Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation

Tagami, Takashi; Yasunaga, Hideo

doi:10.1186/s13054-017-1639-8

Cited by 7 publications

(17 citation statements)

References 37 publications

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“…There was no saline placebo having its effect compared to antiarrhythmic drugs (Table 4). We analyzed three retrospective studies, one from a multicenter study conducted in the USA 15 , one from the Japanese Diagnosis Procedure Combination inpatient database 7 and one from the Taiwan's National Health Insurance Research Database (NHIRD) 16 . August 1, 2000, the start date for data collection of Rea et al 15 study, is the date of the publication of the 2000 guidelines recommending amiodarone over lidocaine for VF/ pVT.…”

Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

“…b) Participants Table 6 and 7 summarizes the characteristics of participants of chosen clinical trials and retrospective studies, respectively. In all included studies 2,7,13,14,16 , patients were eligible if they were adults with non-traumatic OHCA, except in the study of Rea et al 15 , that compared survival rates of in-hospital cardiac arrest treated with amiodarone or lidocaine or a combination of both. In the studies of Kudenchuk et al 13,14 , patients presenting with initial shock-refractory VF/VT were reported and analyzed in the research published in 2016 13 .…”

Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

“…In retrospective studies 7,15,16 , there was a lack of information about the cardiac arrest event and the treatment they received before the administration of antiarrhythmic drugs.…”

Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

“…Ventricular fibrillation (VF) and pulseless ventricular tachycardia (pVT) are the most common cause of cardiac arrest, being responsible for approximately 85% of sudden cardiac deaths 5 . Both conditions are treated primarily by cardiopulmonary resuscitation (CPR) 6 and electrical defibrillation, and therefore, have better outcomes when compared to other causes of cardiac arrest that do not respond to this kind of procedure (for example, asystole) 7 .…”

Section: Introductionmentioning

confidence: 99%

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Comparison between amiodarone and lidocaine for ventricular fibrillation treatment during cardiopulmonary resuscitation

Shin¹,

Borges²,

Souza³

2020

Rev. Med. (São Paulo)

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Cardiac arrest is a condition in which the heart mechanical functioning is compromised and usually it is due an electrical dysfunction of the cardiac cells and this can result in disorganization of cardiac rhythm and even heart failure, a situation of medical emergency in which seconds can make the difference between life and death. In cardiac arrest, it’s necessary to perform cardiopulmonary resuscitation (CPR) maneuver and, if there are shockable rhythms (such as ventricular fibrillation and pulseless ventricular tachycardia), defibrillation should be administered on the patient. Even if the cardiac rhythm is reestablished, the condition is still serious due to the risk of recurrent electrical alteration of the heart. With the intent of avoiding a new rhythmic alteration of the heart, it’s ministered antiarrhythmic drugs, such as amiodarone or lidocaine. Eventhough the use of one of these drugs is recommended, there are no consensuses about which one has higher survival rate of patients or which has the highest rate of return of spontaneous circulation. Thus, this systematic review aims to clarify which one of these two drugs is more efficient at preventing new electrical alterations of patients post cardiorespiratory arrest.

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Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

“…In retrospective studies 7,15,16 , there was a lack of information about the cardiac arrest event and the treatment they received before the administration of antiarrhythmic drugs.…”

Section: Characteristics Of Included Studies A) Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison between amiodarone and lidocaine for ventricular fibrillation treatment during cardiopulmonary resuscitation

Shin¹,

Borges²,

Souza³

2020

Rev. Med. (São Paulo)

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“…Antiarrhythmic drugs work on sodium, calcium, and/or potassium channels, and therefore modify the defibrillation threshold [1]. Amiodarone induces a prolonged hypotension, this effect being mainly linked to its solvent, whereas lidocaine causes a concentration-dependent increase in defibrillation energy requirements and a negative inotropic effect.…”

mentioning

confidence: 99%

Antiarrhythmic drugs in out-of-hospital cardiac arrest: is there a place for potassium chloride?

Jouffroy

Vivien

2017

Crit Care

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Cardiac arrhythmias in the emergency settings of acute coronary syndrome and revascularization: an European Heart Rhythm Association (EHRA) consensus document, endorsed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Acute Cardiovascular Care Association (ACCA)

et al. 2019

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Despite major therapeutic advances over the last decades, complex supraventricular and ventricular arrhythmias (VAs), particularly in the emergency setting or during revascularization for acute myocardial infarction (AMI), remain an important clinical problem. Although the incidence of VAs has declined in the hospital phase of acute coronary syndromes (ACS), mainly due to prompt revascularization and optimal medical therapy, still up to 6% patients with ACS develop ventricular tachycardia and/or ventricular fibrillation within the first hours of ACS symptoms. Despite sustained VAs being perceived predictors of worse in-hospital outcomes, specific associations between the type of VAs, arrhythmia timing, applied treatment strategies and long-term prognosis in AMI are vague. Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia that may be asymptomatic and/or may be associated with rapid haemodynamic deterioration requiring immediate treatment. It is estimated that over 20% AMI patients may have a history of AF, whereas the new-onset arrhythmia may occur in 5% patients with ST elevation myocardial infarction. Importantly, patients who were treated with primary percutaneous coronary intervention for AMI and developed AF have higher rates of adverse events and mortality compared with subjects free of arrhythmia. The scope of this position document is to cover the clinical implications and pharmacological/non-pharmacological management of arrhythmias in emergency presentations and during revascularization. Current evidence for clinical relevance of specific types of VAs complicating AMI in relation to arrhythmia timing has been discussed.

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Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation

Cited by 7 publications

References 37 publications

Comparison between amiodarone and lidocaine for ventricular fibrillation treatment during cardiopulmonary resuscitation

Comparison between amiodarone and lidocaine for ventricular fibrillation treatment during cardiopulmonary resuscitation

Antiarrhythmic drugs in out-of-hospital cardiac arrest: is there a place for potassium chloride?

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