Antiandrogenic and Estrogenic Compounds: Effect on Development and Function of Male Reproductive System

Hejmej, Anna; Kotula–Balak, Małgorzata; Bilińska, Barbara

doi:10.5772/28538

Cited by 11 publications

(10 citation statements)

References 239 publications

(171 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2-hydroxyflutamide, ketoconazole) as well as environmental contaminants: pesticides (e.g. vinclozolin, linuron) or synthetic androgens such as testosterone propionate or boldione, which are widely used anabolic steroids [82]. During our previous experiments concerning the involvement of androgen in ovarian follicular development and atresia, we generated an in vitro toxicological model for studying androgen deficiency.…”

Section: Antiandrogenic and Androgenic Edc Action Within The Ovarymentioning

confidence: 99%

The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer

Duda¹,

Wartalski²,

Tabarowski³

et al. 2017

Theriogenology

View full text Add to dashboard Cite

Androgens, steroid hormones produced by follicular cells, play a crucial role in the regulation of ovarian function. They affect folliculogenesis directly through androgen receptors (ARs) or indirectly through aromatization to estrogens. Androgens are thought to be primarily involved in preantral follicle growth and prevention of follicular atresia. It also seems possible that they are involved in the activation of primordial follicles. According to the World Health Organization, endocrine-disrupting chemicals (EDCs) are substances that alter hormonal signaling. EDCs comprise a wide variety of synthetic or natural chemicals arising from anthropogenic, industrial, agricultural, and domestic sources. EDCs interfere with natural regulation of the endocrine system by either mimicking or blocking the function of endogenous hormones as well as acting directly on gene expression or through epigenetic modifications. Disruptions in ovarian processes caused by EDCs may originate adverse outcomes such as anovulation, infertility, or premature ovarian failure. In this chapter, we aim to point out a possible involvement of androgen excess or deficiency in the regulation of ovarian function. We will summarize the effects of EDCs expressing antiandrogenic or androgenic activity on female physiology. Continuous exposition to even small concentration of such compounds can initiate oncogenesis within the ovary.

show abstract

Section: Antiandrogenic and Androgenic Edc Action Within The Ovarymentioning

confidence: 99%

The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer

Duda¹,

Wartalski²,

Tabarowski³

et al. 2017

Theriogenology

View full text Add to dashboard Cite

show abstract

“…First of all, BPA exhibits weak estrogenic and antiandrogenic proprieties. It binds to both estrogen receptors (ERs), ERα and ERβ ( 1 , 10 ), and at high concentrations, BPA binds to the androgen receptor (AR) on which it acts as an antagonist ( 16 ). In addition to binding to the ARs, it disturbs the hypothalamic–pituitary–testicular axis and modulates gene expression and the enzymatic activity of testicular steroidogenesis ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Bisphenols on Testicular Steroidogenesis

et al. 2020

View full text Add to dashboard Cite

Over the last decades, the adverse effects of human exposure to the so-called “endocrine disruptors” have been a matter of scientific debate and public attention. Bisphenols are synthetic chemicals, widely used in the manufacture of hard plastic products. Bisphenol A (BPA) is one of the best-known environmental toxicants proven to alter the reproductive function in men and to cause other health problems. Consumer concern resulted in “BPA free” products and in the development of bisphenol analogs (BPA-A) to replace BPA in many applications. However, these other bisphenol derivatives seem to have effects similar to those of BPA. Although a number of reviews have summarized the effects of BPA on human reproduction, the purpose of this article is to review the effects of bisphenols on testicular steroidogenesis and to explore their mechanisms of action. Testicular steroidogenesis is a fine-regulated process, and its main product, testosterone (T), has a crucial role in fetal development and maturation and in adulthood for the maintenance of secondary sexual function and spermatogenesis. Contradictory outcomes of both human and animal studies on the effects of BPA on steroid hormone levels may be related to various factors that include study design, dosage of BPA used in in vitro studies, timing and route of exposure, and other confounding factors. We described the main possible molecular target of bisphenols on this complex pathway. We report that Leydig cells (LCs), the steroidogenic testicular component, are highly sensitive to BPA and several mechanisms concur to the functional impairment of these cells.

show abstract

“…A variety of EDCs have been observed in the treated drinking water supply throughout the world, particularly in tap water from as low as 0.2 ng/L to as high as 5510.0 ng/L, while a maximum concentration (28,000.0 ng/L) was observed in drinking water from the wells in India (Wee and Aris 2019). Some food packaging materials such as plastics contain EDCs (Benjamin et al 2017;Hejmej et al 2011). Children are more vulnerable because some of the toys and feeding bottles contain EDCs (Wong and Durrani 2017).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Farounbi

Ngqwala

2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

Endocrine-disrupting compounds are attracting attention worldwide because of their effects on living things in the environment. Ten endocrine disrupting compounds: 4-nonylphenol, 2,4-dichlorophenol, estrone, 17β-estradiol, bisphenol A, 4-tertoctylphenol, triclosan, atrazine, imidazole and 1,2,4-triazole were investigated in four rivers and wastewater treatment plants in this study. Rivers were sampled at upstream, midstream and downstream reaches, while the influent and effluent samples of wastewater were collected from treatment plants near the receiving rivers. Sample waters were freeze-dried followed by extraction of the organic content and purification by solid-phase extraction. Concentrations of the compounds in the samples were determined with ultra-high performance liquid chromatography-tandem mass spectrometry. The instrument was operated in the positive electrospray ionization (ESI) mode. The results showed that these compounds are present in the samples with nonylphenol > dichlorophenol > bisphenol A > triclosan > octylphenol > imidazole > atrazine > triazole > estrone > estradiol. Nonylphenol has its highest concentration of 6.72 μg/L in King Williams Town wastewater influent and 2.55 μg/L in midstream Bloukrans River. Dichlorophenol has its highest concentration in Alice wastewater influent with 2.20 μg/L, while it was 0.737 μg/L in midstream Bloukrans River. Uitenhage wastewater effluent has bisphenol A concentration of 1.684 μg/L while it was 0.477 μg/L in the downstream samples of the Bloukrans River. Generally, the upstream samples of the rivers had lesser concentrations of the compounds. The wastewater treatment plants were not able to achieve total removal of the compounds in the wastewater while runoffs and wastes dump from the cities contributed to the concentrations of the compounds in the rivers.

show abstract

Antiandrogenic and Estrogenic Compounds: Effect on Development and Function of Male Reproductive System

Cited by 11 publications

References 239 publications

The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer

The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer

Effects of Bisphenols on Testicular Steroidogenesis

Occurrence of selected endocrine disrupting compounds in the eastern cape province of South Africa

Contact Info

Product

Resources

About