Antiamoebic drugs for treating amoebic colitis

Gonzales, Maria Liza M; Dans, Leonila F.; Martinez, Elizabeth G

doi:10.1002/14651858.cd006085.pub2

Cited by 58 publications

(36 citation statements)

References 118 publications

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“…In this study, our findings demonstrated the efficacy of 10 day course of Metronidazole in resolving diarrhea for which the causative organism was identified by microscopic examination of stool samples to be Entamoeba histolytica, so Metronidazole which is an amoebicidal and bactericidal agent with low toxicity is the drug of choice to treat acute amoebic colitis and it is found that Metronidazole is effective against amoebic liver abscess (McAuley et al, 1992;Gonzales et al, 2009), although surgical aspiration may be needed sometime, but it is demonstrated that use of another agent in addition to Metronidazole that is active against cysts is needed in some cases like Septrin which has efficacy rate of more than 90% in eradication of the amoebic cysts (McAuley et al, 1992), but the use of this agent is limited because of its adverse effects (Gastrointestinal and neurological side effects which were produced in 9% of the patients given the treatment after 14 years experience with the use of Septrin. The clinical syndrome of non-dysenteric intestinal amoebiasis or chronic amoebiasis has been a controversial entity for sometime.…”

Section: Discussionmentioning

confidence: 55%

Relationship Between Metronidazole and Co-Trimoxazole on Eradication of Entamoeba Histolytica

Aladwan¹,

Abu-Rumman²,

Jarrar

et al. 2012

American Journal of Microbiology

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To present the efficacy and safety of Metronidazole and co-trimoxazole in the treatment of diarrhea caused by Entamoeba histolytica, cyst and trophozyed in patients presented to the emergency department and emergency pediatric clinic in Queen Alia Hospital (Jordan). A strategy for diagnosis Entamoeba histolytica was evaluated by studying 181 patients aged 2-50 years. Between the 1st of May 2009 and the beginning of May 2010, 181 patients with intestinal amoebiasis were recruited for this study from the Emergency Department and emergency Pediatric Clinic at Queen Alia Military Hospital. After doing stool analysis for every patient, Metronidazole 500 mg three times was given to the adult group and 40 mg kg -1 day in three divided doses for the pediatric group for 10 days and two tablets twice daily for adults and 5 mL twice daily for children for ten days of co-trimaxazole, with follow up stool analysis after one week of treatment. Out of 181 patients (81) patients were adult's age (14-50 years) and (100 patients) were children aged (2-14 years). About 5.5% of the patient showed the amoebic trophozoite in their stool while the remaining showed only the amoebic cysts. Over all metronidazole and co-trimoxazole produced a clinical response rate of 95% in both adults and children group after 10 days course of Metronidazole. Our findings demonstrated the efficacy of 10 day of course Metronidazole and co-trimoxazole in eradication intestinal amoebiasis for which the causative organism is identified by simple stool examination.

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Section: Discussionmentioning

confidence: 55%

Relationship Between Metronidazole and Co-Trimoxazole on Eradication of Entamoeba Histolytica

Aladwan¹,

Abu-Rumman²,

Jarrar

et al. 2012

American Journal of Microbiology

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“…The present recommendations are to combine this drug with some luminal amoebicidal like paromycin or diloxanide furoate. Though metronidazole is effective in treating the amoebiasis but it resulted in failure due to development of resistance by E. histolytica against it (Orozco, 2002;Gonzales, 2009).…”

Section: Discussionmentioning

confidence: 99%

Comparison of allopathic and herbal medicine for the treatment of Entamoeba histolytica: A double blind clinical trial

Siddiqui¹,

Usmanghani²

2015

J. Med. Plants Res.

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This parallel, randomized, double blind clinical trial was designed to compare allopathic drugs [a combination of metronidazole + diloxanide furoate (MDF)] with Endemali (herbal product) for therapeutic cure rate and side effects in order to find out the most suitable drug for this killer disease. This double blind randomized clinical trial was conducted in two areas of Karachi, Pakistan after approval from ethical committee of Hamdard University. All those confirmed for Entamoeba histolytica were included in the study. One hundred and seventy one patients selected for the study were randomly allocated to two arms of 86 and 85 for allopathic and herbal treatment, respectively. However 78 in allopathic and 75 in herbal group completed the study. Main outcome variable was treatment success or failure. Secondary outcome measures included side effects and association with age and sex. No significant difference was observed in the socio economic and demographic variables at the baseline. No significant difference was found between the cure rate of MDF and Endemali; hence both drugs were equally effective in treating amoebiasis. Significant differences were reported for the side effects observed among the two groups and the price. The failure rate for the two drugs was 28.7%. It is concluded that both Endemali and MDF are equally effective in treating amoebiasis. However, Endemali has fewer side effects than MDF. New drugs need to be researched for the treatment of E. histolytica because of high failure rate of the two drugs against this killer organism.

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“…Tinidazole and ornidazole are further alternatives to metronidazole in the treatment of amoebiasis, giardiasis and trichomoniasis [79][80][81][82]. Tinidazole is administered in a 2 g dose taken daily over 3 days for intestinal amoebiasis in adults, and in children at 50 M a n u s c r i p t A c c e p t e d M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t A c c e p t e d M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t…”

Section: Amoebiasis Giardiasis and Trichomoniasismentioning

confidence: 99%