Antiarthritic Activity of a Polysaccharide-Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae) in Freund's Complete Adjuvant - Induced Arthritic Rats

Protective effect of polysaccharide-protein complex from a polypore mushroom,Phellinus rimosusagainst radiation-induced oxidative stress

“…The voucher specimen was deposited in the Herbarium of Centre for Advanced Studies in Botany, University of Madras, Chennai, India (HERB MUBL 3171). PPC-Pr was isolated from the aqueous extract of P. rimosus by the method described by Meera et al [15][16][17] Estimation of in vitro DNA damage…”

“…13,14 Our recent investigations have demonstrated profound antioxidant, antiinflammatory, antiarthritic, as well as radioprotective activities of a polysaccharide protein complex (PPC-Pr) isolated from the aqueous extract of P. rimosus. [15][16][17] The aim of our present study is to investigate the protective effect of PPC-Pr complex against radiation-induced DNA damage, tissue oxidative stress, as well as survival of the organism.…”

The role of edible mushrooms in health: Evaluation of the evidence

“…The antioxidant enzymes superoxide dismutase and glutathione peroxidase were elevated in adjuvant-induced rats, and reduced blood glutathione was decreased. Treatments with various concentrations of the polysaccharide-protein complex modulated the alterations produced in arthritic animals in a dose-dependent manner (Meera, Smina, Balan, Mathew, & Janardhanan, 2009). Anti-arthritic activity of a beta-(1,3/1,6)-D-glucan from P. ostreatus has been reported (Bauerova, Paulovicova, Mihalova, Svik, & Ponist, 2009;Rovensky, Stancikova, Svik, Bauerova, & Jurcovicova, 2011) in a rat model which involved an immunomodulating effect on cytokine plasma levels that changed markedly with arthritis progression.…”