Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research

Nathan, Jhansi; Kannan, Rajaretinam Rajesh

doi:10.1016/j.heliyon.2020.e05662

Cited by 14 publications

(9 citation statements)

References 181 publications

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“…Marine actinomycin compounds with antitumor potential include streptochlorin, actinofuranones, aureoverticillactam, chalocomycin B, cyanosporasides, komodoquinones, nonactin, resitoflavine, sporolides, tetracenomycin D, thiocoraline, t-muurolol, butenolides, echinosporins, and streptokordin. Important secondary metabolites from marine actinomycetes with antitumor potential include streptopyrrolidine, cyclo-(L-Pro-L-Met), streptochlorin, lynamicins, marizomib, and thiocoraline [ 128 ]. Two examples of novel anticancer metabolites are the compound extracts ULDF4 and ULDF5 derived from Streptomyces strains found at Lagos.…”

Section: Medical Applicationsmentioning

confidence: 99%

Marine Actinomycetes, New Sources of Biotechnological Products

et al. 2021

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The Actinomycetales order is one of great genetic and functional diversity, including diversity in the production of secondary metabolites which have uses in medical, environmental rehabilitation, and industrial applications. Secondary metabolites produced by actinomycete species are an abundant source of antibiotics, antitumor agents, anthelmintics, and antifungals. These actinomycete-derived medicines are in circulation as current treatments, but actinomycetes are also being explored as potential sources of new compounds to combat multidrug resistance in pathogenic bacteria. Actinomycetes as a potential to solve environmental concerns is another area of recent investigation, particularly their utility in the bioremediation of pesticides, toxic metals, radioactive wastes, and biofouling. Other applications include biofuels, detergents, and food preservatives/additives. Exploring other unique properties of actinomycetes will allow for a deeper understanding of this interesting taxonomic group. Combined with genetic engineering, microbial experimental evolution, and other enhancement techniques, it is reasonable to assume that the use of marine actinomycetes will continue to increase. Novel products will begin to be developed for diverse applied research purposes, including zymology and enology. This paper outlines the current knowledge of actinomycete usage in applied research, focusing on marine isolates and providing direction for future research.

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Section: Medical Applicationsmentioning

confidence: 99%

Marine Actinomycetes, New Sources of Biotechnological Products

et al. 2021

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“…Interesting aspects related to the zebrafish model are its high fecundity, fast growth, relatively low maintenance cost, small size (either as embryos or adults), fluorescent receptor production, and optical clarity (allowing the visualization of internal organs and structures) [ 75 , 76 , 77 ]. Zebrafish have been applied in the context of studying specific diseases such as cancer [ 78 , 79 , 80 ], cardiovascular diseases [ 81 ], inflammatory diseases [ 75 , 76 ], and neurological disorders and mental health [ 82 ].…”

Section: Animal Model Context and Further Considerations For Bioactive Marine Alkaloidsmentioning

confidence: 99%

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Munekata¹,

Pateiro²,

Conté-Júnior

et al. 2021

Marine Drugs

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Marine alkaloids comprise a class of compounds with several nitrogenated structures that can be explored as potential natural bioactive compounds. The scientific interest in these compounds has been increasing in the last decades, and many studies have been published elucidating their chemical structure and biological effects in vitro. Following this trend, the number of in vivo studies reporting the health-related properties of marine alkaloids has been increasing and providing more information about the effects in complex organisms. Experiments with animals, especially mice and zebrafish, are revealing the potential health benefits against cancer development, cardiovascular diseases, seizures, Alzheimer’s disease, mental health disorders, inflammatory diseases, osteoporosis, cystic fibrosis, oxidative stress, human parasites, and microbial infections in vivo. Although major efforts are still necessary to increase the knowledge, especially about the translation value of the information obtained from in vivo experiments to clinical trials, marine alkaloids are promising candidates for further experiments in drug development.

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“…Zebrafish has become a popular experimental animal for studies of human cancer [ 32 , 33 ] because (a) zebrafish homologs of human oncogenes and tumor suppressor genes have been identified; (b) the signaling pathways regulating cancer development are conserved [ 34 ]; (c) many zebrafish tumors are similar to those of human cancer in histological examination [ 35 ]; (d) transparent zebrafish embryos are more accessible for observing the dynamic change of tumor cells; and (e) several transgenic zebrafish lines are available for the in vivo study of angiogenesis modulation [ 36 , 37 ]. Therefore, the zebrafish has emerged as a valuable means as an in vivo evaluation platform for screening anti-angiogenesis drugs from chemical compounds [ 38 ], microbial extracts [ 39 ] and Chinese herbal extracts [ 40 ].…”

Section: Screening For Potential Cancer Drugsmentioning

confidence: 99%

Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use

Lin

Tsai

2021

Pharmaceuticals

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The nearly simultaneous convergence of human genetics and advanced molecular technologies has led to an improved understanding of human diseases. At the same time, the demand for drug screening and gene function identification has also increased, albeit time- and labor-intensive. However, bridging the gap between in vitro evidence from cell lines and in vivo evidence, the lower vertebrate zebrafish possesses many advantages over higher vertebrates, such as low maintenance, high fecundity, light-induced spawning, transparent embryos, short generation interval, rapid embryonic development, fully sequenced genome, and some phenotypes similar to human diseases. Such merits have popularized the zebrafish as a model system for biomedical and pharmaceutical studies, including drug screening. Here, we reviewed the various ways in which zebrafish serve as an in vivo platform to perform drug and protein screening in the fields of rare human diseases, social behavior and cancer studies. Since zebrafish mutations faithfully phenocopy many human disorders, many compounds identified from zebrafish screening systems have advanced to early clinical trials, such as those for Adenoid cystic carcinoma, Dravet syndrome and Diamond–Blackfan anemia. We also reviewed and described how zebrafish are used to carry out environmental pollutant detection and assessment of nanoparticle biosafety and QT prolongation.

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Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research

Cited by 14 publications

References 181 publications

Marine Actinomycetes, New Sources of Biotechnological Products

Marine Actinomycetes, New Sources of Biotechnological Products

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use

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