Antiarthritic Activity of Achyranthes Aspera on Formaldehyde - Induced Arthritis in Rats

Abstract

AIM:To determine the ameliorative potential of aqueous extract of Achyranthesaspera(AEAA) against arthritis using swiss albino mice and Wistar rats, and its possible mechanism of action.METHODS:Swiss albino mice (25-30 g) and Wistar rats (150-180 g) under standard controlled conditions (24 ± 2°C, 50-70 humidity and 12 h light/dark cycle). The groups were divided into 6 groups (n = 6/group) and assigned as control, negative control, standard and, formaldehyde supplemented with two different test dose groups of A. aspera for 4 weeks. Arthritis induced by subplantar administration of 0.1 ml formaldehyde (2% v/v) into the left hind paw in all groups except normal control. Arthritis was assessed using serum Hb, ESR, paw volume, joint diameter, radiological and histopathological investigation.RESULTS:Oral administration of AEAA shown a significant (p < 0.01) dose-dependent protection against formaldehyde induced arthritis. At 21st day, A.asperashown an inhibition of paw volume in the different doses of 250 mg/kg and 500 mg/kg were found to be 30% and, 38.33% respectively. At 14th day the joint swelling was found to be 27.2% and 36.36 respectively. Diclofenac (10 mg/kg) had an effect of 36.61% inhibition of arthritis and joint swelling at 21st and 14th day.CONCLUSION:Thus, the present study revealed that the aqueous extract of A. aspera offered significant protection against arthritis and joint inflammation.

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

“…Routinely, nonsteroidal antiinflammatory drugs (NSAIDs), slow-acting antirheumatic drugs, steroids, biologics, and disease-modifying antirheumatic drugs are prescribed to combat RA 7 ; however, all these drugs provide symptomatic relief. 8,9 These therapies adversely affect vital organs and instigate ulceration, hypertension, and stroke. The modern world is turning to herbal therapy because of drug resistance, organ toxicity, and high cost presented by these therapies.…”

“…The presence of reactive oxygen species (ROS) and other free radicals also contribute to the pathogenesis of RA. Routinely, nonsteroidal anti‐inflammatory drugs (NSAIDs), slow‐acting antirheumatic drugs, steroids, biologics, and disease‐modifying antirheumatic drugs are prescribed to combat RA; however, all these drugs provide symptomatic relief . These therapies adversely affect vital organs and instigate ulceration, hypertension, and stroke.…”

Determination of Suitable Nursery Growth Media for Cardamom (&lt;i&gt;Eletteria cardamomum &lt;/i&gt;Maton.) Seedlings at Teppi, Southwestern Ethiopia

“…Then, all data were subjected to analysis of variance (ANOVA) using SAS software [25]. The means comparison and separation were done by using the LSD (List Significance Difference) range test at a 5% level of significance [6,12].…”

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

“…The ethanolic extract of the whole plant has shown its antiarthritic activity in Freund's complete adjuvant-induced arthritis [131]. The aqueous extract of A.aspera reported providing protection against formaldehyde-induced arthritis and joint inflammation in rats [132].…”