Antibacterial Activity

Bushby, S. R. M.

doi:10.1007/978-3-642-81890-5_5

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1988

1994

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Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode

Goyal

Kumar

1990

Electroanalysis

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The electrochemical oxidation behavior of trimethoprim has been investigated at a pyrolytic graphite electrode over a wide pH range (1.35-10.71). Below pH 3.2, trimethoprim is electrooxidized in two well-defined steps, each involving 4e, 4 H f . Only one well-defined oxidation peak was observed above pH 3.5 however. Products corresponding to each peak have been separated and characterized by thinlayer chromatography (TLC), infra red (IR), and mass spectra. A tentative mechanism associated with the voltammetric oxidation has been proposed to account for the observed experimental behavior. The same product has also been observed during the metabolic oxidation of trimethoprim in albino rats.One of the authors i s thankjid to I<. Gautam, Department of Biosciences, University of Roorkee, jor help in the metabolic studies, Financial help for this work wasprovided hy IJGC, New Delhi, and I.C.M.R. India.

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