Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H2O2

Khurana, Sandhya; Hollingsworth, Amanda; Piche, Matthew; Venkataraman, Krishnan; Kumar, Aseem; Ross, Gregory M.; Tai, T.C.

doi:10.1155/2014/657512

Cited by 30 publications

(25 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, kinases are not essential for TF3-mediated cardioprotection [70]. In the same cell model and again in comparison to EGCG, methyl gallate, a methyl ester of gallic acid, inhibits apoptosis by decreasing intracellular ROS generation, increasing reduced glutathione levels and maintaining mitochondrial membrane potential [71].…”

Section: Flavanolsmentioning

confidence: 96%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

View full text Add to dashboard Cite

Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies.

show abstract

Section: Flavanolsmentioning

confidence: 96%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

View full text Add to dashboard Cite

show abstract

“…Methyl gallate exhibits a better cardio‐protective effect in comparison to gallic acid as observed in neonatal rat cardiomyocytes challenged with hydrogen peroxide, and improves the mitochondrial functions and increases GSH synthesis . EGCG protects the cardiomyocytes against fluoride‐induced toxicity by improving the functions of several mitochondrial enzymes involved in respiration and metabolism, consequently downregulating the oxidative stress‐induced apoptosis .…”

Section: Cardio‐protective Effects Of Gallatesmentioning

confidence: 99%

Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?

Kosuru

Roy

Das

et al. 2017

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Gallic acid and gallate esters are widely used as dietary supplements or additives with clinical significances. Over the last few decades, a large number of publications have been reported stating the antioxidative, antiapoptotic, cardioprotective, neuroprotective, and anticancer properties of gallic acid and gallates, and mostly demonstrated their antioxidative or prooxidative properties influencing the reactive oxygen species (ROS) signaling networks. However, very little focus has been paid to clinical trials, and this restricted their use as a prescribed preventative supplement. Since mitochondria are the principal organelles responsible for ROS generation, we reviewed the existing literature of mitochondria-specific effects of gallates including ROS production, respiration, mitochondrial biogenesis, apoptosis, and the physico-chemical parameters affecting the outcome of gallate supplementation to various health scenarios such as cardiovascular diseases, neurodegeneration, hepatic ailments, or cancers. The major signaling pathways and the molecules targeted by gallic acid and its derivatives have also been discussed with emphasis on mitochondria as the target site. This review provides a better understanding of the effect of gallic acid and gallate esters on mitochondrial functions and in designing effective preventative measures against the onset of various diseases.

show abstract

“…The results showed that 8 did not demonstrate cytotoxic effects. Khurana et al [77] observed that 8 was able to preserve the viability of neonatal rat cardiomyocytes exposed to H 2 O 2 by decreasing intracellular ROS, maintaining mitochondrial membrane potential, augmenting endogenous glutathione, and reducing apoptosis. Whang et al [75] described that 8 was able to protect HUVEC from oxidative stress.…”

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

View full text Add to dashboard Cite

Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

show abstract

Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H₂O₂

Cited by 30 publications

References 44 publications

Pure Polyphenols Applications for Cardiac Health and Disease

Pure Polyphenols Applications for Cardiac Health and Disease

Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

Contact Info

Product

Resources

About