Antiangiogenic Activity of Flavonoids from <i>Melia azedarach</i>

Kumazawa, Shigenori; Kubota, Satomi; Yamamoto, Haruna; Okamura, Nobuyuki; Sugiyamab, Yasumasa; Kobayashia, Hirokazu; Nakanishi, Motoyasu; Ohta, Toshiro

doi:10.1177/1934578x1300801215

Cited by 13 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor angiogenesis can be inhibited by blocking some of these steps. Several papers have been published referring on the modulatory effect of flavonoids on angiogenesis [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ]. Soy isoflavonoids also exhibit anti-angiogenic activities, but the precise mechanism of inhibition remains unclear.…”

Section: Antiangiogenic Effect Of Soy Isoflavonoidsmentioning

confidence: 99%

Soy and Breast Cancer: Focus on Angiogenesis

Varinská

Gál

Mojžišová

et al. 2015

IJMS

144

View full text Add to dashboard Cite

Epidemiological studies have revealed that high consumption of soy products is associated with low incidences of hormone-dependent cancers, including breast and prostate cancer. Soybeans contain large amounts of isoflavones, such as the genistein and daidzain. Previously, it has been demonstrated that genistein, one of the predominant soy isoflavones, can inhibit several steps involved in carcinogenesis. It is suggested that genistein possesses pleiotropic molecular mechanisms of action including inhibition of tyrosine kinases, DNA topoisomerase II, 5α-reductase, galectin-induced G2/M arrest, protein histidine kinase, and cyclin-dependent kinases, modulation of different signaling pathways associated with the growth of cancer cells (e.g., NF-κB, Akt, MAPK), etc. Moreover, genistein is also a potent inhibitor of angiogenesis. Uncontrolled angiogenesis is considered as a key step in cancer growth, invasion, and metastasis. Genistein was found to inhibit angiogenesis through regulation of multiple pathways, such as regulation of VEGF, MMPs, EGFR expressions and NF-κB, PI3-K/Akt, ERK1/2 signaling pathways, thereby causing strong antiangiogenic effects. This review focuses on the antiangiogenic properties of soy isoflavonoids and examines their possible underlying mechanisms.

show abstract

Section: Antiangiogenic Effect Of Soy Isoflavonoidsmentioning

confidence: 99%

Soy and Breast Cancer: Focus on Angiogenesis

Varinská

Gál

Mojžišová

et al. 2015

IJMS

144

View full text Add to dashboard Cite

show abstract

“…The alternative to the conventional methods of using acids to catalyze hydrolysis is to perform the reaction in subcriticalwater [11][12][13]. In recent years, subcritical water has been used as a cheap, environmentally friendly solvent for extraction [14,15], synthetic transformations [16] and the recycling of different organic wastes as, for example, agricultural production processing wastes [15].The hydrothermal reaction has been attracting much attention because of the fascinating physical and chemical characteristics of water near its critical point. In these conditions water exhibits a much lower dielectric constant and a much larger ion product.…”

mentioning

confidence: 99%

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

Lekar

Borisenko

Vetrova

et al. 2015

Natural Product Communications

View full text Add to dashboard Cite

The aim of this work was to study an application of a previously developed expedient acid-free technique for the preparation of glycyrrhetinic acid from ammonium glycyrrhizinate that requires no use of acids and toxic organic solvents. Subcritical water that serves as a reactant and a solvent was used in order to obtain glycyrrhetinic acid in good yields starting from ammonium glycyrrhizinate. It has been shown that variation of only one parameter of the process (temperature) allows alteration to thecomposition of the hydrolysis products. A new method was used for the synthesis of glycyrrhetinic acid (glycyrrhizic acid aglycone) and its monoglycoside. HPLC combined with mass spectrometry and NMR spectroscopy were used to determine the quantitative and qualitative compositions of the obtained products. The method developed for the production of glycyrrhetinic acid in subcritical water is environmentally friendly and faster than conventional hydrolysis methods that use acids and expensive and toxic organic solvents. The proposed technique has a potential for the future development of inexpensive and environmentally friendly technologies for production of new pharmaceutical plant-based substances.

