Antibacterial activities of trans-cinnamaldehyde, caprylic acid, and β-resorcylic acid against catfish pathogens

Abdelhamed, Hossam; Özdemir, Ozan; Ibrahim, Iman; Lawrence, Mark L.; Karsi, Attila

doi:10.1016/j.aquaculture.2019.02.017

Cited by 23 publications

(17 citation statements)

References 46 publications

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“…The action of TC results in damage of the cell wall and membrane of treated bacteria, and consequently to the loss of inner cell material, cell lysis and leakage of cellular contents [32,33]. Mousavi et al [34] showed also that TC acts as an oxidative stress agent.…”

Section: Discussionmentioning

confidence: 99%

Effect of trans-Cinnamaldehyde on Methicillin-Resistant Staphylococcus aureus Biofilm Formation: Metabolic Activity Assessment and Analysis of the Biofilm-Associated Genes Expression

Kot

Sytykiewicz

Sprawka

et al. 2019

IJMS

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The effects of trans-cinnamaldehyde (TC) on transcriptional profiles of biofilm-associated genes and the metabolic activity of two methicillin-resistant Staphylococcus aureus (MRSA) strains showing a different degree of adherence to polystyrene, were evaluated. Metabolic activity of S. aureus in biofilm was significantly decreased in the presence of TC at 1/2 minimum biofilm inhibition concentration (MBIC). Expression levels of the genes encoding laminin binding protein (eno), elastin binding protein (ebps) and fibrinogen binding protein (fib) in the presence of TC at 1/2 MBIC were lower than in untreated biofilm in both the weakly and strongly adhering strain. The highest decrease of expression level was observed in case of fib in the strongly adhering strain, in which the amount of fib transcript was 10-fold lower compared to biofilm without TC. In the presence of TC at 1/2 MBIC after 3, 6, 8 and 12 h, the expression level of icaA and icaD, that are involved in the biosynthesis of polysaccharide intercellular adhesin, was above half lower in the weakly adhering strain compared to biofilm without TC. In the strongly adhering strain the highest decrease in expression of these genes was observed after 3 and 6 h. This study showed that TC is a promising anti-biofilm agent for use in MRSA biofilm-related infections.

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Section: Discussionmentioning

confidence: 99%

Effect of trans-Cinnamaldehyde on Methicillin-Resistant Staphylococcus aureus Biofilm Formation: Metabolic Activity Assessment and Analysis of the Biofilm-Associated Genes Expression

Kot

Sytykiewicz

Sprawka

et al. 2019

IJMS

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“…salmonicida and of almost all A. sobria strains was inhibited at concentration 0.01 mg/mL, and in case of most A. hydrophila strains, MIC ranged from 0.01 mg/mL to 0.19 mg/mL. Results obtained by Abdelhamed et al [17] showed that TC had better antibacterial activity against A. hydrophila ML09-119 strain than other tested plant-derived compounds and the MIC value was 80 µl/mL. In our study, we investigated activity of TC against 10 A. hydrophila strains and the MIC values varied but in case of five strains they were close to or lower than those obtained by Abdelhamed et al [17].…”

Section: Discussionmentioning

confidence: 94%

“…Results obtained by Abdelhamed et al [17] showed that TC had better antibacterial activity against A. hydrophila ML09-119 strain than other tested plant-derived compounds and the MIC value was 80 µl/mL. In our study, we investigated activity of TC against 10 A. hydrophila strains and the MIC values varied but in case of five strains they were close to or lower than those obtained by Abdelhamed et al [17]. TC is a phenolic compound extracted from bark of cinnamon that shows low toxicity and is recognized and classified as safe for addition to foods by the U.S. Food and Drug Administration [18].…”

Section: Discussionmentioning

confidence: 98%

“…TC is a phenolic compound extracted from bark of cinnamon that shows low toxicity and is recognized and classified as safe for addition to foods by the U.S. Food and Drug Administration [18]. The research conducted by Abdelhamed et al [17] showed that all intestinal fragments from catfish fed TC-supplemented diets at 10, 20, 30, and 40 mg/kg were healthy with no signs of ulcer, necrotic enterocytes, and inflammation. Moreover, these studies showed that the addition of TC to the catfish diet increased the number of goblet cells, which are responsible for synthesis and secretion of mucins that form a mucus layer on the intestine surface.…”

Section: Discussionmentioning

confidence: 99%

“…The cytotoxicity of cinnamaldehyde was also determined by Ribeiro et al [23] by using a fibroblast cell line, and the results showed that cinnamaldehyde did not compromise fibroblast cell viability. It was observed that action of TC results in damage of cell wall and membrane of treated bacteria, and consequently to loss of inner cell material, cell lysis and leakage of cellular contents [17,24]. TC exhibits significant antimicrobial properties against various pathogens, including uropathogenic Escherichia coli [25], methicillin-resistant Staphylococcus aureus [26] and other Gram-positive and Gram-negative bacteria [27].…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial Activity of Commercial Phytochemicals against Aeromonas Species Isolated from Fish

et al. 2019

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Antimicrobial activities of phytochemicals—trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), chlorogenic acid (CHA), Thymus vulgaris essential oil (TO), Eugenia caryophyllus essential oil (ECO), and Melaleuca alternifolia oil (TTO) against Aeromonas species—were assessed. Growth of all Aeromonas salmonicida subsp. salmonicida and almost all Aeromonas sobria strains was inhibited by TC at concentration 0.01 mg/mL, and for most Aeromonas hydrophila strains minimal inhibitory concentrations (MIC) ranged from 0.01 to 0.19 mg/mL. The inhibitory effect of TC against A. salmonicida subsp. salmonicida was comparable to the effect of oxytetracycline, and in the case of A. salmonicida subsp. salmonicida and A. sobria was higher compared to gentamicin. MIC of FA, p-CA, and CA for most strains ranged from 1.56 to 3.12 mg/mL, and MIC values of TO for most strains ranged from 0.39 to 0.78 mg/mL. TO and TC at the concentrations below ½ MIC values used in mixtures exhibited strong synergism. ECO and TC showed synergy in mixture of ⅛ MIC of ECO and ¼ MIC of TC. TC and TO exhibited the strongest inhibitory and bactericidal effect against investigated Aeromonas species, and they are a promising alternative to the use of antibiotics in controlling the growth of these fish pathogens.

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Influence of p-coumaric acid, as a medicinal plant phenolic compound, on expression of virulence genes and pathogenicity of Aeromonas hydrophila in common carp

et al. 2022

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Antibacterial activities of trans-cinnamaldehyde, caprylic acid, and β-resorcylic acid against catfish pathogens

Cited by 23 publications

References 46 publications

Effect of trans-Cinnamaldehyde on Methicillin-Resistant Staphylococcus aureus Biofilm Formation: Metabolic Activity Assessment and Analysis of the Biofilm-Associated Genes Expression

Effect of trans-Cinnamaldehyde on Methicillin-Resistant Staphylococcus aureus Biofilm Formation: Metabolic Activity Assessment and Analysis of the Biofilm-Associated Genes Expression

Antibacterial Activity of Commercial Phytochemicals against Aeromonas Species Isolated from Fish

Influence of p-coumaric acid, as a medicinal plant phenolic compound, on expression of virulence genes and pathogenicity of Aeromonas hydrophila in common carp

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