Antiangiogenic Activity in Tears: Presence of Pigment-Epithelium-Derived Factor

Abdiu, O.; Setten, Gysbert van

doi:10.1159/000111153

Cited by 9 publications

(5 citation statements)

References 9 publications

(4 reference statements)

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“…1996; Karakousis et al . 2001) and recently has also been detected in the tear fluid of healthy indivduals (Abdiu and Van Setten 2008). Since PEDF inhibits bFGF-induced KNV (Dawson et al .…”

Section: Corneal Neovascularizationmentioning

confidence: 93%

Mediators of ocular angiogenesis

Qazi

Maddula

Ambati

2009

J Genet

153

111

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Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

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Section: Corneal Neovascularizationmentioning

confidence: 93%

Mediators of ocular angiogenesis

Qazi

Maddula

Ambati

2009

J Genet

153

111

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“…PEDF is expressed in most tissues examined, with more prominent levels in the liver, testis, uterus, adipose tissue and skeletal muscle. As a secreted soluble protein, PEDF can also be detected in body fluids such as blood, tears, cerebrospinal fluids and aqueous/vitreous humour [10] , [11] , [12] , [13] , [14] .…”

Section: Pedf Biochemistrymentioning

confidence: 99%

Pigment epithelium-derived factor in lipid metabolic disorders

et al. 2018

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Pigment epithelium-derived factor (PEDF) is a secreted glycoprotein that has anti-angiogenic, anti-proliferative, neurotrophic and immunomodulatory properties. PEDF has recently emerged as a critical metabolic regulatory protein since the discovery of its modulatory activities in the lipolytic pathway by binding to adipose triglyceride lipase (ATGL). Despite being beneficial in maintaining the homeostasis of hepatic lipid accumulation, PEDF has been uncovered an unfavorable role associated with insulin resistance. The molecular events that connect these two apparent distinct observations have been controversial and remained largely unknown. Therefore in this short review, we attempt to summarize the current findings of PEDF regarding its lipid metabolic functions and provide perspectives in identifying PEDF as a potential therapeutic target in lipid disorders.

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“…PEDF is normally found in measurable levels in human tear fluid where its role is linked to maintaining ocular surface health. 66 The concentration of this protein, however, increases in the tears of dry eye patients where it was shown to suppress the expression of inflammatory cytokines such as IL-1β, IL-6, TNF-α, and IL17A. 67 The increase in tear production in the PEDF knockout mice in our study could potentially be due to a compensatory attempt by the LG, in the absence of PEDF, to increase levels of ocular surface support, such as NT3, a trophic factor that showed increased expression in the LG of PEDF knockout mice compared to controls.…”

Section: Discussionmentioning

confidence: 99%

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

Shang

Liu

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Purpose The cornea is richly innervated by the trigeminal ganglion (TG) and its function supported by secretions from the adjacent lacrimal (LG) and meibomian glands (MG). In this study we examined how pigment epithelium–derived factor (PEDF) gene deletion affects the cornea structure and function. Methods We used PEDF hemizygous and homozygous knockout mice to study effects of PEDF deficiency on corneal innervation assessed by beta tubulin staining, mRNA expression of trophic factors, and PEDF receptors by adjacent supporting glands, corneal sensitivity measured using a Cochet-Bonnet esthesiometer, and tear production using phenol red cotton thread wetting. Results Loss of PEDF was accompanied by reduced corneal innervation and sensitivity, increased corneal surface injury and tear production, thinning of the corneal stroma and loss of stromal cells. PEDF mRNA was expressed in the cornea and its supporting tissues, the TG, LG, and MG. Deletion of one or both PEDF alleles resulted in decreased expression of essential trophic support in the TG, LG, and MG including nerve growth factor, brain-derived neurotrophic growth factor, and GDNF with significantly increased levels of NT-3 in the LG and decreased EGF expression in the cornea. Decreased transcription of the putative PEDF receptors, adipose triglyceride lipase, lipoprotein receptor–related protein 6, laminin receptor, PLXDC1, and PLXDC2 was also evident in the TG, LG and MG with the first three showing increased levels in corneas of the Pedf +/ − and Pedf − / − mice compared to wildtype controls. Constitutive inactivation of ERK1/2 and Akt was pronounced in the TG and cornea, although their protein levels were dramatically increased in Pedf − / − mice. Conclusions This study highlights an essential role for PEDF in corneal structure and function and confirms the reported rescue of exogenous PEDF treatment in corneal pathologies. The pleiotropic effects of PEDF deletion on multiple trophic factors, receptors and signaling molecules are strong indications that PEDF is a key coordinator of molecular mechanisms that maintain corneal function and could be exploited in therapeutic options for several ocular surface diseases.

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Antiangiogenic Activity in Tears: Presence of Pigment-Epithelium-Derived Factor

Cited by 9 publications

References 9 publications

Mediators of ocular angiogenesis

Mediators of ocular angiogenesis

Pigment epithelium-derived factor in lipid metabolic disorders

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function

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