Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats

Anandan, R.; Ganesan, B.; Obulesu, T; Mathew, Suseela; Asha, K.K.; Lakshmanan, P.T.; Zynudheen, A.A.

doi:10.1007/s12192-012-0354-2

Cited by 41 publications

(20 citation statements)

References 31 publications

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“…Apart from the enzymatic antioxidant system, the nonenzymatic antioxidant system also plays an important role in the defense aspect of oxidative damage (Anandan et al, 2013). GSH, as a typical non-enzymatic antioxidant, is capable of maintaining the redox equilibrium in hRBCs (van't Erve et al, 2014).…”

Section: Effects Of Pbde-209 On Antioxidant Defense Capacity Of Hrbcsmentioning

confidence: 99%

In vitro cytotoxicity of decabrominated diphenyl ether (PBDE-209) to human red blood cells (hRBCs)

et al. 2017

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Section: Effects Of Pbde-209 On Antioxidant Defense Capacity Of Hrbcsmentioning

confidence: 99%

In vitro cytotoxicity of decabrominated diphenyl ether (PBDE-209) to human red blood cells (hRBCs)

et al. 2017

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“…Chitosan, a polysaccharide found in shellfish, krill, fungi, and insects, has membrane stabilizing properties (Filipović-Grcić et al 2001) and helps to upregulate Hsp70 expression (Khodagholi et al 2010). Chitosan was reported to be neuroprotective by suppressing Aβ formation (Khodagholi et al 2010), it can reduce age-related dyslipidemic abnormalities and oxidative stress in aged rats (Anandan et al 2013), and has anti-ulcerogenic effect against HCl-ethanol induced ulcer (Anandan et al 2004). Geranylgeranylacetone (GGA) is an antiulcer drug which protects the cells of the gastric mucosa against several forms of stress.…”

Section: Possible Mechanism Of Hsp Protection and Potential Therapeutmentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.

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“…Liu et al (2011) showed that dietary supplementation with suitable dose of CHI could improve the antioxidative function of broilers. Anandan et al (2013) suggested that CHI could be an effective therapeutic agent in the treatment of age-associated disorders in rats where oxidative stress was the major causative factor.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

Li¹,

Na²,

Yu³

et al. 2015

CZECH J ANIM SCI

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The present experiment was conducted to study the effects of chitosan (CHI) on immune and antioxidative function in beef cattle. A total of 24 fattening Simmental cattle with similar body weight and age were divided randomly into three dietary groups, and the three diets contained 0, 500, and 1000 mg/kg CHI, respectively. The feeding trial lasted for 84 days. It was found that: (1) the addition of CHI in diets improved (P < 0.05) the levels of IgA and interleukin-1, and decreased (P < 0.1) the levels of soluble cluster of differentiation 4 receptor in serum at middle stage except that IgA remained unchanged in 1000 mg/kg CHI group. The levels of IgM and IgA tended to be increased (P < 0.1) by dietary CHI at later stage of the experiment; (2) the addition of 500 mg/kg CHI in diets increased (P < 0.1) total superoxide dismutase activity and decreased (P < 0.05) malondialdehyde content in serum at early and later stages, respectively. In conclusion, these results indicated that addition of 500 mg/kg CHI affected humoral and cellular immune responses, and improved the antioxidative function of beef cattle.

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Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats

Cited by 41 publications

References 31 publications

In vitro cytotoxicity of decabrominated diphenyl ether (PBDE-209) to human red blood cells (hRBCs)

In vitro cytotoxicity of decabrominated diphenyl ether (PBDE-209) to human red blood cells (hRBCs)

Alcohol stress, membranes, and chaperones

Effects of dietary supplementation of chitosan on immune and antioxidative function in beef cattle

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