Antiarrhythmic effects of (−)-epicatechin-3-gallate, a novel sodium channel agonist in cultured neonatal rat ventricular myocytes

Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat

“…These observation for OPP are in agreement with several other plant extracts and isolated polyphenols and flavonoids reported to exert biological actions on various cardiac (Fang et al, 2011;Wallace, Baczko, Jones, Fercho, & Light, 2006;Wu, Loh, Cheng, Lu, & Lin, 2013) and vascular smooth muscle cell preparations including modulation of contractility (Diebolt & Andriantsitohaina, 2002;Protic et al, 2013;Zhu, Wang, Ou, Han, & Li, 2013). Several polyphenols exert their effects on contractility usually by modulation of ion channels (Protic et al, 2013;Tadano et al, 2010;Wu et al, 2013) and other important pathways linked to motility in health and disease (Abe et al, 2012).…”

“…For example, recent studies have identified a range of beneficial biological outcomes of oil palm phenolics (OPP) including antioxidant, antiinflammatory, anti-diabetic, neuro-protective as well as vascular protective qualities (Abeywardena et al, 2002;Bolsinger, Pronczuk, Sambanthamurthi, & Hayes, 2014;Leow, Sekaran, Sundram, Tan, & Sambanthamurthi, 2013a;Leow, Sekaran, Tan, Sundram, & Sambanthamurthi, 2013b;Nasef, Mehta, Murray, Marlow, & Ferguson, 2014;Sambanthamurthi et al, 2011). These observation for OPP are in agreement with several other plant extracts and isolated polyphenols and flavonoids reported to exert biological actions on various cardiac (Fang et al, 2011;Wallace, Baczko, Jones, Fercho, & Light, 2006;Wu, Loh, Cheng, Lu, & Lin, 2013) and vascular smooth muscle cell preparations including modulation of contractility (Diebolt & Andriantsitohaina, 2002;Protic et al, 2013;Zhu, Wang, Ou, Han, & Li, 2013). Several polyphenols exert their effects on contractility usually by modulation of ion channels (Protic et al, 2013;Tadano et al, 2010;Wu et al, 2013) and other important pathways linked to motility in health and disease (Abe et al, 2012).…”

Concomitant SK current activation and sodium current inhibition cause J wave syndrome

“…Patch clamp studies to determine the effects of CyPPA on I Na . A whole-cell patch clamp technique was performed as described elsewhere (46). Briefly, the isolated ventricular cardiomyocytes were superfused with bath solution containing (in mmol/l) 137 NaCl, 5.4 KCl, 1.0 CaCl 2 , 0.5 MgCl 2 , 10 glucose, and 10 HEPES,…”

Activation of voltage‐gated sodium current and inhibition of erg‐mediated potassium current caused by telmisartan, an antagonist of angiotensin II type‐1 receptor, in HL‐1 atrial cardiomyocytes

“…Thus, proposing that direct stimulation of I Na and inhibition of I K(erg) by the drug produce beneficial effects on patients with heart failure or bradyarrhythmias is tempting. 19,21 In this regard, an antagonistic effect of a combination of chronic TEL and acute Ran or Amio on I Na may potentially exist and care must be appropriately exercised by patients taking TEL because the drug could attenuate the action of Ran or Amio on I Na . Additionally, both TEL and Ran have been reported to be effective in treating atrial fibrillation; 11,22,25,42,43 therefore, the differential mechanism for the action of these 2 drugs existing in atrium must be further delineated in the near future.…”

“…18 Na V 1.5 channels primarily underlie AP initiation and propagation in the heart, and these channels have recently been shown to be critical determinants of action potential duration (APD), particularly in the setting of certain arrhythmias. [19][20][21][22][23][24][25] Inherited mutations in SCN5A, the gene coding for Na V 1.5, are known to underlie congenital long QT syndrome (LQT-3) and Brugada syndrome, 2 inherited cardiac disorders linked to syncope, ventricular tachycardia, and sudden death; 19 in most cases, these inherited mutations perturb channel inactivation with a residual inward sustained I Na . Fast inactivation of Na V channels, which occurs within milliseconds of membrane depolarization, is due to rapid block of the inner mouth of the channel pore by a cytoplasmic linker between domains III and IV.…”