Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I)

Lee, Sung Hyun; Lee, Jae Min; Kim, Yun Hong; Choi, Jung Hyun; Jeon, Seung Hwan; Kim, Dong Kyu; Jeong, Hyeon Do; Lee, You Jung; Park, Hue Jung

doi:10.3390/toxins9090285

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…To begin, we established a rat model of CRPS according to methods described before [ 18 , 21 ]. The hind paw of the CPIP rats showed clear evidence of hypoxia, becoming cold and cyanotic when the O-ring was placed ( Figure 1 A,B).…”

Section: Resultsmentioning

confidence: 99%

Possible Therapeutic Options for Complex Regional Pain Syndrome

2021

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Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma. Research on the pharmacological treatment of CRPS, however, has not been well investigated. In this study, we compared the pain relief effects of different drugs (URB597, pyrrolidine dithiocarbamate, and hydralazine) in a rat model of chronic post-ischemic pain-induced CRPS. After drug injection, CRPS-induced mechanical allodynia was significantly recovered. After three repetitive drug injections, mechanical sensitivity generally improved as hyper-nociception subsided. Reduced Nav1.7 expression at dorsal root ganglions (DRGs) was observed in the drug treatment groups. Neural imaging analysis revealed decreased neural activity for each drug treatment, compared to vehicle. In addition, treatments significantly reduced IL-1β, IL-6, and TNFα expression in DRGs. These results indicated that drugs could reduce the expression of inflammatory factors and alleviate the symptoms of chronic post-ischemic pain-induced CRPS.

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Section: Resultsmentioning

confidence: 99%

Possible Therapeutic Options for Complex Regional Pain Syndrome

2021

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“…lead to the measurement of one dominant conductance per cell. The first and second observations have implications for therapeutic targeting of ion channels to suppress unwanted responses to venom and for the informed design of therapeutic Hymenoptera-based therapies [44][45][46][47][48][49][50] for cancer, pain, and inflammation. The third of these key findings is intriguing and suggests a novel mechanism by which cellular decisions to activate one ion channel rather than another, despite coexpression, for future investigation.…”

Section: Discussionmentioning

confidence: 99%

In vitroexposure toHymenopteravenom and constituents activates discrete ionotropic pathways in mast cells

et al. 2019

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Calcium entry is central to the functional processes in mast cells and basophils that contribute to the induction and maintenance of inflammatory responses. Mast cells and basophils express an array of calcium channels, which mediate responses to diverse stimuli triggered by small bioactive molecules, physicochemical stimuli and immunological inputs including antigens and direct immune cell interactions. These cells are also highly responsive to certain venoms (such as Hymenoptera envenomations), which cause histamine secretion, cytokine release and an array of pro-inflammatory functional responses. There are gaps in our understanding of the coupling of venom exposure to specific signaling pathways such as activation of calcium channels. In the present study, we performed a current survey of a model mast cell line selected for its pleiotropic responsiveness to multiple pro-inflammatory inputs. As a heterogenous stimulus, Hymenoptera venom activates multiple classes of conductance at the population level but tend to lead to the measurement of only one type of conductance per cell, despite the cell co-expressing multiple channel types. The data show that I CRAC , I ARC, and TRPV-like currents are present in the model mast cell populations and respond to venom exposure. We further assessed individual venom components, specifically secretagogues and arachidonic acid, and identified the conductances associated with these stimuli in mast cells. Single-cell calcium assays and immunofluorescence analysis show that there is heterogeneity of channel expression across the cell population, but this heterogeneity does not explain the apparent selectivity for specific channels in response to exposure to venom as a composite stimulus.

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“…Complex regional pain syndrome (CRPS) is a chronic, painful condition that can affect any part of the body, but it commonly affects the limbs [ 1 , 2 , 3 , 4 , 5 , 6 ] CRPS involves vasomotor changes such as changes in color and temperature of the skin, edema, increased sensitivity to touch, and a limited range of movement [ 1 , 2 ]. CRPS occurs due to any damage or injury to the central or peripheral nervous system and can also develop after direct trauma to the limbs [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of rTMS in the management of pain associated with CRPS

Lee

Kwak

Park

2020

Translational Neuroscience

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BackgroundTherapeutic management of pain in patients with complex regional pain syndrome (CRPS) is challenging. Repetitive transcranial magnetic stimulation (rTMS) has analgesic effects on several types of pain. However, its effect on CRPS has not been elucidated clearly. Therefore, we conducted a meta-analysis of the available clinical studies on rTMS treatment in patients with CRPS.Materials and methodsA comprehensive literature search was conducted using the PubMed, EMBASE, Cochrane Library, and SCOPUS databases. We included studies published up to February 09, 2020, that fulfilled our inclusion and exclusion criteria. Data regarding measurement of pain using the visual analog scale before and after rTMS treatment were collected to perform the meta-analysis. The meta-analysis was performed using Comprehensive Meta-analysis Version 2.ResultsA total of three studies (one randomized controlled trial and two prospective observational studies) involving 41 patients were included in this meta-analysis. No significant reduction in pain was observed immediately after one rTMS treatment session or immediately after the entire schedule of rTMS treatment sessions (5 or 10 sessions; P > 0.05). However, pain significantly reduced 1 week after the entire schedule of rTMS sessions (P < 0.001).ConclusionrTMS appears to have a functional analgesic effect in patients with CRPS.

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Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I)

Cited by 9 publications

References 32 publications

Possible Therapeutic Options for Complex Regional Pain Syndrome

Possible Therapeutic Options for Complex Regional Pain Syndrome

In vitroexposure toHymenopteravenom and constituents activates discrete ionotropic pathways in mast cells

The effect of rTMS in the management of pain associated with CRPS

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