Antiangiogene Ansätze in der Therapie des Ovarialkarzinoms

Abstract

Despite promising therapeutic advances in the treatment of patients suffering from ovarian cancer, the prognosis remains poor. A sufficient supply of oxygen and nutrients is crucial for ovarian cancer, which is mainly provided by angiogenesis. The clinical use of new substances which trap proangiogenic substances or inhibit their intracellular transmembrane tyrosine kinase activity will increase as these substances have been shown to exhibit promising anti-tumorous activity. However, these new therapeutic approaches may lead to an increase in side effects such as diarrhea, hypertension, proteinuria, intestinal perforation and others, which are still relatively unknown, and these side effects will require adequate consecutive treatment.