show abstract

“…meridionales , F. oxysporum , F. solani , F. verticillioides , and Sclerotinia sclerotiorum , where vanillin, 4-hydroxy-3-methoxycinnamaldehyde and (±)-pinoresinol were found to be the main compounds [ 99 ]. Additionally, rutin, kaempferol 3- O -robinobioside, and kaempferol 3- O -rutinoside were isolated from water extract of M. azedarach leaves [ 100 ]. Gallic acid and (–) epicatechin were isolated from bark extract [ 101 ].…”

Section: Resultsmentioning

confidence: 99%

Antifungal Activities of Wood and Non-Wood Kraft Handsheets Treated with Melia azedarach Extract Using SEM and HPLC Analyses

et al. 2021

View full text Add to dashboard Cite

The main objective of this work was to evaluate pulp produced by kraft cooking for wood materials (WMT) (Bougainvillea spectabilis, Ficus altissima, and F. elastica) and non-wood materials (NWMT) (Sorghum bicolor and Zea mays stalks) and to study the fungal activity of handsheets treated with Melia azedarach heartwood extract (MAHE) solutions. Through the aforementioned analyses, the ideal cooking conditions were determined for each raw material based on the lignin percentage present. After cooking, pulp showed a decrease in the Kappa number produced from WMT, ranging from 16 to 17. This was in contrast with NWMT, which had Kappa numbers ranging from 31 to 35. A difference in the optical properties of the pulp produced from WMT was also observed (18 to 29%) compared with pulp produced from NWMT (32.66 to 35.35%). As for the evaluation of the mechanical properties, the tensile index of the pulp ranged from 30.5 to 40 N·m/g for WMT and from 44.33 to 47.43 N·m/g for NWMT; the tear index ranged from 1.66 to 2.55 mN·m2/g for WMT and from 4.75 to 5.87 mN·m2/g for NWMT; and the burst index ranged from 2.35 to 2.85 kPa·m2/g for WMT and from 3.92 to 4.76 kPa·m2/g for NWMT. Finally, the double fold number was 3 compared with that of pulp produced from pulp, which showed good values ranging from 36 to 55. In the SEM examination, sheets produced from treated handsheets with extract from MAHE showed no growth of Aspergillus fumigatus over paper discs manufactured from B. speclabilis pulp wood. Pulp paper produced from Z. mays and S. bicolor stalks was treated with 1% MAHE, while pulp paper from F. elastica was treated with 0.50% and 1% MAHE. With the addition of 0.5 or 1% MAHE, Fusarium culmorum showed no increase in growth over the paper manufactured from B. speclabilis, F. altissima, F. elastica and Zea mays pulps with visual inhibition zones found. There was almost no growth of S. solani in paper discs manufactured from pulps treated with 1% MAHE. This is probably due to the phytochemical compounds present in the extract. The HPLC analysis of MAHE identified p-hydroxybenzoic acid, caffeine, rutin, chlorogenic acid, benzoic acid, quinol, and quercetin as the main compounds, and these were present in concentrations of 3966.88, 1032.67, 834.13, 767.81, 660.64, 594.86, and 460.36 mg/Kg extract, respectively. Additionally, due to the importance of making paper from agricultural waste (stalks of S. bicolor and Z. mays), the development of sorghum and corn with high biomass is suggested.

show abstract

Antiangiogenic Activity of Flavonoids from Melia azedarach

Cited by 13 publications

References 10 publications

Soy and Breast Cancer: Focus on Angiogenesis

Soy and Breast Cancer: Focus on Angiogenesis

Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water

Antifungal Activities of Wood and Non-Wood Kraft Handsheets Treated with Melia azedarach Extract Using SEM and HPLC Analyses

Contact Info

Product

Resources

About