Antiabruption dynamics of the intervillous circulation in an artificial uterus

Groeber, Walter R.

doi:10.1016/s0002-9378(16)34739-1

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The increased prevalence of intraplacental hemorrhage in the baboons suggests the possibility that changes in IVS blood flow could contribute to abruption in these species. In a model of artificial placenta, Groeber described IVS blood flow as an essential component of “anti-abruptio forces” (40). IVS blood flow is diminished in human pregnancies complicated by preeclampsia (41) and intrauterine growth restriction (IUGR) (42).…”

Section: Discussionmentioning

confidence: 99%

Abruptio placentae in the baboon (Papio spp.)

Schenone

Schlabritz‐Loutsevitch

Zhang

et al. 2012

Placenta

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Introduction Placental abruption is a serious condition that increases perinatal morbidity and mortality. Clinical prevention and treatment options are limited, especially in human preterm deliveries. Knowledge of the mechanisms that keep the placenta in place during pregnancy is critical for developing strategies for the prevention of abruption. Failure of physiological transformation of spiral arteries has been described as a major contributing factor of the placental abruption development. Baboons (Papio spp.) share striking similarities with humans in regard to placental structure, utero-placental blood flow, and fetal development; however, the mode of trophoblast invasion is shallow in baboons. This fact prompted the hypothesis that the incidence of placental abruption will be increased in baboons compared to humans. Material and methods Baboon placentas were collected between 2002 and 2008. Two independent veterinary pathologists evaluated the slides. A certified physician pathologist performed additional histology. Results Placental abruption was diagnosed in 22 baboons among 2,423 live births during the study period (0.9% prevalence). The most common clinical presentations were fetal demise and vaginal bleeding. The most common pathological findings were intraplacental hemorrhage with or without hematoma formation (86.4%). Other findings consisted of neutrophil infiltration (50%), decidual necrosis (22.7%), decidual vascular congestion and inflammation, villous congestion and retroplacental hemorrhage/hematoma (18.2%). These pathologic findings were the same for term and preterm deliveries. Conclusion This is the first systematic study of placental abruption in non-human primates, analyzing a large colony of baboons. Despite differences in trophoblast invasion, the clinical features observed in placental abruption affecting baboons resembled those reported in humans. The cluster of placental pathological findings in baboons also agreed with clinical reports, but the prevalence of these findings differed between baboons and humans. We discuss a mechanism of anti-abruption forces that offset shallow trophoblast invasion observed in baboons.

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Section: Discussionmentioning

confidence: 99%

Abruptio placentae in the baboon (Papio spp.)

Schenone

Schlabritz‐Loutsevitch

Zhang

et al. 2012

Placenta

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“…The “anti-abruption forces” [3] are proportional to the flow rate in the intervillous space, which is determined by, among other things, the diameter of spiral arteries and veins [4]. Pathologic venous drainage has been suggested contribute to the risk for abruption [5].…”

Section: Discussionmentioning

confidence: 99%

Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis)

Schlabritz‐Loutsevitch

Hubbard

Zhang

et al. 2013

Placenta

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Introduction Abruptio placentae, defined as premature separation of a normally implanted placenta, is the life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae is the major risk factor for this pregnancy complication in humans. We describe the first case of recurrent abruptio placentae in a M. fascicularis. Material and methods A pregnant M. fascicularis at term gestation was presented with weakness and hypothermia. Cesarean section revealed retroplacental hemorrhage with partial placental separation from the uterus. Results The weight of the female fetus was within the lower birth weight range for these species. The maternal side of placenta contained necrotic tissue, occupying approximately 60% of the maternal surface. The placental implantation bed demonstrated neutrophil infiltration. Perivascular collections of lymphocytes were noticed in the uterine smooth muscle. Conclusion This case report underlines the importance of neutrophil infiltration and uterine venous drainage in the cascade of events leading to abruptio placentae.

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Antiabruption dynamics of the intervillous circulation in an artificial uterus

Cited by 2 publications

References 6 publications

Abruptio placentae in the baboon (Papio spp.)

Abruptio placentae in the baboon (Papio spp.)

Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis)

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