Antiangiogenic effects of flavonoids and chalcones

Mojžiš, Ján; Varinská, Lenka; Mojžišová, Gabriela; Kostova, Irena; Mirossay, Ladislav

doi:10.1016/j.phrs.2008.02.005

Cited by 210 publications

(145 citation statements)

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“…Chalcones have been recently the subject of great interest due to their interesting pharmacological activities, including antioxidant [1,2], antibacterial [3], antileishmanial [4], anticancer [5], antiangiogenic [6], anti-infective, anti-inflammatory [7], antifungal [8], anti-malarial [9], anti-tumor [10], anti-protozoal [11] and cytotoxic properties [12]. Many pyrazole derivatives are reported to have a broad spectrum of biological activities, such as anti-inflammatory [13], antifungal [14], antiviral [15], cytotoxic [12], A3 adenosine receptor antagonists [16], antioxidant [13], antihypertensive [17], tranquilizing, muscle relaxant, psychoanaleptic, hypnotic, ulcerogenic, antidepressant, antibacterial and analgesic effects [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Hassan

2013

Molecules

139

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A series of 2-pyrazolines 5-9 have been synthesized from α,β-unsaturated ketones 2-4. New 2-pyrazoline derivatives 13-15 bearing benzenesulfonamide moieties were then synthesized by condensing the appropriate chalcones 2-4 with 4-hydrazinyl benzenesulfonamide hydrochloride. Ethyl [1,2,4] Condensation of 6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (1') with compound 24 or 25 afforded the corresponding Schiff's bases 36 and 37, respectively. Reaction of the Schiff's base 37 with benzoyl hydrazine or acetic anhydride afforded benzohydrazide derivative 39 and the cyclized compound 40, respectively. Furthermore, the pyrazole derivatives 42-44 were synthesized by cyclization of hydrazine derivative 25 with the prepared chalcones 2-4. All the newly synthesized compounds have been characterized on the basis of IR and 1 H-NMR spectral data as well as physical data.Antimicrobial activity against the organisms E. coli ATCC8739 and P. aeruginosa ATCC 9027 as examples of Gram-negative bacteria, S. aureus ATCC 6583P as an example of Gram-positive bacteria and C. albicans ATCC 2091 as an example of a yeast-like fungus have been studied using the Nutrient Agar (NA) and Sabouraud Dextrose Agar (SDA) diffusion methods. The best performance was found for the compounds 16, 17, 19 and 20.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Hassan

2013

Molecules

139

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“…Plant polyphenols are known to inhibit angiogenesis and metastasis, through regulation of multiple signaling pathways. Specifically, flavonoids and chalcones regulate the expressions of VEGF, matrix metalloproteinases, EGFR, and inhibit signaling pathways, thereby causing strong anti-angiogenic effects (Mojzis et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Chalcones from Myracrodruon urundeuva are efficacious in guinea pig ovalbumin-induced allergic conjunctivitis

Albuquerque¹,

Leal²,

Bandeira³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of the study was to verify the effects of dimeric chalcones (urundeuvines A, B, and C) from Myracrodruon urundeuva Allemão, Anacardiaceae (a Brazilian anti-inflammatory species), on an allergic conjunctivitis model. Male guinea-pigs were sensitized with two intraperitoneal injections of ovalbumin (10 μg dissolved in 0.5 mL saline and emulsified in 0.5 mL Freund's adjuvant), at days 0 and 7. At day 24, the animals were submitted to an ocular instillation (right eyes) with ovalbumin. At the next day, the animals were treated with chalcones (0.5 mg, three times a day for 7 days), 0.1% fluormetalone acetate (0.05 mg, as the reference drug) or saline. After anesthesia of the animals, enucleations of their corneas and conjunctivas were carried out for morphometric and histological analyses, at days 1, 3 and 7. Their radical scavenging activity and action on myeloperoxidase were also determined. We demonstrated that chalcones from M. urundeuva stem barks presented anti-inflammatory and antioxidant effects, and drastically inhibited the MPO activity, pointing them as candidates for the treatment of allergic conjunctivitis and other inflammatory conditions.

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“…It is presumed that the C-3 position of benzofuran ring was a potential functional site, and the single or double hydroxyl substituted phenyl and mathanone linker on C-3 position were essential for antibacterial activity of benzofuran families. Meanwhile, it was noticed that introducing electron-rich groups into the leading compound is a conventional way of molecular structural modification, and may result better biological performance, for example, the ethylene group in Combrestastatin A-4 derivatives [1,3,4] and Chalcone family analogues [10][11][12][13][14][15][16][17]. To examine the effect of antibacterial activities induced by C-3′ linkers, we achieved a further structural modification on C-2 methoxyphenyl substituted benzofuran skeleton by introducing substituted phenyl groups through α, β-unsaturated ketone linker at the C-3′ position in this paper.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity Study of C-3 α, β-Unsaturated Ketone Linked Benzofuran Derivatives

Liu¹,

Jiang²

2016

Organic Chem Curr Res

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Antiangiogenic effects of flavonoids and chalcones

Cited by 210 publications

References 100 publications

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

Chalcones from Myracrodruon urundeuva are efficacious in guinea pig ovalbumin-induced allergic conjunctivitis

Synthesis and Antibacterial Activity Study of C-3 α, β-Unsaturated Ketone Linked Benzofuran Derivatives

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