Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase

Watkins, Sydney M.; Ghose, Debarati; Blain, Joy M.; Grote, Dakota L.; Luan, Chi‐Hao; Clare, Michael; Meganathan, R.; Horn, James R.; Hagen, Timothy J.

doi:10.1016/j.bmcl.2019.126660

Cited by 2 publications

(1 citation statement)

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“…From L. patulum, seven of the ten unique metabolites exhibited intriguing biological properties. Specifically, 2-amino-4-hydroxypyrimidine-5carboxylic acid is known for its antibacterial effects [24], while bruceine D demonstrated antitumor properties [25], and terbutaline was reported for its anti-inflammatory, antiarthritic effects, as well as bronchodilator properties [26,27]. Additionally, cyclopamine, eurycomalactone, and quinaldic acid were found to possess antiviral properties [28][29][30].…”

Section: Metabolic Profilingmentioning

confidence: 99%

Metabolic Profiling, Antiviral Activity and the Microbiome of Some Mauritian Soft Corals

Jahajeeah,

Ranghoo-Sanmukhiya,

Schäfer

2023

Marine Drugs

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Soft corals, recognized as sessile marine invertebrates, rely mainly on chemical, rather than physical defense, by secreting intricate secondary metabolites with plausible pharmaceutical implication. Their ecological niche encompasses a diverse community of symbiotic microorganisms which potentially contribute to the biosynthesis of these bioactive metabolites. The emergence of new viruses and heightened viral resistance underscores the urgency to explore novel pharmacological reservoirs. Thus, marine organisms, notably soft corals and their symbionts, have drawn substantial attention. In this study, the chemical composition of four Mauritian soft corals: Sinularia polydactya, Cespitularia simplex, Lobophytum patulum, and Lobophytum crassum was investigated using LC–MS techniques. Concurrently, Illumina 16S metagenomic sequencing was used to identify the associated bacterial communities in the named soft corals. The presence of unique biologically important compounds and vast microbial communities found therein was further followed up to assess their antiviral effects against SARS-CoV-2 and HPV pseudovirus infection. Strikingly, among the studied soft corals, L. patulum displayed an expansive repertoire of unique metabolites alongside a heightened bacterial consort. Moreover, L. patulum extracts exerted some promising antiviral activity against SARS-CoV-2 and HPV pseudovirus infection, and our findings suggest that L. patulum may have the potential to serve as a therapeutic agent in the prevention of infectious diseases, thereby warranting further investigation.

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