“…KARs are tetrameric assemblies of GluK1–5 subunits (Collingridge et al, 2009) and have been implicated in various functions in the central nervous system (Jane et al, 2009; Lerma, 2006; Pinheiro and Mulle, 2006). In addition, KARs and in particular those containing the GluK1 subunit have been implicated in a number of neurological conditions, such as chronic pain (Jones et al, 2006; Simmons et al, 1998), migraine (Weiss et al, 2006), epilepsy (Smolders et al, 2002) and neurodegeneration (O’Neill et al, 2000) as well as in psychiatric conditions, such as schizophrenia (Beneyto et al, 2007) and anxiety (Alt et al, 2007). …”