Antibacterial activity and cytotoxicity of flavonoids compounds isolated from Pseudarthria hookeri Wight &amp; Arn. (Fabaceae)

Dzoyem, Jean Paul; Tchamgoue, Joseph; Tchouankeu, Jean Claude; Kouam, Siméon F.; Choudhary, M. Iqbal; Bakowsky, Udo

doi:10.1016/j.sajb.2017.11.001

Cited by 45 publications

(18 citation statements)

References 14 publications

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“…According to their MBC values, [15] compound 1 displayed bactericidal effect on S. dysenterie and compounds 2 , 5 and 6 on K. pneumonia . The MBC / MIC ratio of these compounds on the specific micro‐organisms were comparable to that obtained with the reference antibiotic ciprofloxacin, suggesting that further structural modifications may lead to more active antibacterial agents.…”

Section: Resultsmentioning

confidence: 99%

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

et al. 2021

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Three new sesquiterpene alkaloids of the polyveoline type containing eight‐membered lactam rings named greenwaylactam A (1), B (2) and C (3) were isolated from the leaves of a Cameroonian medicinal plant Greenwayodendron oliveri (Engl.) Verdc along with three known compounds diacetylpolyveoline (4), N‐acetyl‐8α‐polyveolinone (5) and methyl pheophorbide‐A (6). These comprise the first members of a new class of ξ‐lactam sesquiterpenes. Compounds were isolated by means of successive column chromatographies and their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS. The configuration of 1 was deduced from its single‐crystal X‐ray diffraction. The crude extract and some isolated compounds were assessed for their antibacterial activity against four enteric bacterial strains Escherichia coli, Salmonelles typhi, Shigella dysenterie and Klebseilla pneumonie using the micro‐dilution method. Compounds 1, 2, 5 and 6 were the most active with MIC values varying between 31.25–250 μg/mL.

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Section: Resultsmentioning

confidence: 99%

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

et al. 2021

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“…Excluding some of them, there are apparently similar pathways of mammalian cytotoxicity. Therefore, comparable doses of in vitro cytotoxicity against mainly mammalian tumor cell lines (Hep-G2, MCF-7, Jurkat T-cell leukemia) have been determined [33,34,35].…”

Section: Discussionmentioning

confidence: 99%

Comparative In Vitro Evaluation of Antibacterial and Osteogenic Activity of Polysaccharide and Flavonoid Fractions Isolated from the leaves of Saussurea controversa

et al. 2019

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The osteogenic, cytotoxic, and antibacterial activities of polysaccharide (PS-SC) and flavonoid (F-SC) fractions isolated from the leaves extract of Saussurea controversa were studied in vitro. F-SC consists of the five quercetin glycosides in the ratio 2:8:10:1:4, which were isolated from the leaves extract of S. controversa and have been characterized previously. PS-SC was first isolated from the leaves extract of S. controversa and has been described. PS-SC consists in 30 compounds is characterized by a high degree of heterogeneity with a heterogeneity index of 19.74. The Mw and Mn of PS-SC were 108.6 and 5.5 kDa, respectively. Structural fragments are represented by galactose, arabinose, xylose, glucose, uronic acids, mannose, and rhamnose in a 10.1:3.3:2.2:2.1:1.7:0.9:0.5 molar ratio. F-SC as compared with PS-SC showed in vitro microbicidal (50 g/L) and better bacteriostatic (6.25 g/L versus 25 g/L of PS-SC) effects against the 24-h growth of Staphylococcus aureus strain 209 P and a 21-day absence of cytotoxicity on human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs). Both fractions (PS-SC > F-SC) at doses of 10–50 mg/L stimulated differentiation of hAMMSCs into secreting osteoblasts accompanied by local mineralization of extracellular matrix. These fractions of S. controversa and especially F-SC, might be promising peroral drugs in the complex treatment of bone fractures and for prophylaxis of their infectious complications.

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“…[ 25 ]. Similarly, Pseudarthria hookeri Wight and Arn which has been used as traditional herbal medicine in Africa [ 26 , 27 ] for the treatment of pneumonia, abdominal pains, cough and diarrhea. According to the antibacterial study of this medicinal species, Dzoyem and his team found that flavonoids from this plant showed the highest antibacterial effect against both gram-positive and gram-negative bacteria e.g., E. coli , Klebsiella pneumonia (Schroeter) Trevisan, Pseudomonas aeruginosa (Schroeter) Migula, Enterococcus faecalis (Andrew and Horder) Schleifer and Kilpper-Blazand, and Staphylococcus aureus Rosenbach; the highest antibacterial activities found in pseudarflavone A and 6-prenylpinocembrin [ 27 ].…”

Section: Effects Of Plant Flavonoids and Other Phenolics On Human mentioning

confidence: 99%

“…Similarly, Pseudarthria hookeri Wight and Arn which has been used as traditional herbal medicine in Africa [ 26 , 27 ] for the treatment of pneumonia, abdominal pains, cough and diarrhea. According to the antibacterial study of this medicinal species, Dzoyem and his team found that flavonoids from this plant showed the highest antibacterial effect against both gram-positive and gram-negative bacteria e.g., E. coli , Klebsiella pneumonia (Schroeter) Trevisan, Pseudomonas aeruginosa (Schroeter) Migula, Enterococcus faecalis (Andrew and Horder) Schleifer and Kilpper-Blazand, and Staphylococcus aureus Rosenbach; the highest antibacterial activities found in pseudarflavone A and 6-prenylpinocembrin [ 27 ]. In addition, Rajarathinam and his group found that Pseudomonas aeruginosa (Schroeter) Migula, an important resistant strain that caused many problems in medical treatment can be eliminated by 2-(3′,4′ dihydroxy-phenyl) 3,5,7-trihydroxy-chromen-4-one from the aerial part extract of Trianthema decandra L.; this phytochemical compound showed antibacterial activity against this pathogen comparing to chloremphenical, an antibiotic [ 28 ].…”

Section: Effects Of Plant Flavonoids and Other Phenolics On Human mentioning

confidence: 99%

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

et al. 2018

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Phenolic compounds as well as flavonoids are well-known as antioxidant and many other important bioactive agents that have long been interested due to their benefits for human health, curing and preventing many diseases. This review attempts to demonstrate an overview of flavonoids and other phenolic compounds as the interesting alternative sources for pharmaceutical and medicinal applications. The examples of these phytochemicals from several medicinal plants are also illustrated, and their potential applications in pharmaceutical and medical aspects, especially for health promoting e.g., antioxidant effects, antibacterial effect, anti-cancer effect, cardioprotective effects, immune system promoting and anti-inflammatory effects, skin protective effect from UV radiation and so forth are highlighted.

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Antibacterial activity and cytotoxicity of flavonoids compounds isolated from Pseudarthria hookeri Wight & Arn. (Fabaceae)

Cited by 45 publications

References 14 publications

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids with an Eight‐Membered Lactam Ring from Greenwayodendron oliveri

Comparative In Vitro Evaluation of Antibacterial and Osteogenic Activity of Polysaccharide and Flavonoid Fractions Isolated from the leaves of Saussurea controversa

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

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