Antiangiogenic and Antioxidant Activity of Endophytic Fungus Isolated from Seaweed (Sargassum wightii)

Hulikere, M. Manjunath; Joshi, Chandrashekhar G.; Nivya, T; Danagoudar, Ananda; Raju, Narayanappa Govinda

doi:10.3923/ajb.2016.168.176

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Our results supported that concept as the extracts we obtained from four fungal endophytes showed antioxidant activity to a variable extent. Our findings are consistent with previously published data regarding fungal endophyte P. citrium that exhibited significant antioxidant potential [61].…”

Section: Discussionsupporting

confidence: 93%

Identification and Bioactivities of Two Endophytic Fungi Fusarium fujikuroi and Aspergillus tubingensis from Foliar Parts of Debregeasia salicifolia

et al. 2020

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Endophytic fungi isolated from medicinal plants are important for production of antibiotics. They can produce secondary metabolites with diverse structures and activities. Debregeasia salicifolia is a plant of medicinal importance, and no report exists regarding isolation of endophytic fungi from it. This study was focused to isolate and identify culturable endophytic fungi from foliar parts of D. salicifolia and to determine their bioactivities. Molecular analysis resulted in identification of Fusarium fujikuroi, Aspergillus tubingensis and Rhizopus oryzae based on specific internal transcribed spacer primer (ITS1/ ITS4). Our analysis revealed that all fungal endophytes possess antibacterial activity against Gram-negative and Grampositive bacteria. Remarkably, Rhizopus oryzae at a concentration of 5 mg/mL efficiently restricted the growth of ATCC strain of E. coli in comparison with positive control ciprofloxacin. Rhizopus oryzae and F. fujikuroi at a concentration of 1000 µg/ml exhibited maximum antioxidant activity of 45% and 44%, respectively. They also showed antifungal activity ranging from 60 to 75% against Aspergillus flavus and Aspergillus niger. Our analysis of the fungal extracts through GC-MS indicated the presence of 21 compounds of diverse nature and structure. In conclusion, our study highlighted the potential of D. salicifolia to host a plethora of fungal endophytes that secrete potentially therapeutic bioactive metabolites

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Section: Discussionsupporting

confidence: 93%

Identification and Bioactivities of Two Endophytic Fungi Fusarium fujikuroi and Aspergillus tubingensis from Foliar Parts of Debregeasia salicifolia

et al. 2020

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“…The phylogenetic tree shows a close relationship to T. flavus (Figure 2). Several fungi belonging to the Talraomyces genus have been reported to produce many pharmaceutically important bioactive compounds (He et al, 2014; Hulikere et al, 2016; Kumari et al, 2018; Nicoletti & Trincone, 2016; Sathiyabama & Parthasarathy, 2018; Shin et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Retracted: Isolation and purifications of an ambuic acid derivative compound from marine algal endophytic fungi Talaromyces flavus that induces apoptosis in MDA‐MB‐231 cancer cells

2023

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In recent years, there has been a lot of buzz about the possibilities of marine microflora as a source of new therapeutic drugs. The strong anti‐tumor potency of compounds found in marine resources reflects the ocean's enormous potential as a source of anticancer therapeutics. In this present investigation, an ambuic acid derivative anticancer compound was isolated from Talaromyces flavus, and its cytotoxicity and apoptosis induction potential were analyzed. T. flavus was identified through morphological and molecular analysis. The various organic solvent extracts of T. flavus grown on different growth mediums were evaluated for cytotoxicity on different cancer cell lines. The potent cytotoxicity was shown in the ethyl acetate extract of a fungal culture grown in the M1‐D medium for 21 days. Furthermore, the anticancer compound was identified using preparative thin layer chromatography, followed by its purification in significant proportions using column chromatography. The spectroscopic and chromatographic analysis revealed that the structure of the purified molecules was an ambuic acid derivative. The ambuic acid derivative compound showed potent cytotoxicity on MDA‐MB‐231 (breast cancer cells) with an IC50 value of 26 μM and induced apoptosis in the MDA‐MB‐231 cells in a time‐dependent and reactive oxygen species‐independent manner.

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Biodiversity of endosymbiont fungi associated with a marine sponge Lamellodysidea herbacea and their potential as antioxidant producers

Katoch,

Singh,

Bijarnia

et al. 2024

3 Biotech

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Antiangiogenic and Antioxidant Activity of Endophytic Fungus Isolated from Seaweed (Sargassum wightii)

Cited by 4 publications

References 21 publications

Identification and Bioactivities of Two Endophytic Fungi Fusarium fujikuroi and Aspergillus tubingensis from Foliar Parts of Debregeasia salicifolia

Identification and Bioactivities of Two Endophytic Fungi Fusarium fujikuroi and Aspergillus tubingensis from Foliar Parts of Debregeasia salicifolia

Retracted: Isolation and purifications of an ambuic acid derivative compound from marine algal endophytic fungi Talaromyces flavus that induces apoptosis in MDA‐MB‐231 cancer cells

Biodiversity of endosymbiont fungi associated with a marine sponge Lamellodysidea herbacea and their potential as antioxidant producers

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