Antiamoebic Activity of Iridoids from <i>Morinda morindoides</i> Leaves

Cimanga, K.; Kambu, K.; Tona, L.; Hermans, Nina; Apers, Sandra; Totté, J.; Pieters, Luc; Vlietinck, A. J.

doi:10.1055/s-2006-931581

Cited by 17 publications

(6 citation statements)

References 12 publications

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“…Flavonoids from M. morindoides have anti-complementary [17], anti-oxidative [18], anti-amoebic [19], and antispasmodic activities [20] in vitro. Iridoid glucosides from this plant have anti-malarial [21] and antiamoebic activities [22].…”

Section: Introductionmentioning

confidence: 99%

Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

et al. 2021

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Two phenylpropanoid conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided fractionation using an anti-malarial activity assay. The known related iridoids molucidin (3) and prismatomerin (4), two lignans, abscisic acid, two megastigmanes, and two avonol glycosides were also identi ed. The structures of isolated compounds were elucidated using spectroscopic analysis. The isolated compounds were evaluated for anti-malarial activity against the chloroquine/me oquine-sensitive strains of Plasmodium falciparum together with cytotoxicity against adult mouse brain cells. Potent anti-malarial activity of and 4 (IC 50 of 0.96 and 0.80 µM, respectively) was shown, while new iridoids 1 and 2 and pinoresinol (5) displayed moderate activity (IC 50 of 40.9, 20.6, and 24.2 µM, respectively). These results indicate that 1-5 may be promising lead compounds for anti-malarial drugs and that extracts of M. morindoides leaves could be effective remedies for malaria infection.

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Section: Introductionmentioning

confidence: 99%

Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

et al. 2021

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“…While the literature data highlight on the presence of saponins (Cimanga et al, 2010), terpenes, steroids, tannins, and anthraquinones (Kiazolu et al, 2016) and extensive phytochemical studies on this Morinda species have resulted in the isolation of some compounds such as flavonoids (Cimanga et al, 2006, 2008), iridoids (Cimanga et al, 2003, 2006a; Tamura et al, 2010), and anthraquinones (Cimanga et al, 2008). Several studies have highlighted on the biological activities of M. morindoides related to its traditional use, which include antimalarial (Cimanga et al, 2008; Onabanjo, 1983; Tona et al, 2001), antioxidant (Cimanga et al, 1999), antidiarrheal (Meite et al, 2009), antiamebic (Cimanga et al, 2006b), and anticomplementary activity (Cimanga et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Novel insights into the fruit and seed extracts ofMorinda morindoides(Baker) Milne‐Redh: HPLC‐ESI‐Q‐TOF‐MS profiling, antioxidant, and enzyme inhibitory propensities

et al. 2020

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In this study, we attempted for the first time to determine the phytochemical compositions and biopharmaceutical properties of the methanolic and aqueous extracts of Morinda morindoides fruits and seeds. Antioxidant propensities of the extracts were determined via free radical‐scavenging, phosphomolybdenum, metal chelating, and reducing power assays. Inhibitory activities against cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)), tyrosinase, α‐amylase, and α‐glucosidase were assessed. Moreover, the total phenolic and flavonoid contents were determined. High Performance Liquid Chromatography coupled to Electrospray Ionization Quadrupole Time‐of‐Flight Mass Spectrometry (HPLC‐ESI‐Q‐TOF‐MS) analysis was performed to establish the chemical profile of the investigated extracts. The tested extracts showed remarkable antioxidant abilities with aqueous fruit extract being most potent in all assays, except for ferrous ion chelating assay. Overall, the methanolic extracts were potent inhibitors of the tested enzymes. In conclusion, M. morindoides may be endorsed as promising sources of bioactive compounds and used for designing functional foods. Practical applications In recent years, new compounds from plant sources have attracted great interest to design functional foods. Thus, we aimed to detect biological and chemical properties of Morinda morindoides fruits and seeds, a widely used as food with medicinal properties in Africa. Based on our findings, fruits extracts exhibited stronger activity when compared to seed extracts. Also, chemical identification was performed for each extracts. The presented findings could provide valuable information into the pool of scientific knowledge and may be basis for the design of novel functional applications from M. morindoides.

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“…In the context of this study, observations with extracts from Geranium mexicanum [4] and Morinda morinoides [8] in E. histolytica are of interest as they yielded IC50 values of 1.9 µg/ml and 1.7 µg/ml, respectively, i.e. moderately higher as compared to those reported in this study for extracts from Stemona and Aglaia species.…”

Section: Discussionmentioning

confidence: 53%

“…However, there was lately increased interest in this field [4][5][6][7][8][9][10]. The study was conducted with the following objectives:…”

Section: Introductionmentioning

confidence: 99%

Development of a pharmacodynamic screening model with Entamoeba histolytica

Tasanor

Brem

Leitsch

et al. 2007

Wien Klin Wochenschr

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Human amoebiasis caused by Entamoeba histolytica is widely distributed in the tropics and subtropics, but also occurring in neighbouring parts of the temperate zones. Invasive amoebiasis causes dysentery and, by haematogenous spread, also extra-intestinal hepatic, pulmonary or cerebral abscesses, not rarely fatal conditions. The available anti-amoebic drugs have shortcomings regarding tolerability and efficacy. To facilitate the screening of candidate material, an in vitro system has been developed that permits the determination of specific anti-amoebic activity. PYE medium, supplemented with bovine serum, proved to be suitable for the maintenance of the stock cultures of Entamoeba histolytica strain HM1:1MSS. For sensitivity testing, Waymouth medium and cultivation under aerobic conditions were most reliable. After adapting the system to the use of 96-well (8 x 12) tissue culture plates, sensitivity tests were carried out with metronidazole, dehydroemetine and dihydroartemisinin as active control drugs, and seven extracts from Stemona tuberosa, Aglaia edulis, Aglaia elaeagnoidea and Aglaia odorata. Stem bark extract from Aglaia elaeagnoidea was the most active material with an IC(99) of 496 ng/ml and a slope S of 1.1325, followed by leaf extract from Stemona tuberosa with an IC(99) of 638 ng/ml and a slope S of 1.5648. All seven extracts showed full activity at concentrations <4000 ng/ml and qualified for further investigation.

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Antiamoebic Activity of Iridoids from Morinda morindoides Leaves

Cited by 17 publications

References 12 publications

Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides

Novel insights into the fruit and seed extracts ofMorinda morindoides(Baker) Milne‐Redh: HPLC‐ESI‐Q‐TOF‐MS profiling, antioxidant, and enzyme inhibitory propensities

Development of a pharmacodynamic screening model with Entamoeba histolytica

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