Antibacterial Activity and Alkaloid Content ofBerberis thunbergii,Berberis vulgarisandHydrastis canadensis

Villinski, Jacquelyn R.; Dumas, Elizabeth R.; Chai, Heebyung; Pezzuto, John M.; Angerhofer, Cindy K.; Gafner, Stefan

doi:10.1080/13880200390500768

Cited by 75 publications

(44 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, infusions obtained from berberine-producing plants are used for their antimicrobial, anti-inflammatory, and antiseptic properties. In addition, effects against HIV, osteoporosis, ocular trachoma, and hypertension have been reported (Koo and Seang 1996;Ivanoska and Philipov 1997;Villinski et al 2003;Caraballo et al 2004;Kuo et al 2004;Fatehi et al 2005). The pharmacological activities, particularly the antimicrobial activity, are usually attributed to berberine, although other compounds could be acting synergistically (Stermitz et al 2000a, b).…”

Section: Introductionmentioning

confidence: 94%

In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam

Pitta‐Alvarez

Medina-Bolívar

Álvarez

et al. 2008

In Vitro Cell.Dev.Biol.-Plant

View full text Add to dashboard Cite

Berberis buxifolia Lam., known as "Calafate", is a plant native to Argentina that exhibits antimicrobial activity. This biological activity is attributed to the isoquinoline alkaloid berberine. The aim of this research was to test the antimicrobial properties of different extracts of this species, taking berberine as the reference molecule, and to examine if the expression of bacterial multidrug resistance (MDR) efflux pumps could be responsible for possible resistance mechanisms. To this end, a wild-type and a mutant strain of Staphylococcus aureus with a defective MDR efflux pump were used and the minimum inhibitory concentrations of the extracts were determined. The studies were carried out with infusions of in vivo shoots and "Calafate" commercial tea, as well as with the media derived from shoot cultures incubated with different plant growth regulators (thidiazuron, picloram, and jasmonic acid). As far as antimicrobial activity is concerned, all the extracts tested were significantly more effective than berberine standard. "Calafate" commercial tea and shoot tea had inhibitory concentrations similar to the one observed for ampicillin standard. The media from the shoot cultures, however, were significantly more effective than all the others, particularly the one derived from jasmonic acid, suggesting the presence of compounds that could be acting synergistically with berberine. There were no differences in antimicrobial activity against the wild-type and the mutant S. aureus; no definite conclusions could be drawn concerning the relationship between MDR pumps and possible pathogen resistance to extracts of B. buxifolia.

show abstract

Section: Introductionmentioning

confidence: 94%

In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam

Pitta‐Alvarez

Medina-Bolívar

Álvarez

et al. 2008

In Vitro Cell.Dev.Biol.-Plant

View full text Add to dashboard Cite

show abstract

“…The extracts of B. buxifolia have multiple medicinal applications. They are employed mainly for their antibacterial (Villinski et al 2003) and antidiarrheal properties. However, there are references that mention its use as antispasmodic (Caraballo and Caraballo 2004) and anti-inflammatory.…”

Section: Introductionmentioning

confidence: 99%

Two-stage culture for producing berberine by cell suspension and shoot cultures of Berberis buxifolia Lam

Álvarez

Eraso²,

Pitta‐Alvarez

et al. 2008

Biotechnol Lett

View full text Add to dashboard Cite

In vitro cultures of Berberis buxifolia were established using thidiazuron (4.5, 23 and 45 mM) or picloram (4 and 40 mM) as plant growth regulators for sustaining growth. For producing berberine, a two-stage culture was performed. In the first step, thidiazuron or picloram were used for biomass production followed by the production stage where benzylaminopurine (4.4 mM) was added as a plant growth regulator. Berberine yields (102 mg g(-1) DW) and in vitro shoot cultures (200 mg g(-1) DW) were significantly lower than those of whole plants in the field (416 mg g(-1) DW). The highest productivity (0.18 mg 1(-1) day(-1)) was attained using picloram (either 4 on 40 mM) in the first stage for producing biomass.

show abstract

“…Berberine have demonstrated to have anti-bacterial effect against Vibrio cholera, 11,13,15 Escherichia coli significantly reduces smooth muscle contraction, 12 delays intestinal transistance time in humans 14 Staphylococcus aureus, Leishmania, Proteus, Shigella, Klebsiella, Streptococcus pyogenes. 17,18,19 The anti-bacterial effect may be due to the inhibitory effect of berberine on fimbrial structure formation on the surface of the bacteria. …”

Section: Anti-bacterial Effectsmentioning

confidence: 99%

Therapeutic Aspects of Goldenseal

Asmi¹,

Lakshmi²

2013

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Goldenseal, commonly known as yellow puccoon has wide therapeutic activity. The bioactive components present are isoquinoline alkaloids, hydrastine, berberine and canadine. Berberine is used to treat heart failure also have sedative actions, anti secretory, anti parasitic, anticancerous actions. Hence an attempt was taken to review the pharmacological actions of Goldenseal with respect to its role in dental practice.

show abstract

Antibacterial Activity and Alkaloid Content ofBerberis thunbergii,Berberis vulgarisandHydrastis canadensis

Cited by 75 publications

References 7 publications

In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam

In vitro shoot culture and antimicrobial activity of Berberis buxifolia Lam

Two-stage culture for producing berberine by cell suspension and shoot cultures of Berberis buxifolia Lam

Therapeutic Aspects of Goldenseal

Contact Info

Product

Resources

About