Antiangiogenic effects of melatonin in endothelial cell cultures

Álvarez‐García, Virginia; González, Alicia; Alonso‐González, Carolina; Martínez‐Campa, Carlos; Cos, Samuel

doi:10.1016/j.mvr.2013.02.008

Cited by 73 publications

(88 citation statements)

References 35 publications

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“…Additionally, a significant reduction in VEGFR expression and micro vessel density in murine models followed by melatonin administration, confirming the melatonin anti angiogenesis action [69]. According to the pivotal role of both PKC and NFkB in tumor angiogenesis, it is assumed that interaction of melatonin with either of these molecules contributes in prevention of angiogenesis (Fig.…”

Section: Melatonin and Angiogenesissupporting

confidence: 59%

“…Given to the high expression of MT1/2 and nuclear receptors in human vein endothelial cells, Extensive evidence revealed that melatonin directly inhibits vascular endothelial factor, epidermal growth factor, endothelin-1, and insulin like growth factor-1 in both ER-positive and ER-negative cell lines [68][69][70]. Additionally, a significant reduction in VEGFR expression and micro vessel density in murine models followed by melatonin administration, confirming the melatonin anti angiogenesis action [69].…”

Section: Melatonin and Angiogenesismentioning

confidence: 87%

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Melatonin, an inhibitory agent in breast cancer

et al. 2016

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Section: Melatonin and Angiogenesissupporting

confidence: 59%

Section: Melatonin and Angiogenesismentioning

confidence: 87%

Melatonin, an inhibitory agent in breast cancer

et al. 2016

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“…Melatonin can also induce accumulation of the tumor suppressor factor p53 [101], of the stress-related enzyme JnK [102], and of the pro-apoptotic proteins Bax and caspase-3 [103] in cancer cells. It decreases the activity of the protein kinase, aKt [104], decreases the activity of the angiogenic factor, VeGf [105], and activates the transcription factor nrf-2 [106]. these actions are all expected of an inhibitor of the proteasome [107].…”

Section: Similarities Between Melatonin Action and A Proteasome Inhibmentioning

confidence: 99%

Melatonin and ubiquitin: what’s the connection?

Vriend

Reíter

2014

Cell. Mol. Life Sci.

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“…20 In addition, it has been shown in animal models of breast cancer that melatonin can carry antiangiogenic effects via downregulation of vascular endothelial growth factor expression. 2 Moreover, it can also act synergistically with anticancer drugs, enhancing their effectiveness while reducing their side effects. 12 Despite the fact that evidence for circadian and seasonal effects on cancer progression exist, thus far there are no definitive pathogenetic mechanisms for this observation.…”

Section: Discussionmentioning

confidence: 99%

Seasonal variability in the incidence of carcinomatous meningitis

Koutras¹,

Sakellakis²,

Makatsoris³

et al. 2015

JNS

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OBJECT The aim of the study was to investigate whether there are seasonal differences in the occurrence of carcinomatous meningitis (CM), with a greater prevalence of the disease in months with higher temperatures. METHODS The authors searched the records of all patients with a diagnosis of CM from 1998 until 2013 at the University Hospital of Patras, Greece. The date of hospitalization was extracted for each patient. The cases were divided into 2 categories depending on the time of CM diagnosis. Based on the official data regarding the annual temperature distribution in this region, the authors divided the patients into 2 groups. The first group consisted of cases diagnosed with CM from October 15 to April 15 (cold climate and shorter daytime duration), whereas the second group comprised patients diagnosed between April 15 and October 15 (warm climate and longer daytime duration). RESULTS Overall, 44 confirmed cases of CM were found. The most common type of malignancy associated with the development of CM was breast cancer (27 patients), while the second most common tumor was lung carcinoma (11 patients). The median interval between the time of initial cancer diagnosis and CM was 4.5 years. Thirty-one patients were diagnosed with CM during the period between April 15 and October 15, while the remaining 13 patients developed CM between October 15 and April 15, a significant difference (p = 0.01). CONCLUSIONS Significantly more patients developed CM during the warm season of the year. To the authors' knowledge, this is the first study to provide evidence for the potential seasonal variability in CM incidence. However, these results should be validated prospectively in larger cohorts.

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Antiangiogenic effects of melatonin in endothelial cell cultures

Cited by 73 publications

References 35 publications

Melatonin, an inhibitory agent in breast cancer

Melatonin, an inhibitory agent in breast cancer

Melatonin and ubiquitin: what’s the connection?

Seasonal variability in the incidence of carcinomatous meningitis

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