Antiadhesin Peptide-Based Vaccines for Pseudomonas aeruginosa

Hartsock, Wendy J.; Hackbarth, Clifton; Hodges, Robert S.

doi:10.1016/b978-0-12-385095-9.00077-4

“…Hodges and coworkers demonstrated that a peptide-based, but not the protein derived, vaccine was able to stimulate a high antibody titer against a native receptor-binding domain of pilin protein from Pseudomonas aeruginosa . 19 Vaccine design based on prediction of the secondary structure of peptide antigen may fail to achieve desired efficacy by the forcing of peptide to adopt the wrong conformation, especially when the secondary structure of the protein antigen is not fully confirmed.…”

Section: Epitope Designmentioning

confidence: 99%

Peptide-based synthetic vaccines

Skwarczynski

¹

,

Tóth

²

2016

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Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

Bui

¹

,

Auroy

²

,

Haupt

³

2022

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Infections caused by antibiotic‐resistant bacteria are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. We highlight how one unique material, molecularly imprinted polymers (MIPs), can orchestrate several strategies to fight this serious societal issue. MIPs are tailor‐made biomimetic supramolecular receptors that recognize and bind target molecules with high affinity and selectivity, comparable to those of antibodies. While research on MIPs for combatting cancer has flourished, comprehensive work on their involvement in combatting resistant superbugs has been rather scarce. This review aims at filling this gap. We will describe the causes of bacterial resistance and at which level MIPs can deploy their weapons. MIPs’ targets can be biofilm constituents, quorum sensing messengers, bacterial surface proteins and antibiotic‐deactivating enzymes, among others. We will conclude with the current challenges and future developments in this field.

show abstract

Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

Bui

¹

,

Auroy

²

,

Haupt

³

2022

View full text Add to dashboard Cite

Infections caused by antibiotic‐resistant bacteria are difficult and sometimes impossible to treat, making them one of the major public health problems of our time. We highlight how one unique material, molecularly imprinted polymers (MIPs), can orchestrate several strategies to fight this serious societal issue. MIPs are tailor‐made biomimetic supramolecular receptors that recognize and bind target molecules with high affinity and selectivity, comparable to those of antibodies. While research on MIPs for combatting cancer has flourished, comprehensive work on their involvement in combatting resistant superbugs has been rather scarce. This review aims at filling this gap. We will describe the causes of bacterial resistance and at which level MIPs can deploy their weapons. MIPs’ targets can be biofilm constituents, quorum sensing messengers, bacterial surface proteins and antibiotic‐deactivating enzymes, among others. We will conclude with the current challenges and future developments in this field.

show abstract

Antiadhesin Peptide-Based Vaccines for Pseudomonas aeruginosa

Cited by 3 publications

References 34 publications

Peptide-based synthetic vaccines

Peptide-based synthetic vaccines

Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

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