Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans

Hou, Zhiying; Zhu, Deqi; Gao, Xinchang; Zhao, Li; Yang, Hui; Wang, Qiong; Zhao, Yufen; Wang, Ning

doi:10.1016/j.jff.2023.105829

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…However, unregulated overproduction of ROS can damage DNA, proteins, lipids, and even cells. In summary, there is a correlation between the antioxidant activity of plants and their effect on skin related problems such as wounds, aging and this effect has been well reported [28,29] …”

Section: Resultsmentioning

confidence: 83%

“…In summary, there is a correlation between the antioxidant activity of plants and their effect on skin related problems such as wounds, aging and this effect has been well reported. [28,29] In this present study, the antioxidant activity was evaluated by using the CUPRAC, FRAP, TOAC, DPPH radical scavenging activities in extract, novel formulation and each of the fractions. Results were given in Table 3.…”

Section: In Vitro Antioxidant Testsmentioning

confidence: 99%

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In vitro Evaluation of Skin Related Enzyme Inhibitory Effect and Emulgel Formulation Development Studies of Onobrychis Argyrea subsp. Argyrea with Phytochemical Analysis

Şentürk,

Barak,

Çağlar

et al. 2024

Chemistry & Biodiversity

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Species of Onobrychis have been used to treat skin disorders such as wounds and cuts in folk medicine and Onobrychis argyrea subsp. argyrea (OA) commonly known as ‘silvery sainfoin’, is a member of this genus. In this study, it was aimed to investigate the skin‐related biological activities and phytochemical characterization of OA. Moreover, an emulgel formulation was developed from the main methanolic extract of the plant (OAM). Initially, to identifiy of the active fractions, aerial parts of the plant material was extracted with methanol and fractionated by n‐hexane, chloroform, ethyl acetate and n‐butanol, respectively. Antioxidant activity was determined by CUPRAC, TOAC, FRAP and DPPH assays. Thereafter, the inhibition potential of OAM, novel formulation and all fractions was measured against elastase, collagenase, tyrosinase and hyaluronidase enzymes. OAM was analyzed and characterized by LC/MS‐MS. The major bioactive flavonoids which are rutin and isoquercetin were measured and compared as qualitative and quantitative via high performance thin layer chromatography (HPTLC) analysis in OAM and fractions. The results showed that extracts of OA can be a potential cosmeceutical agent for skin related problems.

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Section: Resultsmentioning

confidence: 83%

Section: In Vitro Antioxidant Testsmentioning

confidence: 99%

In vitro Evaluation of Skin Related Enzyme Inhibitory Effect and Emulgel Formulation Development Studies of Onobrychis Argyrea subsp. Argyrea with Phytochemical Analysis

Şentürk,

Barak,

Çağlar

et al. 2024

Chemistry & Biodiversity

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show abstract

“…It In studies utilizing C. elegans as the model organism, various concentrations of jujube water extracts were found to enhance the antioxidant activity of C. elegans. For instance, jujube water extract at 0.5 mg/mL reduced the release of reactive oxygen species (ROS) and reactive nitrogen species (RNS) by 44% and 22%, respectively, while increasing the activities of antioxidant enzymes such as SOD by 18% and CAT by 55% [28].Both WEW and AEW exhibited lipid-lowering effects, with similar efficacy observed between the two. These findings are consistent with previous studies on alcohol extracts of Allium chinense [29], water extracts of different concentrations of Ganoderma lucidum tea [30] and alcohol extracts of different doses of Panax notoginseng [31] demonstrating lipidlowering effects.…”

Section: Discussionmentioning

confidence: 97%

Research on the Drying Process and Nutritional and Functional Activities of Walnut Meal Powder with High Added Value

Zhong,

Rong

2024

IJAFSR

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The optimal drying process for walnut meal was determined, and the antioxidant and lipid-lowering functions of walnut meal powder extracts were evaluated to achieve high-value utilization of walnut meal. Walnut meal after desalination was dried using low-temperature hot air drying, microwave drying, and vacuum freeze drying, followed by sieving through a 60-mesh sieve. The vacuum freeze drying process was identified as the optimal drying method based on the determination of polyphenol, flavonoid, polysaccharide, and protein contents, with polyphenol content at 22.88 mg/g, flavonoid content at 0.71 mg/g, polysaccharide content at 16.37 mg/g, and protein content at 91.7 mg/g. Using this as the raw material, the antibacterial circles of the water and alcohol extracts of walnut meal powder against Escherichia coli OP50 were determined. The effects of water and alcohol extracts of walnut meal powder at concentrations of 1.25 mg/mL, 2.5 mg/mL, and 5 mg/mL on the malondialdehyde (MDA) content, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-PX) activity, catalase (CAT) activity, triglyceride (TG) content, oil red O staining, and optical density of Caenorhabditis elegans (C. elegans) were evaluated to assess their antioxidant capacity and lipid-lowering effects. The results showed that within the concentration range of 1.25 mg/mL to 5 mg/mL, both the water and alcohol extracts of walnut meal powder could increase the activities of SOD, CAT, and GSH-PX in C. elegans, reduce the content of the oxidative product MDA (P<0.05), and decrease the TG content in C. elegans, thereby reducing fat deposition. Moreover, the antioxidant capacity and lipid-lowering effects increased with increasing dosage, with the alcohol extract of walnut meal powder exhibiting higher activity than the water extract.

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Medicine and food homology substances: A review of bioactive ingredients, pharmacological effects and applications

Wang,

Zhu,

Liu

et al. 2025

Food Chemistry

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Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans

Cited by 5 publications

References 47 publications

In vitro Evaluation of Skin Related Enzyme Inhibitory Effect and Emulgel Formulation Development Studies of Onobrychis Argyrea subsp. Argyrea with Phytochemical Analysis

In vitro Evaluation of Skin Related Enzyme Inhibitory Effect and Emulgel Formulation Development Studies of Onobrychis Argyrea subsp. Argyrea with Phytochemical Analysis

Research on the Drying Process and Nutritional and Functional Activities of Walnut Meal Powder with High Added Value

Medicine and food homology substances: A review of bioactive ingredients, pharmacological effects and applications

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