Antiarrhythmic effects of adenosine on ischemia-induced ventricular fibrillation

Stark, Ulrike; Brodmann, Marianne; Lueger, Andreas; Stärk, Gerhard

doi:10.1053/jcrc.2001.21791

Cited by 12 publications

(8 citation statements)

References 21 publications

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“…For patients treated with thienopyridines, the crossover rate was significantly lower at 5 and 6% for clopidogrel and prasugrel, respectively. This phenomenon might be explained by the fact that the side effect profile of ticagrelor is inferior to that of prasugrel and clopidogrel due to a reported higher incidence of dyspnea [7], ventricular pauses [20], and anxiety [21]. Conversely, the lower discontinuation rate of therapy with clopidogrel and prasugrel was comparable and did not differ.…”

Section: Discussionmentioning

confidence: 99%

Real-World Use of Novel P2Y12 Inhibitors in Patients with Acute Myocardial Infarction: A Treatment Paradox

et al. 2016

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Objective: To assess the real-world use, clinical outcomes, and adherence to novel P₂Y₁₂ inhibitors. Methods: We evaluated 1,093 consecutive acute myocardial infarction patients undergoing a percutaneous intervention. Patients were derived from a prospective, multicenter, nationwide registry and were followed for 30 days; 381 patients (35%) received clopidogrel, 468 (43%) received prasugrel, and 244 (22%) received ticagrelor. Patients treated with clopidogrel were older and more likely to suffer from chronic renal failure and stroke and/or present with non-ST-elevation myocardial infarction (NSTEMI) (p < 0.01 for all). Independent predictors of undertreatment with novel P₂Y₁₂ inhibitors included: older age (OR 0.17; 95% CI 0.1-0.27, p < 0.0001), a prior stroke (OR 0.41; 95% CI 0.2-0.68, p = 0.008), and NSTEMI (OR 0.37; 95% CI 0.26-0.54, p < 0.0001). Results: Novel P₂Y₁₂ inhibitors were associated with a lower incidence of cardiovascular events, major bleeding, and/or death (7.6 vs.11%, HR 0.67; 95% CI 0.43-1, p = 0.05). However, after a multivariate analysis this trend was not statistically significant. Patients discharged with ticagrelor versus thienopyridines demonstrated a higher rate of crossover to other P₂Y₁₂ inhibitors (11 vs. 5%, p = 0.03). Conclusions: In a real-world cohort, there was an underutilization of novel P₂Y₁₂ inhibitors which was more pronounced in higher-risk subsets that might benefit from novel P₂Y₁₂ inhibitors at least as much as other patients.

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Section: Discussionmentioning

confidence: 99%

Real-World Use of Novel P2Y12 Inhibitors in Patients with Acute Myocardial Infarction: A Treatment Paradox

et al. 2016

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“…Chemical standards of adenine (1), guanine (2), xanthine (3), thymine (10), inosine (13), arginine (15), histidine (16), lysine (17), tyrosine (20), valine (21), proline (22), glutamate (24), serine (27), threonine (28), alanine (29), tryptophan (31), phenylalanine (32), leucine (34), isoleucine (35), aspartic acid (37), 1-deoxynojirimycin (DNJ) (39), and fagomine (40) were purchased from the National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China. Reference compounds of cytidine-5 -monophosphate (4), 2 -deoxyguanosine (5), 2 -deoxyuridine (8), 2 -deoxyinosine (9), cytidine (11), 2 -deoxyadenosine-5 monophosphate (12), thymidine (14), ornithine (18), hydroxyproline (19), citrulline (23), glutamine (25), asparagine (26), glycine (30), ␥-aminobutyric acid (36), and cysteine (38) were obtained from Sigma (St. Louis, MO). Chemical standards of 2 -deoxyadenosine (6) and 2 -deoxycytidine (7) were obtained from Aladdin Chemical, Shanghai, China.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

“…It is also well known that nucleosides [15][16][17] and amino acids [18][19][20][21] are involved in the regulation and modulation of various physiological processes in body and exhibit multiple bioactivities, such as antiplatelet aggregation, antiarrhythmic, antioxidant, and so on [22][23][24][25][26][27][28][29]. 1-Deoxynojirimycin, one of the alkaloids in mulberry leaf, is an ␣-glucosidase inhibitor [30], which is effective for diabetes [31].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantitation of nucleosides, nucleobases, amino acids, and alkaloids in mulberry leaf by ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry

