Antiadipogenesis and Osseointegration of Strontium-Doped Implant Surfaces

Zhou, Chuan; Chen, Y Q; Zhu, Yang; Lin, Guan; Zhang, L F; Liu, X C; He, Fuming

doi:10.1177/0022034519850574

Cited by 30 publications

(26 citation statements)

References 40 publications

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“…Liu et al indicated that micro/nano strontium-loaded surface implants enhance bone–implant osseointegration in vivo ( Liu et al, 2019a ). In addition, Sr possesses anti-adipogenesis capability and is expected to be applied in dental implantation in the aged population for rapid osseointegration ( Zhou et al, 2019 ). In our study, Sr improves the angiogenic potential of ECs and regulates the osteogenesis by promoting the angiogenic factor VEGFA secreted by ECs and BMSCs.…”

Section: Resultsmentioning

confidence: 99%

Trace Element-Augmented Titanium Implant With Targeted Angiogenesis and Enhanced Osseointegration in Osteoporotic Rats

Yan

et al. 2022

Front. Chem.

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Deteriorated bone quality in osteoporosis challenges the success of implants, which are in urgent need for better early osseointegration as well as antibacterial property for long-term stability. As osteoporotic bone formation tangles with angiogenic clues, the relationship between osteogenesis and angiogenesis has been a novel therapy target for osteoporosis. However, few designs of implant coatings take the compromised osteoporotic angiogenic microenvironment into consideration. Here, we investigated the angiogenic effects of bioactive strontium ions of different doses in HUVECs only and in a co-culture system with BMSCs. A proper dose of strontium ions (0.2–1 mM) could enhance the secretion of VEGFA and Ang-1 in HUVECs as well as in the co-culture system with BMSCs, exhibiting potential to create an angiogenic microenvironment in the early stage that would be beneficial to osteogenesis. Based on the dose screening, we fabricated a bioactive titanium surface doped with zinc and different doses of strontium by plasma electrolytic oxidation (PEO), for the establishment of a microenvironment favoring osseointegration for osteoporosis. The dual bioactive elements augmented titanium surfaces induced robust osteogenic differentiation, and enhanced antimicrobial properties. Augmented titanium implant surfaces exhibited improved bone formation and bone–implant contact under comprehensive assessment of an in vivo bone–implant interface. In conclusion, zinc- and strontium-augmented titanium surface benefits the osseointegration in osteoporosis via promoting osteogenic differentiation, exerting antibacterial efficacy, and stimulating early angiogenesis.

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Section: Resultsmentioning

confidence: 99%

Trace Element-Augmented Titanium Implant With Targeted Angiogenesis and Enhanced Osseointegration in Osteoporotic Rats

Yan

et al. 2022

Front. Chem.

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“…However, the relevant molecular mechanisms have not been fully understood, particularly during osteoporosis. Recently, Zhou et al discovered that the Sr-doped titanium samples could significantly promote osteogenesis by decreasing ROS expression, inhibiting adipogenic differentiation of mesenchymal stem cells in aging rats [ 25 ]. With that said, the exploitation of the anti-oxidative stress mechanism of Sr-doped implants may be the key to realize its anti-osteoporosis potential.…”

Section: Introductionmentioning

confidence: 99%

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

Shen

Fang

Yie

et al. 2022

Bioactive Materials

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The excessive accumulation of reactive oxygen species (ROS) under osteoporosis precipitates a microenvironment with high levels of oxidative stress (OS). This could significantly interfere with the bioactivity of conventional titanium implants, impeding their early osseointegration with bone. We have prepared a series of strontium (Sr)-doped titanium implants via micro-arc oxidation (MAO) to verify their efficacy and differences in osteoinduction capabilities under normal and osteoporotic (high OS levels) conditions. Apart from the chemical composition, all groups exhibited similar physicochemical properties (morphology, roughness, crystal structure, and wettability). Among the groups, the low Sr group (Sr25%) was more conducive to osteogenesis under normal conditions. In contrast, by increasing the catalase (CAT)/superoxide dismutase (SOD) activity and decreasing ROS levels, the high Sr-doped samples (Sr75% and Sr100%) were superior to Sr25% in inducing osteogenic differentiation of MC3T3-E1 cells and the M2 phenotype polarization of RAW264.7 cells, thus enhancing early osseointegration. Furthermore, the results of both in vitro cell co-culture and in vivo studies also showed that the high Sr-doped samples (especially Sr100%) had positive effects on osteoimmunomodulation under the OS microenvironment. Ultimately, the collated findings indicated that the high proportion Sr-doped MAO coatings were more favorable for osteoporosis patients in implant restorations.

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“…Strontium ranelate, an old antiosporotic drug, remains of great interest in bone healing, dentistry and several biological applications . Despite its low toxicity, the drug was discontinued by the producer after the European Medicines Agency reported a slight increase (from 1.1 to 1.7% ) in cardiovascular events involving 7000 tested patients who used placebo or strontium ranelate, respectively.…”

Section: Introductionmentioning

confidence: 99%

On the Amazing Reactivity of the Ranelate Ion: New Applications of an Old Antiosporotic Drug

Rocha¹,

Sihn²,

Uchiyama³

et al. 2019

ChemistrySelect

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Ranelate ion, the major component of an old antiosporotic drug, exhibits a unusual chemical structure encompassing a thiophene ring with two carboxylic groups, a cyanonitrile substituent, and a nitrile diacetate group; it undergoes decarboxylation at the thiophene carbon‐5 position in acidic solutions, yielding a photoreactive (H5Ran) species which converts into a remarkably stable blue dithiophene dye in the presence of UV light and air.

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Antiadipogenesis and Osseointegration of Strontium-Doped Implant Surfaces

Cited by 30 publications

References 40 publications

Trace Element-Augmented Titanium Implant With Targeted Angiogenesis and Enhanced Osseointegration in Osteoporotic Rats

Trace Element-Augmented Titanium Implant With Targeted Angiogenesis and Enhanced Osseointegration in Osteoporotic Rats

High proportion strontium-doped micro-arc oxidation coatings enhance early osseointegration of titanium in osteoporosis by anti-oxidative stress pathway

On the Amazing Reactivity of the Ranelate Ion: New Applications of an Old Antiosporotic Drug

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