Antiangiogenic Activity of Tumor Necrosis Factor-.ALPHA. Production Regulators Derived from Thalidomide.

Specific Nonpeptide Inhibitors of Puromycin-Sensitive Aminopeptidase with a 2,4(1H,3H)-Quinazolinedione Skeleton

“…The extract was washed with water and brine, dried over Na 2 SO 4 , and concentrated under reduced pressure. Purification via silica gel column chromatography (eluent: EtOAc/Hex) gave N-alkylated PAQ-22 (22). …”

Supramolecular dynamics of thalidomide and its derivatives in water‐sediment system

“…Recently, thalidomide is used for the treatment of various diseases such as rheumatoid arthritis, graft-versushost, Behcet's syndrome, cutaneous lupus, cancer, and refractory aphthous ulcerations in patients with AIDS in various countries. [4][5][6][7][8][9] In 1998, thalidomide has been approved specifically for treating erythema nodosum leprosum (ENL) in leprosy (Hansen's Disease) in USA 10 and on investigational basis for the treatment of above-cited disease in some North American countries. [11][12][13][14] It has been observed that thalidomide showed teratogenic effect even after the administration of safe R-(1)-enantiomer because of its rapid conversion into toxic S-(2)-form.…”

Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis

“…Overexpression of COX has been detected in various tumors and its role in carcinogenesis and angiogenesis has been well-documented. [12][13][14][24][25][26] In the past, we suspected that COX is another target molecule of thalidomide (1), because the drug is effective against colon and prostate cancers and possesses anti-angiogenic activity, 27,28) in which COX plays an important role. Indeed, we found that thalidomide (1) itself possesses COX-inhibiting activity.…”