Antibacterial Activities of Some Wild Mushroom Extracts Against Pseudomonas Aeruginosa

Nikolovska-Nedelkoska, Daniela; Atanasova-Pancevska, Natalija; Karadelev, Mitko; Uzunoska, Zora; Kungulovski, Dz.

doi:10.55302/jafes18723067nn

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“…According to the World Health Organization, the treatment and safe measures for gastrointestinal disorders are highly valued in various traditional medical practices. The charcoal meal experiment in mice is a way to determine the impact of medicines on intestinal motility [34]. Anti-inflammatory activity of Trametes hirsuta ethanol extract at a dose of 300mg/kg after 60min showed significant result followed by the dose of 150mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Exploring the pharmacological potential of Trametes hirsuta (White Rot Fungi): Analgesic, anti-Inflammatory, antispasmodic and antimicrobial activities

Begum¹

2023

PAB

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A healthy and well-balanced diet is essential for illness prevention, especially when it comes to oxidative stress. Mushrooms have been utilized in oriental medication for centuries to prevent and treat a variety of diseases. Mushroom extracts are increasingly available as dietary supplements, especially to increase immune function. In current study, the pharmacological potential of Trametes hirsuta was investigated, specifically its analgesic, anti-inflammatory, and antispasmodic activity, as well as its antimicrobial activity. Ethanolic extracts of T. hirsuta were used for the pharmacological studies, while aqueous extracts were used for myco-chemical analysis. In the analgesic activity, a dose of 300mg/kg of the ethanol extract was administered, resulting in a reduction of writhing to (21.33±88) /5min and 46.21% inhibition, compared to the standard diclofenac sodium which reduced writhing to (19.66±1.20) /5min and showed 50.42% inhibition. For anti-inflammatory activity, T. hirsuta extract was given at a dose of 300mg/kg after 240min showed (1.13±0.57) as compared to the standard drug aspirin (1.10±0.57). The ethanolic extract of Trametes hirsuta revealed highest (59.43%) antispasmodic activity at 300 mg/kg concentration followed by the same extract (54.33%) at 150mg/kg concentrations. The standard drug buscopan showed concentrated antispasmodic effect (65.21 %) as compared to the wood rotting fungi extracts. The ethanol extract of Trametes hirsuta has a strong antispasmodic effect via slowing intestinal motility. The antimicrobial activity study showed that all selected wood rotting fungi extracts were effective against different selected bacterial strains The highest antibacterial activity was detected against Staphylococcus aureus (16.00±0.66 mm) followed by Klebisella pneumonia. (14.66±0.88 mm) and Salmonella enterica (13.00±0.88 mm) at concentration of 20mg/disc.Analysis of the data show that extracted samples of Trametes hirsuta inhibited the growth by 11.33±0.33 mm,11.33±0.57 mm and 10.33±0.57 mm at meditation of 10 mg/disc respectively. The present study suggests that not only angiosperms and gymnosperms, but fungi as well, can be a valuable source of chemical compounds for treating acute and chronic diseases. This study provides a baseline information for future research.

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Section: Discussionmentioning

confidence: 99%

Exploring the pharmacological potential of Trametes hirsuta (White Rot Fungi): Analgesic, anti-Inflammatory, antispasmodic and antimicrobial activities

Begum¹

2023

PAB

View full text Add to dashboard Cite

show abstract

Antibacterial Activities of Some Wild Mushroom Extracts Against Pseudomonas Aeruginosa

Cited by 1 publication

References 0 publications

Exploring the pharmacological potential of Trametes hirsuta (White Rot Fungi): Analgesic, anti-Inflammatory, antispasmodic and antimicrobial activities

Exploring the pharmacological potential of Trametes hirsuta (White Rot Fungi): Analgesic, anti-Inflammatory, antispasmodic and antimicrobial activities

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