Antiatheromatic and hypolipidemic activity of Chios Mastic Gum in anesthetized rabbits

Paraschos, S.; Andreadou, Ioanna; Iliodromitis, Efstathios K.; Ζώγα, Αναστασία; Magiatis, Prokopios; Mitaku, Sofia; Kaklamanis, Loukas; Skaltsounis, AL; Kremastinos, Dimitrios Th.

doi:10.1055/s-0028-1084340

Cited by 5 publications

(5 citation statements)

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“…The absence of any statistical significant effect on LDL-cholesterol and on triglycerides levels is in contrast to all the aforementioned literature, where LDL reduction was a stable finding in animals. 13,17,18 Triantafyllou et al. 19 also showed some degree of LDL reduction, but with a much higher mastic powder dose (5 g compared to 2 g in this study).…”

Section: Discussionsupporting

confidence: 43%

“…22,23 Some CMG triterpenic constituents could act as α-glucosidase inhibitors, 24 while others demonstrate phytosterolic effects. 18,25 Triterpenes are also known to exert beneficial effects on pancreatic b-cells, enhancing insulin secretion, and to inhibit protein tyrosine phosphatase-1B (PTP-1B) enhancing insulin action. 26…”

Section: Discussionmentioning

confidence: 99%

“…Administration of CMG in hypercholesterolemic rabbits resulted in reduced total cholesterol levels and prevented subintimal accumulation of lipids and foamy macrophages. 18 Peripheral anti-inflammatory and anti-oxidant activities of CMG have also been reported in the limbs of mice and rats, although the mechanism of action was not fully elucidated. 14 Vallianou et al.…”

Section: Discussionmentioning

confidence: 99%

“…CMG is a natural anti-oxidant, extremely efficient in preventing LDL oxidation in vitro 15,16 and its hypolipidemic effect has been demonstrated in animal 13,17,18 and human 19 studies. CMG could be a potential anti-diabetic agent, as is the case with many other natural products rich in terpenes, 17,19 and exhibits remarkable anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS-MASTIHA)

Kartalis¹,

Didagelos²,

Georgiadis³

et al. 2015

Eur J Prev Cardiolog

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Section: Discussionsupporting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS-MASTIHA)

Kartalis¹,

Didagelos²,

Georgiadis³

et al. 2015

Eur J Prev Cardiolog

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“…A few years ago, mastic gum was specifically reported to be effective against Helicobacter pylori in vitro and in vivo [5], against Crohnʼs disease [6], colon cancer [7], and prostate cancer [8,9]. Mastic gum has also been found to exhibit antiatheromatic and hypolipidemic activity [10,11], to modulate serum pa-Abstract ! Chios mastic gum, the resin obtained as an exudate from the trunk and branches of Pistacia lentiscus L var.…”

mentioning

confidence: 99%

Oral Administration of Chios Mastic Gum or Extracts in Mice: Quantification of Triterpenic Acids by Liquid Chromatography-Tandem Mass Spectrometry

et al. 2011

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Chios mastic gum, the resin obtained as an exudate from the trunk and branches of Pistacia lentiscus L var. chia, is used extensively as a constituent of herbal drugs or functional foods. The oral absorption of its major constituents still remains unclear. In the context of identifying the features of mastic gum that are responsible for either therapeutic effects or effects of nutritional value, a methodology based on high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (MS/MS) was developed and applied for the quantification of mastic gum triterpenic acids, 24Z-isomasticadienonic acid (IMNA), and 24Z-isomasticadienolic acid (IMLA) in mouse plasma. The specific compounds were selected based on their biological activity and potential against Helicobacter pylori. Concentrations were determined simultaneously in mouse plasma after oral administration of mastic gum or total mastic extract without polymer (TMEWP) in order to evaluate the role of the natural polymer, poly-β-myrcene, in the absorption process. Following TMEWP administration in mice, circulating IMNA and IMLA plasma levels were significantly higher (approximately 10-fold) in comparison to IMNA and IMLA plasma levels following total mastic gum administration (CMG), suggesting that the polymer plays a critical role in the absorption process. More specifically following TMEWP administration, Cmax plasma values were 3300 ± 859 ng/mL for IMNA and 163 ± 58 ng/mL for IMLA. In comparison, following CMG administration, Cmax plasma values were 329 ± 57 ng/mL for IMNA and 28 ± 8 ng/mL for IMLA. The methodological approaches presented in this study, along with the findings, offer valuable information on the availability of bioactive components following ingestion of mastic and facilitate the uses of mastic either as an ingredient of functional foods or as a herbal drug.

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Effects of Chios Mastiha essential oil on cholesterol levels of healthy volunteers: A prospective, randomized, placebo-controlled study (MASTIHA-OIL)

Kartalis,

Afendoulis,

Didagelos

et al. 2024

Hellenic Journal of Cardiology

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Antiatheromatic and hypolipidemic activity of Chios Mastic Gum in anesthetized rabbits

Cited by 5 publications

References 0 publications

Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS-MASTIHA)

Effects of Chios mastic gum on cholesterol and glucose levels of healthy volunteers: A prospective, randomized, placebo-controlled, pilot study (CHIOS-MASTIHA)

Oral Administration of Chios Mastic Gum or Extracts in Mice: Quantification of Triterpenic Acids by Liquid Chromatography-Tandem Mass Spectrometry

Effects of Chios Mastiha essential oil on cholesterol levels of healthy volunteers: A prospective, randomized, placebo-controlled study (MASTIHA-OIL)

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