2017
DOI: 10.3390/toxins9090285
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Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I)

Abstract: Neuropathic pain in a chronic post-ischaemic pain (CPIP) model mimics the symptoms of complex regional pain syndrome type I (CRPS I). The administration of bee venom (BV) has been utilized in Eastern medicine to treat chronic inflammatory diseases accompanying pain. However, the analgesic effect of BV in a CPIP model remains unknown. The application of a tight-fitting O-ring around the left ankle for a period of 3 h generated CPIP in C57/Bl6 male adult mice. BV (1 mg/kg; 1, 2, and 3 times) was administered int… Show more

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Cited by 9 publications
(9 citation statements)
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“…To begin, we established a rat model of CRPS according to methods described before [ 18 , 21 ]. The hind paw of the CPIP rats showed clear evidence of hypoxia, becoming cold and cyanotic when the O-ring was placed ( Figure 1 A,B).…”
Section: Resultsmentioning
confidence: 99%
“…To begin, we established a rat model of CRPS according to methods described before [ 18 , 21 ]. The hind paw of the CPIP rats showed clear evidence of hypoxia, becoming cold and cyanotic when the O-ring was placed ( Figure 1 A,B).…”
Section: Resultsmentioning
confidence: 99%
“…lead to the measurement of one dominant conductance per cell. The first and second observations have implications for therapeutic targeting of ion channels to suppress unwanted responses to venom and for the informed design of therapeutic Hymenoptera-based therapies [44][45][46][47][48][49][50] for cancer, pain, and inflammation. The third of these key findings is intriguing and suggests a novel mechanism by which cellular decisions to activate one ion channel rather than another, despite coexpression, for future investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Complex regional pain syndrome (CRPS) is a chronic, painful condition that can affect any part of the body, but it commonly affects the limbs [ 1 , 2 , 3 , 4 , 5 , 6 ] CRPS involves vasomotor changes such as changes in color and temperature of the skin, edema, increased sensitivity to touch, and a limited range of movement [ 1 , 2 ]. CRPS occurs due to any damage or injury to the central or peripheral nervous system and can also develop after direct trauma to the limbs [ 1 , 2 ].…”
Section: Introductionmentioning
confidence: 99%