Antibacterial activity and osseointegration of silver-coated poly(ether ether ketone) prepared using the polydopamine-assisted deposition technique

Chang-cheng, Gao; Wang, Yong; Han, Fengxuan; Yuan, Zhangqin; Li, Qiang; Shi, Chen; Cao, Weiwei; Zhou, Pinghui; Xing, Xiaodong; Li, Bin

doi:10.1039/c7tb02436c

Cited by 59 publications

(45 citation statements)

References 68 publications

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“…Recently, multiple PEEK modification studies have been conducted to improve the osseointegration between implants and bone tissue [ [10] , [11] , [12] ]. Three main strategies has been studied to overcome the bio-inert character of PEEK, including surface modification with either physical or chemical methods, preparation of functional PEEK composites by blending bioactive materials and designing three dimensional porous PEEK materials [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Wan

Zhang

Guo

et al. 2020

Bioactive Materials

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Fabricating a desired porous structure on the surface of biomedical polyetheretherketone (PEEK) implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness. In this study, a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide (SO 3 ) for different time (5, 15, 30, 60 and 90 min). Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical properties. The protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of sulfonation. In combination of the appropriate micromorphology and bioactive sulfonate components, the cell adhesion, migration, proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 min. Finding from this study revealed that controllable sulfonation by gaseous SO 3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

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Section: Introductionmentioning

confidence: 99%

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Wan

Zhang

Guo

et al. 2020

Bioactive Materials

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“…Being able to award the biosubstitutes multiple functions to meet the requirements of tissue regeneration, surface modification of orthopaedic implants has evolved into an essential and promising technology. For example, the osseointegration and antimicrobial properties of orthopaedic implants can be significantly improved on appropriate surface modification [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-assisted surface modification for orthopaedic implants

Jia

Han

Wang

et al. 2019

Journal of Orthopaedic Translation

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110

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Along with the massive use of implants in orthopaedic surgeries in recent few decades, there has been a tremendous demand for the surface modification of the implants to avoid surgery failure and improve their function. Polydopamine (PDA), being able to adhere to almost all kinds of substrates and possessing copious functional groups for covalently immobilizing biomolecules and anchoring metal ions, has been widely used for surface modification of materials since its discovery in the last decade. PDA and its derivatives can be used for the surface modification of orthopaedic implants to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation, and may thereby enhance the function of existing implants. In addition, the osseointegration and antimicrobial properties of orthopaedic implants may also be improved by PDA-based coatings. The aim of this review is to provide a brief overview of current advances of surface modification technologies for orthopaedic implants using PDA and its derivatives as a medium. Given the versatility of PDA-based adhesion, such PDA-assisted surface modification technologies will certainly benefit the development of new orthopaedic implants. The translational potential of this article Surface treatments of orthopaedic implants, which are normally inert materials, are essential for their performance in vivo. This review summarizes recent advances in the surface modification of orthopaedic implants using facile and highly versatile techniques based on the use of polydopamine (PDA) and its derivatives.

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“…26,27 In a similar manner to prophylactic antibiotic use, Gao et al demonstrated that the majority of silver from 70 nm AgNP on the surface of a PEEK implant were released within 24 hours, yielding a 5 lg/mL extract; the cumulative silver release curve plateaued after 5 days. 28 A reduction in viability of MC3T3-E1 osteoblast precursor cells was observed, but this difference versus the control was eliminated by day 5 due to dilution of the silver with repeated media changes. Implantation of this material into rats demonstrated antimicrobial activity and was observed to osseointegrate similar to the materials without AgNP after 2 weeks of implantation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Subcytotoxic Exposure of Silver Nanoparticles on Osteogenic Differentiation of Human Bone Marrow Stem Cells

NguyenAlexander

PatelReema

NobleJade

et al. 2019

Applied In Vitro Toxicology

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Introduction: In vitro toxicology evaluations utilizing human stem cell models represent attractive alternatives to conventional animal models, which are not always predictive of human responses. Silver nanoparticles (AgNP) are a potent antimicrobial for use in orthopedic devices. However, AgNP exposure may alter the behavior of stem cells within the bone marrow. The aim of this study was to determine if differences in cell proliferation, early, and late osteogenic differentiation markers can be detected in osteogenically differentiating human bone marrow mesenchymal stem cells (hBMSC) over a 21-day period at AgNP concentrations that are not considered cytotoxic after 24-hour exposure per ISO 10993-5 cytotoxicity testing guidelines. Materials and Methods: Polyvinylpyrrolidone (PVP)-coated 10 nm AgNP were evaluated for their short-term (24-hour) cytotoxicity to hBMSC using the MTT assay to determine subcytotoxic concentrations for the subsequent long-term study investigating osteogenic differentiation. hBMSC were exposed to 1, 5, or 10 lg/mL AgNP in three different exposure scenarios: single (24-hour), repeated (24-hour at 1, 7, and 14 days), or continuous (21day) exposure. Alkaline phosphatase (early osteogenic differentiation marker), hydroxyapatite deposition (late marker), and cell proliferation were measured at days 1, 7, 14, and 21. Results: AgNP exposure reduced cell proliferation for all treatments. Neither differentiation marker expression was observed at any timepoint in hBMSC exposed to AgNP at 10 lg/mL for any exposure scenario or in cells exposed to 5 lg/mL in the repeated or continuous exposure scenarios. Conclusions: Differences in proliferation and osteogenic marker expression were detected in the different exposure scenarios at AgNP concentrations identified as subcytotoxic in a 24-hour exposure assay.

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Antibacterial activity and osseointegration of silver-coated poly(ether ether ketone) prepared using the polydopamine-assisted deposition technique

Abstract: PEEK-PDA-Ag substrates may be a promising orthopaedic implant material due to the outstanding biocompatibility and antibacterial properties.

Cited by 59 publications

References 68 publications

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Polydopamine-assisted surface modification for orthopaedic implants

Effects of Subcytotoxic Exposure of Silver Nanoparticles on Osteogenic Differentiation of Human Bone Marrow Stem Cells

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