Antiarrhythmic drugs and anaesthesia: part 1. mechanisms of cardiac arrhythmias

Kim, C.J.; Lever, N.; Cooper, J.O.

doi:10.1016/j.bjae.2022.11.001

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Intrinsic differences in the action potential duration of endocardial, mid-myocardial (M cells) and epicardial cells contribute to a physiological phenomenon known as ventricular transmural dispersion of repolarization (TDR). This heterogeneity of action potentials across different layers of the ventricular myocardium is due to a variable expression of ion channels and explains the reason why the repolarization process occurs unevenly in the heart ( 89 ). Even in the absence of abnormal anatomical substrates, cardiomyocytes exist in different states of excitability and refractoriness across the ventricular wall, generating different excitable myocardial areas, resulting in an increased TDR.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of propofol and alfaxalone on the electrocardiogram of dogs, with particular reference to QT interval

Casoria,

Greet,

Auckburally

et al. 2024

Front. Vet. Sci.

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Cardiac electrical activity is often altered by administration of anesthetic drugs. While the effects of propofol in this regard have previously been described in dogs, to date, there are no reports of the effect of alfaxalone. This study investigated the impact of both propofol and alfaxalone on the ECG of 60 dogs, after premedication with acepromazine and methadone. Heart rate increased significantly in both groups. The PR and QRS intervals were significantly increased following propofol while with alfaxalone the QRS duration was significantly increased and ST segment depression was observed. The QT and JT interval were significantly shorter following induction with alfaxalone, but, when corrected (c) for heart rate, QTc and JTc in both groups were significantly greater following induction. When comparing the magnitude of change between groups, the change in RR interval was greater in the alfaxalone group. The change in both QT and JT intervals were significantly greater following alfaxalone, but when QTc and JTc intervals were compared, there were no significant differences between the two drugs. The similarly increased QTc produced by both drugs may suggest comparable proarrhythmic effects.

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Section: Discussionmentioning

confidence: 99%

Comparison of the effects of propofol and alfaxalone on the electrocardiogram of dogs, with particular reference to QT interval

Casoria,

Greet,

Auckburally

et al. 2024

Front. Vet. Sci.

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“…Es así, que las alteraciones derivan de los trastornos en la generación o conducción de impulsos eléctricos, en el caso de las taquiarritmias se suman además tres mecanismos distintivos: automatismo, actividad desencadenas y reentradas, y en el caso de las bradiarritmias: destacan los fallos de generación del nódulo sinoauricular, obstaculizaciones en la propagación del potencial de acción desde aurículas hacia ventrículos o en el sistema de conducción His -Purkinje (Kim et al, 2023).…”

Section: Introductionunclassified

Ritmo Idioventricular: caso clínico

Espinoza,

Sumba,

Mesa

2024

rgn

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El RIVA se considera la arritmia de mayor prevalencia durante la fase de resolución del infarto agudo de miocardio. la infraestimación del riesgo real sobre ciertas causas adyacentes podría condicionar el desarrollo de complicaciones, siendo determinante la identificación de cambios electrocardiográficas. Determinar los diferentes contextos clínicos que orientan hacia el ritmo idioventricular y su diferenciación de la taquicardia ventricular, así como de otras alteraciones análogas. Con base en criterios de inclusión y exclusión se ejecutó un análisis de caso clínico, junto al análisis de bibliografía de alto impacto. Paciente de 74 años de edad acude a evaluación cardiovascular posterior a IAM, hemodinámicamente estable; se realizó electrocardiograma encontrándose un RIVA más salvas de fibrilación auricular. En conclusión, el manejo especifico se reserva en casos de inestabilidad hemodinámica, asimismo se deberá hacer énfasis en la prevención y control de factores de riesgo cardiovascular.

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