Zhang

Bai

Shu

et al. 2014

J of Separation Science

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An ultra high performance liquid chromatography coupled with a triple quadrupole mass detection and electrospray ionization mass spectrometry method has been established for the simultaneous determination of the 14 nucleosides and nucleobases, 24 amino acids and two main alkaloids in mulberry leaf. In this method, a complicated mobile phase, the flow rate of which was 0.4 mL/min, was applied to the gradient elution, which provided a satisfied separation of the 40 compounds. The present method was validated, and sufficient reproducibility and accuracy were obtained for the quantitative measurement of the 40 compounds. The method was subsequently applied to ten mulberry leaves and the results showed that almost all of these samples were rich in nucleosides, nucleobases, amino acids, and alkaloids. The proposed method, which is convenient and economical, could serve as a prerequisite for the quality control of mulberry leaf herbs and be applied analogously to other Chinese medicines.

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“…In addition, specific A 1 receptor agonist 2-chloro-N 6 -cyclopentyladenosine produced comparable antiarrhythmic effects as those observed in the presence of adenosine alone. The authors concluded that the antiarrhythmic effects of adenosine are directly modulated by the A 1 receptor (45). In contrast, Schreleck and Richardt (42) concluded that endogenous adenosine is antiarrhythmic during ischemia via the actions on A 2A receptors.…”

Section: Discussionmentioning

confidence: 99%

Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats

Collins¹,

DiCarlo²

2005

American Journal of Physiology-Heart and Circulatory Physiology

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Collins, Heidi L., and Stephen E. DiCarlo. Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats. Am J Physiol Heart Circ Physiol 289: H1020 -H1026, 2005. First published May 6, 2005; doi:10.1152/ajpheart.00156.2005.-Coronary artery occlusioninduced tachyarrhythmias that culminate in ventricular fibrillation are the leading cause of death in developed countries. The intrinsic adenosine receptor system protects the heart from an ischemic insult. Thus the increased functional demands made on the heart during exercise may produce protective adaptations mediated by endogenous adenosine. Therefore, we tested the hypothesis that a single bout of dynamic exercise increases the ventricular arrhythmia threshold (VAT) induced by coronary artery occlusion in conscious hypertensive rats via the intrinsic adenosine receptor system. To test this hypothesis, we recorded the VAT before and on an alternate day after a single bout of dynamic treadmill exercise (12 m/min, 10% grade for 40 min). A single bout of dynamic exercise significantly reduced postexercise arterial pressure (⌬Ϫ24 Ϯ 4 mmHg) and increased VAT (⌬ϩ1.95 Ϯ 0.31 min). Adenosine receptor blockade with the nonselective adenosine receptor antagonists theophylline or aminophylline (10 mg/kg) attenuated the cardioprotective effects of a single bout of dynamic exercise. Results suggest that strategies that increase myocardial ATP requirements leading to adenosine production provide protection against coronary artery occlusion. coronary artery occlusion; cardioprotective strategies THE CARDIOVASCULAR RESPONSE to dynamic, whole body exercise places profound demands on the heart. For example, cardiac output can increase four-to fivefold. The increase in cardiac output is primarily mediated by an increase in heart rate (HR) and to a lesser extent by an increase in stroke volume. The increase in stroke volume is primarily mediated by an increase in end-diastolic volume (Frank-Starling mechanism) and, in part, to a reduction in end-systolic volume (increased contractility mediated by adrenergic stimulation). These cardiovascular responses markedly increase myocardial oxygen consumption and accordingly, coronary blood flow can increase four-to fivefold (46). There is a tight relationship between myocardial oxygen consumption and coronary blood flow that suggests that products of metabolism mediate local control of coronary blood flow. Adenosine, a breakdown product of ATP, has been proposed as the major mediator of local coronary blood flow (3). Specifically, adenosine is the vasodilatory metabolite that links coronary blood flow to myocardial metabolism (3).Adenosine also has an important role as an endogenous determinant of ischemic tolerance by modulating several components of cardiac function (6, 41). For example, adenosine has potent cardiac electrophysiological effects, including a negative chronotropic action on the sinus node and a predominant negative dromotropic action on the atriovent...

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Antiarrhythmic effects of adenosine on ischemia-induced ventricular fibrillation

Cited by 12 publications

References 21 publications

Real-World Use of Novel P2Y12 Inhibitors in Patients with Acute Myocardial Infarction: A Treatment Paradox

Real-World Use of Novel P2Y12 Inhibitors in Patients with Acute Myocardial Infarction: A Treatment Paradox

Simultaneous quantitation of nucleosides, nucleobases, amino acids, and alkaloids in mulberry leaf by ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry

Acute exercise increases the ventricular arrhythmia threshold via the intrinsic adenosine receptor system in conscious hypertensive rats

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