skin as a transport medium, the problems of the transfer processes modeling are considered.

“…They are widely studied and used in biophysics and biomedicine; nanoporous materials are applied in drug delivery [1,2], tissue engineering [3], as biosensors [4], have great potential for usage in pharmacology [5], etc.…”

Section: Introductionmentioning

confidence: 99%

Reproduction of the evolution of the liquid front profile in inhomogeneous nanoporous media

Golovina¹,

Chivilikhin²

2017

In recent years possible applications of nanoporous materials in biophysics and biomedicine have become a topic of intense scientific interest. One of the main problems in this field is that of transport processes in inhomogeneous nanoporous media. Another one is the reproduction of the specific evolution of the liquid front profile, observed in one medium, in another medium. In this paper, we present a model which simulates two-dimensional liquid front propagation in inhomogeneous nanoporous media; we also propose a method to evaluate the parameters of the nanoporous medium required for reproduction of the given liquid front propagation.